Neuroscience

E3 Ubiquitin Ligase Highwire/Phr1 Phase Separation Mediates Endocytic Control of JNK Signaling in Drosophila Neurons

1. Srikanth Pippadpally
2. Anjali Bisht
3. Saumitra Dey Choudhury
4. Manish Kumar Dwivedi
5. Zeeshan Mushtaq
6. Suneel Reddy-Alla
7. Vimlesh Kumar

• Curated by eLife

  eLife Assessment

  This study provides valuable findings on how the activity of the E3 ubiquitin ligase Highwire (Hiw/Phr1) is regulated and its impact on synaptic growth. The authors propose that impaired endocytosis leads to condensation of Hiw, resulting in increased synaptic growth. They also integrate such a mechanism within the known JNK (c-JUN N-terminal Kinase) and BMP (Bone Morphogenetic Protein) signalling pathways involved in synapse regulation. While the work raises an interesting mechanistic framework, several aspects of the experimental design and methodology are incomplete, and key conclusions, particularly those regarding the liquid-liquid phase separation of the E3 ubiquitin ligase, are not fully supported by the presented data.

Reviewed by eLife

Improved sensory representations as a result of temporal adaptation

1. Amber Marijn Brands
2. Zilan Oz
3. Nikolina Vukšić
4. Paulo Ortiz
5. Iris Isabelle Anna Groen

• Curated by eLife

  eLife Assessment

  This valuable study examined how sensory adaptation supports visual perception in the presence of noise. The authors used a combination of human psychophysics, electroencephalography (EEG), and deep neural networks to show that adaptation to noise can improve perception. The results are solid but are, at present, weakened by a number of concerns, including some related to the experimental design and some regarding the interpretation of the results in terms of particular mechanisms. With these concerns adequately addressed, the study and conclusions would be likely to be of broad interest to the neuroscience community.

Reviewed by eLife

Multi-Scale Anti-Correlated Neural States Dominate Naturalistic Whole-Brain Activity

1. Dora Gözükara
2. Djamari Oetringer
3. Nasir Ahmad
4. Linda Geerligs

• Curated by eLife

  eLife Assessment

  This manuscript presents a novel investigation of organizational principles governing brain activity at both global and local scales during naturalistic viewing paradigms, an important advance for theoretical neuroscience, functional neuroimaging, and neurology. The authors demonstrate that brain activity during naturalistic viewing is dominated by two anti-correlated states that toggle between each other with a third transitional state mediating between them. The evidence supporting this finding is compelling, with the successful replication across three independent datasets (StudyForrest, NarrattenTion, and CamCAN) a particular strength.

Reviewed by eLife

Power Pixels: a turnkey pipeline for processing of Neuropixel recordings

1. Guido T. Meijer
2. Francesco P. Battaglia

Reviewed by Peer Community in Neuroscience