Neuroscience

Specific Neuroligin3–αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus

1. Motokazu Uchigashima
2. Kohtarou Konno
3. Emily Demchak
4. Amy Cheung
5. Takuya Watanabe
6. David G Keener
7. Manabu Abe
8. Timmy Le
9. Kenji Sakimura
10. Toshikuni Sasaoka
11. Takeshi Uemura
12. Yuka Imamura Kawasawa
13. Masahiko Watanabe
14. Kensuke Futai

Reviewed by eLife

Sleep is bi-directionally modified by amyloid beta oligomers

1. Güliz Gürel Özcan
2. Sumi Lim
3. Patricia LA Leighton
4. W Ted Allison
5. Jason Rihel

Reviewed by eLife

Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

1. Damien Lemoine
2. Sarah Mondoloni
3. Jérome Tange
4. Bertrand Lambolez
5. Philippe Faure
6. Antoine Taly
7. Ludovic Tricoire
8. Alexandre Mourot

Reviewed by eLife

Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics

1. Kyle P Blum
2. Kenneth S Campbell
3. Brian C Horslen
4. Paul Nardelli
5. Stephen N Housley
6. Timothy C Cope
7. Lena H Ting

Reviewed by eLife

Reproducible functional connectivity endophenotype confers high risk of ASD diagnosis in a subset of individuals

1. Sebastian GW. Urchs
2. Hien Duy Nguyen
3. Clara Moreau
4. Christian Dansereau
5. Angela Tam
6. Alan C. Evans
7. Pierre Bellec

Reviewed by eLife

History biases reveal novel dissociations between perceptual and metacognitive decision-making

1. Christopher S.Y. Benwell
2. Rachael Beyer
3. Francis Wallington
4. Robin A. A. Ince

Reviewed by eLife

Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

1. Qin Wang
2. Huaxun Fan
3. Feng Li
4. Savanna S Skeeters
5. Vishnu V Krishnamurthy
6. Yuanquan Song
7. Kai Zhang

Reviewed by eLife

Largely distinct networks mediate perceptually-relevant auditory and visual speech representations

1. Anne Keitel
2. Joachim Gross
3. Christoph Kayser

Reviewed by eLife

Disentangled multi-subject and social behavioral representations through a constrained subspace variational autoencoder (CS-VAE)

1. Daiyao Yi
2. Simon Musall
3. Anne Churchland
4. Nancy Padilla-Coreano
5. Shreya Saxena

• Curated by eLife

  eLife assessment

  This paper is a valuable step in multi-subject behavioral modeling using an extension of the Variational Autoencoder (VAE) framework. Using a novel partition of the latent space and in tandem with a recently proposed regularization scheme, the paper provides a rich set of computational analyses analyzing social behavior data of mice with results that represent the state-of-the-art in this subfield. The strength of evidence is convincing, with the methodology being well documented and the results being reproducible, although some additional quantifications would have been helpful to fully gauge the circumstances where the approach would be most effectively applied.

Reviewed by eLife

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

1. Alessio Vittorio Colombo
2. Rebecca Katie Sadler
3. Gemma Llovera
4. Vikramjeet Singh
5. Stefan Roth
6. Steffanie Heindl
7. Laura Sebastian Monasor
8. Aswin Verhoeven
9. Finn Peters
10. Samira Parhizkar
11. Frits Kamp
12. Mercedes Gomez de Aguero
13. Andrew J MacPherson
14. Edith Winkler
15. Jochen Herms
16. Corinne Benakis
17. Martin Dichgans
18. Harald Steiner
19. Martin Giera
20. Christian Haass
21. Sabina Tahirovic
22. Arthur Liesz

Reviewed by eLife