Neuroscience

Disentangled multi-subject and social behavioral representations through a constrained subspace variational autoencoder (CS-VAE)

1. Daiyao Yi
2. Simon Musall
3. Anne Churchland
4. Nancy Padilla-Coreano
5. Shreya Saxena

• Curated by eLife

  eLife assessment

  This paper is a valuable step in multi-subject behavioral modeling using an extension of the Variational Autoencoder (VAE) framework. Using a novel partition of the latent space and in tandem with a recently proposed regularization scheme, the paper provides a rich set of computational analyses analyzing social behavior data of mice with results that represent the state-of-the-art in this subfield. The strength of evidence is convincing, with the methodology being well documented and the results being reproducible, although some additional quantifications would have been helpful to fully gauge the circumstances where the approach would be most effectively applied.

Reviewed by eLife

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

1. Alessio Vittorio Colombo
2. Rebecca Katie Sadler
3. Gemma Llovera
4. Vikramjeet Singh
5. Stefan Roth
6. Steffanie Heindl
7. Laura Sebastian Monasor
8. Aswin Verhoeven
9. Finn Peters
10. Samira Parhizkar
11. Frits Kamp
12. Mercedes Gomez de Aguero
13. Andrew J MacPherson
14. Edith Winkler
15. Jochen Herms
16. Corinne Benakis
17. Martin Dichgans
18. Harald Steiner
19. Martin Giera
20. Christian Haass
21. Sabina Tahirovic
22. Arthur Liesz

Reviewed by eLife

Plis de passage in the superior temporal sulcus: Morphology and local connectivity

1. C. Bodin
2. A. Pron
3. M. Le Mao
4. J. Régis
5. P. Belin
6. O. Coulon

Reviewed by eLife

Protective anti‐prion antibodies in human immunoglobulin repertoires

1. Assunta Senatore
2. Karl Frontzek
3. Marc Emmenegger
4. Andra Chincisan
5. Marco Losa
6. Regina Reimann
7. Geraldine Horny
8. Jingjing Guo
9. Sylvie Fels
10. Silvia Sorce
11. Caihong Zhu
12. Nathalie George
13. Stefan Ewert
14. Thomas Pietzonka
15. Simone Hornemann
16. Adriano Aguzzi

Reviewed by Review Commons

Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation

1. Mareike A. Gann
2. Bradley R. King
3. Nina Dolfen
4. Menno P. Veldman
5. Kimberly L. Chan
6. Nicolaas A.J. Puts
7. Richard A.E. Edden
8. Marco Davare
9. Stephan P. Swinnen
10. Dante Mantini
11. Edwin M. Robertson
12. Geneviève Albouy

Reviewed by eLife

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

1. Carolyn M. Lorch
2. Nikolas W. Hayes
3. Jessica L. Xia
4. Stefan W. Fleps
5. Hayley E. McMorrow
6. Haley S. Province
7. Joshua A. Frydman
8. Jones G. Parker
9. Lisa R. Beutler

Reviewed by preLights

Dorsal raphe stimulation relays a reward signal to the ventral tegmental area via GluN2C NMDA receptors

1. Giovanni Hernandez
2. Willemieke M. Kouwenhoven
3. Emmanuelle Poirier
4. Karim Lebied
5. Daniel Lévesque
6. Pierre-Paul Rompré

Reviewed by Review Commons

Sex-dependent noradrenergic modulation of premotor cortex during decision-making

1. Ellen M Rodberg
2. Carolina R den Hartog
3. Emma S Dauster
4. Elena M Vazey

• Curated by eLife

  eLife assessment

  Rodberg et al. show systemic β adrenergic antagonism reduces engagement in decision-making, particularly in female rats, and reduces task-related encoding in neural activity. This is a valuable finding that addresses a gap in the field, however, the understanding of the direct contribution of β adrenergic receptors to the observed effects is incomplete. Further, the theoretical grounds, data analyses, and results could be improved in several ways.

Reviewed by eLife

Cerebral chemoarchitecture shares organizational traits with brain structure and function

1. Benjamin Hänisch
2. Justine Y Hansen
3. Boris C Bernhardt
4. Simon B Eickhoff
5. Juergen Dukart
6. Bratislav Misic
7. Sofie Louise Valk

• Curated by eLife

  eLife assessment

  This work provides a valuable structural and functional characterization of the neurotransmitter's spatial distribution heterogeneity in cortical and subcortical regions. The authors report a systematic description and annotation of a new "layer" of brain organization that has been relatively poorly integrated with the wider neuroimaging literature to date. In sum, this paper has the potential to be of great interest to a wide audience in neurosciences.

Reviewed by eLife

Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss

1. Yaoxuan Wang
2. Mengda Jiang
3. Yuting Zhu
4. Lu Xue
5. Wenying Shu
6. Xiang Li
7. Hongsai Chen
8. Yun Li
9. Ying Chen
10. Yongchuan Chai
11. Yu Zhang
12. Yinghua Chu
13. Yang Song
14. Xiaofeng Tao
15. Zhaoyan Wang
16. Hao Wu

• Curated by eLife

  eLife assessment

  This important study used high-resolution brain imaging methods to visualize and index non-invasively auditory and language pathways of young children born with inner ear malformations or cochlear nerve dysfunction resulting in profound hearing loss. Nerve fiber impairments were compellingly demonstrated in subcortical auditory and cortical language pathways relative to typically-hearing controls. The results suggested novel approaches for clinical assessment of central auditory and language pathways that may influence different intervention strategies, pending further evidence linking these structural findings with functional outcomes.

Reviewed by eLife