Neuroscience

The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in Drosophila

1. Samuel Matthew Frommeyer
2. Ulrike Gigengack
3. Sandra Rode
4. Matthew Davies
5. Neele Wolterhoff
6. Sebastian Rumpf

Reviewed by Review Commons

AutoMorphoTrack: A modular framework for quantitative analysis of organelle morphology, motility, and interactions at single-cell resolution

1. Armin Bayati
2. Jackson G Schumacher
3. Xiqun Chen

• Curated by eLife

  eLife Assessment

  This work describes a useful computational tool for automated morphometry of dynamic organelles from microscope images. However, the supporting evidence and novelty of the manuscript as presented are incomplete and could be improved. The work will be of interest to microscopists and bioimage analysts who are non-experts but wish to improve quantitative analysis of cellular structures.

Reviewed by eLife

Decoding state specific connectivity during speech production and perception

1. Yasamin Esmaeili
2. Amirhossein Khalilian-Gourtani
3. Orrin Devinsky
4. Werner K Doyle
5. Patricia Dugan
6. Daniel Friedman
7. Adeen Flinker

• Curated by eLife

  eLife Assessment

  This work represents a valuable finding of how single-trial functional connectivity may be used to infer different cognitive states involved in speech perception and production. Although the data and analyses are overall convincing, the theoretical advance and novelty of the finding are less clear. With a clearer idea of the functional significance of the connectivity data, the paper would be of interest to those interested in brain networks and communication.

Reviewed by eLife

E3 Ubiquitin Ligase Highwire/Phr1 Phase Separation Mediates Endocytic Control of JNK Signaling in Drosophila Neurons

1. Srikanth Pippadpally
2. Anjali Bisht
3. Saumitra Dey Choudhury
4. Manish Kumar Dwivedi
5. Zeeshan Mushtaq
6. Suneel Reddy-Alla
7. Vimlesh Kumar

• Curated by eLife

  eLife Assessment

  This study provides valuable findings on how the activity of the E3 ubiquitin ligase Highwire (Hiw/Phr1) is regulated and its impact on synaptic growth. The authors propose that impaired endocytosis leads to condensation of Hiw, resulting in increased synaptic growth. They also integrate such a mechanism within the known JNK (c-JUN N-terminal Kinase) and BMP (Bone Morphogenetic Protein) signalling pathways involved in synapse regulation. While the work raises an interesting mechanistic framework, several aspects of the experimental design and methodology are incomplete, and key conclusions, particularly those regarding the liquid-liquid phase separation of the E3 ubiquitin ligase, are not fully supported by the presented data.

Reviewed by eLife

Improved sensory representations as a result of temporal adaptation

1. Amber Marijn Brands
2. Zilan Oz
3. Nikolina Vukšić
4. Paulo Ortiz
5. Iris Isabelle Anna Groen

• Curated by eLife

  eLife Assessment

  This valuable study examined how sensory adaptation supports visual perception in the presence of noise. The authors used a combination of human psychophysics, electroencephalography (EEG), and deep neural networks to show that adaptation to noise can improve perception. The results are solid but are, at present, weakened by a number of concerns, including some related to the experimental design and some regarding the interpretation of the results in terms of particular mechanisms. With these concerns adequately addressed, the study and conclusions would be likely to be of broad interest to the neuroscience community.

Reviewed by eLife

Multi-Scale Anti-Correlated Neural States Dominate Naturalistic Whole-Brain Activity

1. Dora Gözükara
2. Djamari Oetringer
3. Nasir Ahmad
4. Linda Geerligs

• Curated by eLife

  eLife Assessment

  This manuscript presents a novel investigation of organizational principles governing brain activity at both global and local scales during naturalistic viewing paradigms, an important advance for theoretical neuroscience, functional neuroimaging, and neurology. The authors demonstrate that brain activity during naturalistic viewing is dominated by two anti-correlated states that toggle between each other with a third transitional state mediating between them. The evidence supporting this finding is compelling, with the successful replication across three independent datasets (StudyForrest, NarrattenTion, and CamCAN) a particular strength.

Reviewed by eLife