Neuroscience

Spike-phase coupling patterns reveal laminar identity in primate cortex

1. Zachary W Davis
2. Nicholas M Dotson
3. Tom P Franken
4. Lyle Muller
5. John H Reynolds

• Curated by eLife

  eLife assessment

  The authors present a novel and precise method for determining boundaries of cortical layers from multi-electrode recordings in marmosets and macaques. Their method requires less data than current approaches to finding a systematic relationship between slow local field potentials and spiking across cortical columns. This approach may be broadly useful to those doing electrophysiological recordings in the primate brain.

Reviewed by eLife

Contribution of linear and nonlinear mechanisms to predictive motion estimation

1. Belle Liu
2. Arthur Hong
3. Fred Rieke
4. Michael B. Manookin

• Curated by eLife

  eLife assessment

  This paper will be of interest to sensory and computational neuroscientists. In it, the authors find maximally informative dimensions for primate retinal ganglion cells and use models based on these analyses to examine features of early visual processing that impact predictive coding of visual motion.

Reviewed by eLife

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

1. Kieran A Boyle
2. Erika Polgar
3. Maria Gutierrez-Mecinas
4. Allen C Dickie
5. Andrew H Cooper
6. Andrew M Bell
7. Evelline Jumolea
8. Adrian Casas-Benito
9. Masahiko Watanabe
10. David I Hughes
11. Gregory A Weir
12. John S Riddell
13. Andrew J Todd

• Curated by eLife

  eLife assessment

  Boyle et al identify Npy-expressing dorsal horn neurons as powerfully inhibiting pain and itch under normal and pathological conditions. The valuable data are convincing, and the effect sizes are robust and directly challenge previous work.

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Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons

1. Akane Hatsuda
2. Junko Kurisu
3. Kazuto Fujishima
4. Ayano Kawaguchi
5. Nobuhiko Ohno
6. Mineko Kengaku

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Mrj an Hsp40 family chaperone regulates the oligomerization of Orb2 and long-term memory

1. Meghal Desai
2. Hemant
3. Ankita Deo
4. Jagyanseni Naik
5. Tania Bose
6. Amitabha Majumdar

Reviewed by Review Commons

Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

1. Domenica Ippolito
2. Dominique A Glauser

• Curated by eLife

  eLife assessment

  This valuable study provides solid results on the molecular signaling mechanisms of CaM kinase kinase-1 (CKK-1) in the context of the nociceptive behaviors of C. elegans. The authors report previously undescribed elements that control the nuclear/cytoplasmic shuttling of CKK-1, suggesting a complex interplay of multiple nuclear localization and export sequences. Therefore, the work will be of broad interest to scientists studying behavior, neuronal signaling, and signal transduction in general.

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Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

1. Janani Parameswaran
2. Nancy Zhang
3. Elke Braems
4. Kedamawit Tilahun
5. Devesh C Pant
6. Keena Yin
7. Seneshaw Asress
8. Kara Heeren
9. Anwesha Banerjee
10. Emma Davis
11. Samantha L Schwartz
12. Graeme L Conn
13. Gary J Bassell
14. Ludo Van Den Bosch
15. Jie Jiang

• Curated by eLife

  eLife assessment

  The current study provides important, mechanistic insight into the potential contribution of antisense C4G2 expanded RNA to disease in C9orf72-associated ALS/FTD. The authors convincingly demonstrate that expression of this RNA species activates the PKR/eIF2α-dependent integrated stress response. They further provide evidence that this can contribute to disease phenotypes using multiple models and post-mortem patient samples.

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Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

1. Ruben van den Bosch
2. Frank H Hezemans
3. Jessica I Määttä
4. Lieke Hofmans
5. Danae Papadopetraki
6. Robbert-Jan Verkes
7. Andre F Marquand
8. Jan Booij
9. Roshan Cools

• Curated by eLife

  eLife assessment

  This fundamental work shows the absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity. The evidence supporting the conclusions is compelling, with rigorous PET investigations and state-of-the-art cognitive assessments in a large sample. Given the high interest in the role of dopamine, the work will be of very broad interest to basic neuroscientists, clinical neuroscientists, and clinicians including neurologists and psychiatrists.

Reviewed by eLife

Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors

1. Claudia Dell'Amico
2. Marilyn M Angulo Salavarria
3. Yutaka Takeo
4. Ichiko Saotome
5. Maria Teresa Dell'Anno
6. Maura Galimberti
7. Enrica Pellegrino
8. Elena Cattaneo
9. Angeliki Louvi
10. Marco Onorati

• Curated by eLife

  eLife assessment

  The paper is of interest to neuroscientists, developmental biologists, and those interested in mechanisms that underlie intellectual disability. The study is well executed and brings new insight into the role of WDR62 and its role in causing microcephaly. The key claims of the manuscript require additional data.

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Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish

1. Sol Pose-Méndez
2. Paul Schramm
3. Barbara Winter
4. Jochen C Meier
5. Konstantinos Ampatzis
6. Reinhard W Köster

• Curated by eLife

  eLife assessment

  The present manuscript addresses the controversial issue of the regeneration potential of cerebellar Purkinje cells in zebrafish and their integration into functional circuits. The authors use interesting genetic models to induce Purkinje cell-specific ablation to demonstrate regeneration of Purkinje cells can occur until adulthood and is accomplished by ptf1a+ progenitors. They further show that regenerated neurons reestablish electrophysiological properties and support appropriate behavior. These are important results that may help understand why mammalian neurons do not have similar properties and fail to regenerate. The conclusions on the source of regenerated neurons will however need additional experimental support.

Reviewed by eLife