Neuroscience

Protective anti-prion antibodies in human immunoglobulin repertoires

1. Assunta Senatore
2. Karl Frontzek
3. Marc Emmenegger
4. Andra Chincisan
5. Marco Losa
6. Regina Reimann
7. Geraldine Horny
8. Jingjing Guo
9. Sylvie Fels
10. Silvia Sorce
11. Caihong Zhu
12. Nathalie George
13. Stefan Ewert
14. Thomas Pietzonka
15. Simone Hornemann
16. Adriano Aguzzi

Reviewed by Review Commons

Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation

1. Mareike A. Gann
2. Bradley R. King
3. Nina Dolfen
4. Menno P. Veldman
5. Kimberly L. Chan
6. Nicolaas A. J. Puts
7. Richard A. E. Edden
8. Marco Davare
9. Stephan P. Swinnen
10. Dante Mantini
11. Edwin M. Robertson
12. Geneviève Albouy

Reviewed by eLife

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

1. Carolyn M. Lorch
2. Nikolas W. Hayes
3. Jessica L. Xia
4. Stefan W. Fleps
5. Hayley E. McMorrow
6. Haley S. Province
7. Joshua A. Frydman
8. Jones G. Parker
9. Lisa R. Beutler

Reviewed by preLights

Dorsal raphe stimulation relays a reward signal to the ventral tegmental area via GluN2C NMDA receptors

1. Giovanni Hernandez
2. Willemieke M Kouwenhoven
3. Poirier Emmanuelle
4. Lebied Karim
5. Daniel Lévesque
6. Pierre-Paul Rompré

Reviewed by Review Commons

Sex-dependent noradrenergic modulation of premotor cortex during decision-making

1. Ellen M Rodberg
2. Carolina R den Hartog
3. Emma S Dauster
4. Elena M Vazey

• Curated by eLife

  eLife assessment

  Rodberg et al. show systemic β adrenergic antagonism reduces engagement in decision-making, particularly in female rats, and reduces task-related encoding in neural activity. This is a valuable finding that addresses a gap in the field, however, the understanding of the direct contribution of β adrenergic receptors to the observed effects is incomplete. Further, the theoretical grounds, data analyses, and results could be improved in several ways.

Reviewed by eLife

Cerebral chemoarchitecture shares organizational traits with brain structure and function

1. Benjamin Hänisch
2. Justine Y Hansen
3. Boris C Bernhardt
4. Simon B Eickhoff
5. Juergen Dukart
6. Bratislav Misic
7. Sofie Louise Valk

• Curated by eLife

  eLife assessment

  This work provides a valuable structural and functional characterization of the neurotransmitter's spatial distribution heterogeneity in cortical and subcortical regions. The authors report a systematic description and annotation of a new "layer" of brain organization that has been relatively poorly integrated with the wider neuroimaging literature to date. In sum, this paper has the potential to be of great interest to a wide audience in neurosciences.

Reviewed by eLife

Impact of inner ear malformation and cochlear nerve deficiency on the development of auditory-language network in children with profound sensorineural hearing loss

1. Yaoxuan Wang
2. Mengda Jiang
3. Yuting Zhu
4. Lu Xue
5. Wenying Shu
6. Xiang Li
7. Hongsai Chen
8. Yun Li
9. Ying Chen
10. Yongchuan Chai
11. Yu Zhang
12. Yinghua Chu
13. Yang Song
14. Xiaofeng Tao
15. Zhaoyan Wang
16. Hao Wu

• Curated by eLife

  eLife assessment

  This important study used high-resolution brain imaging methods to visualize and index non-invasively auditory and language pathways of young children born with inner ear malformations or cochlear nerve dysfunction resulting in profound hearing loss. Nerve fiber impairments were compellingly demonstrated in subcortical auditory and cortical language pathways relative to typically-hearing controls. The results suggested novel approaches for clinical assessment of central auditory and language pathways that may influence different intervention strategies, pending further evidence linking these structural findings with functional outcomes.

Reviewed by eLife

Functional imaging of conduction dynamics in cortical and spinal axons

1. Milos Radivojevic
2. Anna Rostedt Punga

• Curated by eLife

  eLife assessment

  This work provides fundamental new insight into fine axonal morphologies based solely on extracellular action potential recordings. They provide compelling evidence of fine resolution in mapping functional connections between neurons. The work may have broad use in neurobiology, bioengineering, stem cell biology, as well as tissue engineering in functional characterization.

Reviewed by eLife

A transposase-derived gene required for human brain development

1. Luz Jubierre Zapater
2. Sara A. Lewis
3. Rodrigo Lopez Gutierrez
4. Makiko Yamada
5. Elias Rodriguez-Fos
6. Merce Planas-Felix
7. Daniel Cameron
8. Phillip Demarest
9. Anika Nabila
10. Helen Mueller
11. Junfei Zhao
12. Paul Bergin
13. Casie Reed
14. Tzippora Chwat-Edelstein
15. Alex Pagnozzi
16. Caroline Nava
17. Emilie Bourel-Ponchel
18. Patricia Cornejo
19. Ali Dursun
20. R. Köksal Özgül
21. Halil Tuna Akar
22. Reza Maroofian
23. Henry Houlden
24. Huma Arshad Cheema
25. Muhammad Nadeem Anjum
26. Giovanni Zifarelli
27. Miriam Essid
28. Meriem Ben Hafsa
29. Hanene Benrhouma
30. Carolina Isabel Galaz Montoya
31. Alex Proekt
32. Xiaolan Zhao
33. Nicholas D. Socci
34. Matthew Hayes
35. Yves Bigot
36. Raul Rabadan
37. David Torrents
38. Claudia L Kleinmann
39. Michael C. Kruer
40. Miklos Toth
41. Alex Kentsis

Reviewed by preLights

Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways

1. Aakanksha Jain
2. Benjamin M. Gyori
3. Sara Hakim
4. Samuel Bunga
5. Daniel G Taub
6. Mari Carmen Ruiz-Cantero
7. Candace Tong-Li
8. Nicholas Andrews
9. Peter K Sorger
10. Clifford J Woolf

Reviewed by preLights