1. Learning place cells and remapping by decoding the cognitive map

    This article has 4 authors:
    1. Markus Borud Pettersen
    2. Vemund Schøyen
    3. Anders Malthe-Sørenssen
    4. Mikkel E Lepperød
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful modeling study shows how spatial representations similar to experiment emerge in a recurrent neural network trained on a navigation task by requiring path integration and decodability, but without relying on grid cells. The network modeling results are solid, although the link to experimental data may benefit from further development.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  2. Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

    This article has 5 authors:
    1. Hans Kirschner
    2. Hanna M Molla
    3. Matthew R Nassar
    4. Harriet de Wit
    5. Markus Ullsperger
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript reports effects of a single dose of methamphetamine vs placebo on a probabilistic reversal learning task with different levels of noise, in a large group of young healthy volunteers. The paper is well written and the methods are rigorous. The findings are important and have theoretical or practical implications beyond a single a subfield. The strength of the evidence is convincing, with the methods, data, and analyses broadly supporting the claims in the paper, which are sufficiently qualified given the lack of a significant effect of the binary baseline performance variable, and the nonlinear effect of individual differences in baseline performance.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques

    This article has 7 authors:
    1. Amber M Howell
    2. Shaun Warrington
    3. Clara Fonteneau
    4. Youngsun T Cho
    5. Stamatios N Sotiropoulos
    6. John D Murray
    7. Alan Anticevic
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study describes patterns of anatomical connectivity between the cortex and the thalamus using magnetic resonance imaging data in humans and non-human primates. The measures are related to numerous other modalities to develop a robust understanding of the organisation of the system. The authors provide convincing evidence that there is a difference between sensory and association cortices in terms of their connectivity with the thalamus, which may have downstream effects on brain function. This work will be of interest to neuroscientists interested in the organization and dynamics of cortico-thalamic circuits.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea

    This article has 6 authors:
    1. Peter J Murphy
    2. Juliette E McGregor
    3. Zhengyang Xu
    4. Qiang Yang
    5. William Merigan
    6. David R Williams
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper shows that it is possible to optogenetically activate single retinal ganglion cells in vivo in monkeys. This is an important step towards towards causal tests of the role of specific ganglion cell types in visual perception. The paper presents convincing evidence for the promise of the approach but further work will be needed to full explore its limitations and specificity.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Inhibitory circuits generate rhythms for leg movements during Drosophila grooming

    This article has 3 authors:
    1. Durafshan Sakeena Syed
    2. Primoz Ravbar
    3. Julie H Simpson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Using a combination of connectomics, optogenetics, behavioral analysis, and modeling, this study provides important findings on the role of two populations of inhibitory neurons in the generation of leg grooming movements in Drosophila. The data as presented provide incomplete evidence that the identified neuronal populations contribute to the alternation of flexion and extension by inhibiting specific sets of motor neurons while disinhibiting their counterparts. While the manuscript provides comprehensive details about the 13A/B neuronal populations involved in grooming control, updates on statistics, and explicit mentioning of experimental/modeling caveats would strengthen the study. The work will interest neuroscientists, and particularly those working on motor control.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

    This article has 5 authors:
    1. Javier Emperador-Melero
    2. Steven J Del Signore
    3. Kevin M De León González
    4. Pascal S Kaeser
    5. Avital A Rodal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila and rodent model systems, to define the role of activity and active zone structure on the organization of the peri-active zone. While the findings are primarily negative, they are carefully executed and contribute to the field by refining existing models of presynaptic organization.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Dynamic fMRI networks of emotion

    This article has 4 authors:
    1. Niels Janssen
    2. Uriel KA Elvira
    3. Joost Janssen
    4. Theo GM van Erp
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable information on the neurodynamics of emotional processing while participants were watching movie clips. The methods and results were solid in deciphering the temporal-spatial dynamics of emotional processing. This work will be of interest to affective neuroscientists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Gamma Synchrony Mediates Figure-Ground Perception

    This article has 4 authors:
    1. Maryam Karimian
    2. Mark J Roberts
    3. Peter De Weerd
    4. Mario Senden
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Karimian et al. present a valuable new model to explain how gamma-band synchrony (30-80 Hz) can support human visual feature binding by selectively grouping image elements, countering recent criticisms that the stimulus dependence of gamma oscillations limits their functional role. Grounded in the theory of weakly coupled oscillators and informed by primate electrophysiology, the model captures behavioural patterns observed in human psychophysics, offering support for the potential role of synchrony-based mechanisms, but incomplete evidence for a specific role of gamma oscillations. This work could be strengthened by more direct evidence for the proposed mechanism, and expanding beyond figure-only model inputs with limited ecological validity.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. A temporally restricted function of the dopamine receptor Dop1R2 during memory formation

    This article has 6 authors:
    1. Jenifer C Kaldun
    2. Emanuele Calia
    3. Ganesh Chinmai Bangalore Mukunda
    4. Cornelia Fritsch
    5. Nikita Komarov
    6. Simon G Sprecher
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors design and implement an elegant strategy to delete genomic sequences encoding the dopamine receptor dop1R2 from specific subsets of mushroom body neurons (ab, a'b' and gamma) and show that while none of these manipulations affect short term appetitive or aversive memory, loss of dop1R2 from ab or a'b' block the ability of flies to display measurable forms of longer forms of memory. These findings are important in confirming and extending prior observations, and well supported by convincing evidence that build on precise techniques for genetic perturbation.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects: results from a pharmacological fMRI study

    This article has 3 authors:
    1. Janne Ina Nold
    2. Tahmine Fadai
    3. Christian Büchel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, Nold et al. examined exercise-induced pain modulation in a pharmacological within-subject fMRI study using the opioid-antagonist naloxone and different levels of aerobic exercise intensity and pain. This investigation provides solid evidence to show that the intensity of exercise does not seem to impact the hypoalgesic effect. Moreover, exploratory analysis identified that fitness level and sex may potentially play a role in exercise-induced hypoalgesia, and that further confirmatory studies are required in order to verify these findings.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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