Neuroscience

Drosophila gustatory projections are segregated by taste modality and connectivity

1. Stefanie Engert
2. Gabriella R Sterne
3. Davi D Bock
4. Kristin Scott

• Curated by eLife

  Evaluation Summary:

  The authors reconstructed the axons of gustatory receptor neurons from the labellum in an EM volume of a whole adult Drosophila brain. The authors were able to correlate the EM data with light microscopic data in terms of the identity of neurons reconstructed, thus enabling the use of published functional data already available in terms of different taste modalities. This revealed that extensive synaptic connections are found between neurons of the same modality. This paper will be of interest to neuroscientists working in the field of circuits and behavior, especially feeding behavior.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking

1. Marshall A Dalton
2. Arkiev D'Souza
3. Jinglei Lv
4. Fernando Calamante

• Curated by eLife

  Evaluation Summary:

  The work presented herein presents a novel method to characterize hippocampal-cortical anatomical network connectivity. These important results have the potential to generate new hypotheses and influence future queries into the hippocampal-cortical system.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline

1. Daphne Chylinski
2. Maxime Van Egroo
3. Justinas Narbutas
4. Vincenzo Muto
5. Mohamed Ali Bahri
6. Christian Berthomier
7. Eric Salmon
8. Christine Bastin
9. Christophe Phillips
10. Fabienne Collette
11. Pierre Maquet
12. Julie Carrier
13. Jean-Marc Lina
14. Gilles Vandewalle

• Curated by eLife

  Evaluation Summary

  This paper is of interest to neuroscientists studying sleep, memory, and neurodegeneration. The authors found that an altered pattern of brain wave during NREM sleep, changes in the coupling of spindles and slow waves, correlates with amyloid burden and predicts memory decline over time in healthy older individuals. The results suggest that sleep brain waves may be a useful tool in identifying older adults at risk for future cognitive impairment in the earliest stage.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

1. Robin F Dard
2. Erwan Leprince
3. Julien Denis
4. Shrisha Rao Balappa
5. Dmitrii Suchkov
6. Richard Boyce
7. Catherine Lopez
8. Marie Giorgi-Kurz
9. Tom Szwagier
10. Théo Dumont
11. Hervé Rouault
12. Marat Minlebaev
13. Agnès Baude
14. Rosa Cossart
15. Michel A Picardo

• Curated by eLife

  Evaluation Summary:

  This study investigates hippocampal dynamics over the course of early postnatal development with respect to spontaneous movements. Pioneering in vivo imaging in the hippocampus of neonatal mice, the authors find evidence for an abrupt developmental transition in this neural activity at the end of the first postnatal week in rodents and contribute to the understanding of how cognitive functions could emerge from the immature brain.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Contribution of behavioural variability to representational drift

1. Sadra Sadeh
2. Claudia Clopath

• Curated by eLife

  Evaluation Summary:

  This work builds on rapidly accumulating evidence for the importance of measuring and accounting for behavior in neural data, and will be of interest to a broad neuroscience audience. Analyses of Allen Brain Atlas datasets show that sensory representations change and match up reliably with behavioral state. The manuscript's main conclusions are supported by the data and analyses and the work raises important questions about previous accounts of the sources of representational drift in sensory areas of the brain.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

1. Emeric Merour
2. Hatem Hmidan
3. Corentine Marie
4. Pierre-Henri Helou
5. Haiyang Lu
6. Antoine Potel
7. Jean-Baptiste Hure
8. Adrien Clavairoly
9. Yi Ping Shih
10. Salman Goudarzi
11. Sebastien Dussaud
12. Philippe Ravassard
13. Sassan Hafizi
14. Su Hao Lo
15. Bassem A Hassan
16. Carlos Parras

Reviewed by Review Commons

A generalized cortical activity pattern at internally generated mental context boundaries during unguided narrative recall

1. Hongmi Lee
2. Janice Chen

• Curated by eLife

  Evaluation Summary:

  This manuscript is of interest to cognitive neuroscientists working on topics broadly related to memory, event segmentation and mental context. It presents an interesting set of new analyses related to internally versus externally driven changes in mental context. The idea is innovative and the analyses and methods are thoughtful and rigorous. There are some concerns about the degree to which the interpretations are supported by the data, but they could potentially be resolved with additional control analyses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Quantitative MRI reveals differences in striatal myelin in children with DLD

1. Saloni Krishnan
2. Gabriel J Cler
3. Harriet J Smith
4. Hanna E Willis
5. Salomi S Asaridou
6. Máiréad P Healy
7. Daniel Papp
8. Kate E Watkins

• Curated by eLife

  Evaluation Summary:

  This is a paper that will be of broad interest to cognitive scientists, cognitive neuroscientists and speech pathologists who study language disorders. They apply a new structural neuro-imaging technique - multi-parameter mapping (MPM) to a very large sample of children with and without developmental language disorders. MPM allows them to identify localized structural differences (particularly myelin) that cannot be observed with other techniques. It offers convincing evidence that differences in a range of neural structures--including theoretically motivated left hemisphere language areas, and procedural learning--can be linked to variation in language ability.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Nigrostriatal dopamine signals sequence-specific action-outcome prediction errors

1. Nick G. Hollon
2. Elora W. Williams
3. Christopher D. Howard
4. Hao Li
5. Tavish I. Traut
6. Xin Jin

• Curated by eLife

  Evaluation Summary:

  This manuscript is of interest to neuroscientists conducting reward learning and basal ganglia research. It combines optogenetics and dopamine recordings to demonstrate that dopamine release in the dorsal striatum is smaller following self-stimulation than unpredicted stimulation of dopamine neurons. These results build on similar findings recently shown for the ventral striatum. Further development of the underlying mechanism or the behavioral significance would broaden the scope of the paper.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

1. Daria Lukasz
2. Alisha Beirl
3. Katie Kindt

• Curated by eLife

  Evaluation Summary:

  Hair cell activity has been postulated to underlie their vulnerability to environmental insult including toxin exposure. Previous work has been confounded by the fact that reducing mechanotransduction also reduces entry of toxic chemicals. Here Lukasz and colleagues test these ideas by examining the vulnerability of zebrafish mutants with impaired synaptic activity, thought to be a major driver of neuronal metabolic load.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife