1. Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances

    This article has 3 authors:
    1. Zachary Fournier
    2. Leandro M Alonso
    3. Eve Marder
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides compelling insights into the differential impact of intrinsic and synaptic conductances on circuit robustness using computational models of the pyloric network from the crustacean stomatogastric ganglion. The results demonstrate that model networks are more sensitive to perturbations in intrinsic conductances than in synaptic conductances, highlighting the critical role of intrinsic plasticity in stabilizing neuronal networks. These findings underscore the importance of intrinsic plasticity, a crucial yet often overlooked factor in neuronal dynamics. The generality of these conclusions should be tested across diverse networks and functions.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex

    This article has 10 authors:
    1. Eun Hye Park
    2. Kally C O'Reilly Sparks
    3. Griffin Grubbs
    4. David Taborga
    5. Kyndall Nicholas
    6. Armaan S Ahmed
    7. Natalie Ruiz-Péreza
    8. Natalie Kim
    9. Simon Segura-Carrillo
    10. André A Fenton
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study includes convincing evidence to show that behavioral measures and hippocampal representations when animals use task-relevant information and ignore irrelevant information do not depend on the medial prefrontal cortex. The results are expected to be of interest to those studying neural mechanisms of cognitive control and functions of associational brain regions.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

    This article has 4 authors:
    1. J Daniel Obray
    2. Erik T Wilkes
    3. Mike Scofield
    4. L Judson Chandler
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript presents important information as to how adolescent alcohol exposure (AIE) alters pain behavior and relevant neurocircuits, with convincing data. The manuscript focuses on how AIE alters the basolateral amygdala, to the PFC (PV-interneurons), to the periaquaductal gray circuit, resulting in feed-forward inhibition. The manuscript is a detailed study of the role of alcohol exposure in regulating the circuit and reflexive pain, however, the role of the PV interneurons in mechanistically modulating this feed-forward circuit could be more strongly supported.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. The NIH BRAIN Initiative’s Impacts in Systems and Computational Neuroscience and Team-Scale Research, 2014-2023

    This article has 8 authors:
    1. Farah Bader
    2. Clayton Bingham
    3. Karen K David
    4. Hermon Gebrehiwet
    5. Crystal Lantz
    6. Grace CY Peng
    7. Mauricio Rangel-Gomez
    8. James Gnadt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript presents some useful accounts of experiences funding team projects within the BRAIN Initiative. These would be more appropriate to add to the companion manuscript since the present manuscript contains some overlapping analyses and does not stand well on its own. Therefore the evidence supporting the conclusions is incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Relative Timescale of Channel Voltage-Dependence and Channel Density Regulation Impacts Assembly and Recovery of Activity

    This article has 3 authors:
    1. Yugarshi Mondal
    2. Ronald L. Calabrese
    3. Eve Marder
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important computational study investigates homeostatic plasticity mechanisms that neurons may employ to achieve and maintain stable target activity patterns. The work extends previous analyses of calcium-dependent homeostatic mechanisms based on ion channel density by considering activity-dependent shifts in channel activation and inactivation properties that operate on faster and potentially variable timescales. The model simulations demonstrate the potential functional importance of these mechanisms, but the evidence is incomplete and would be strengthened by more in-depth analyses and explicit exposition.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Longitudinal assessment of DREADD expression and efficacy in the monkey brain

    This article has 14 authors:
    1. Yuji Nagai
    2. Yukiko Hori
    3. Ken-ichi Inoue
    4. Toshiyuki Hirabayashi
    5. Koki Mimura
    6. Kei Oyama
    7. Naohisa Miyakawa
    8. Yuki Hori
    9. Haruhiko Iwaoki
    10. Katsushi Kumata
    11. Ming-Rong Zhang
    12. Masahiko Takada
    13. Makoto Higuchi
    14. Takafumi Minamimoto
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides a novel and critically important insight into the long-term use of DREADDs to modulate neuronal activity in nonhuman primates. The methods are compelling, demonstrating the peak dynamics and the subsequent stability of chemogenetic effects for 1.5 years, informing experimental designs and interpretation of highly impactful chemogenetic studies in macaques. The protocols, data, and outcomes can serve as guidelines for future experiments. Therefore, the findings will be of significant interest to the field of chemogenetics and may also be of broader interest to researchers and clinicians who seek to utilize viral vectors and/or related genetic technologies.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Precision cutaneous stimulation in freely moving mice

    This article has 4 authors:
    1. Isobel Parkes
    2. Ara Schorscher-Petcu
    3. Qinyi Gan
    4. Liam E Browne
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study combines real-time keypoint tracking with transdermal activation of sensory neurons to investigate sensory neuron recruitment in freely moving mice, and builds on the authors' prior work in stationary mice. The evidence supporting the utility of the system is solid, although a more thorough classification of the behavioral responses to nociceptor stimulation would strengthen the work. Importantly, future analyses could include other cutaneous sensory neuron subtypes, and could also be adapted for studying more complex behaviors. The work will be of interest to sensory biologists and pain researchers.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Evolution of taste processing shifts dietary preference

    This article has 6 authors:
    1. Enrico Bertolini
    2. Daniel Münch
    3. Justine Pascual
    4. Noemi Sgammeglia
    5. Carlos Ribeiro
    6. Thomas O. Auer

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Synchronous Ensembles of Hippocampal CA1 Pyramidal Neurons During Novel Exploration

    This article has 4 authors:
    1. En-Li Chen
    2. Tsai-Wen Chen
    3. Eric R. Schreiter
    4. Bei-Jung Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful study, the authors perform voltage imaging of CA1 pyramidal cells in head-fixed mice running on a track while local field potentials (LFPs) are recorded. The authors conclude that synchronous ensembles of neurons are differentially associated with different types of LFP patterns, namely theta and ripples. However, evidence for the claims in the paper remains incomplete, due to caveats of the experimental approach and claims that are based on a relatively sparse data set collected with a cutting-edge but still largely untested method.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  10. Quantification of the effect of hemodynamic occlusion in two-photon imaging of mouse cortex

    This article has 4 authors:
    1. Baba Yogesh
    2. Matthias Heindorf
    3. Rebecca Jordan
    4. Georg B Keller
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study conducted experiments to quantify how neural activity independent changes in fluorescence might affect two-photon recordings when using diverse sensors. The researchers found a widespread presence of neural-activity-independent artifacts in two-photon imaging and provide convincing evidence that these artifacts are most likely caused by hemodynamic occlusion. Their findings underscore the importance of accounting for these artifacts when interpreting functional two-photon recordings.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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