Neuroscience

Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication

1. Catherine Perrodin
2. Colombine Verzat
3. Daniel Bendor

• Curated by eLife

  eLife assessment

  This valuable work advances our understanding of the acoustic features driving the attraction of female mice to male vocalizations. The evidence supporting the conclusions is solid, with well-designed place preference assays and manipulations of male song structure. The work will be of broad interest to neurobiologists and ethologists working on mouse social interactions, auditory processing and communication.

Reviewed by eLife

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

1. Surya Chandra Rao Thumu
2. Monika Jain
3. Sumitha Soman
4. Soumen Das
5. Vijaya Verma
6. Arnab Nandi
7. David H Gutmann
8. Balaji Jayaprakash
9. Deepak Nair
10. James P Clement
11. Swananda Marathe
12. Narendrakumar Ramanan

Reviewed by Review Commons

Bidirectional chemogenetic modulation of claustral activity causes altered cortical dynamics

1. Ryan Zahacy
2. Yonglie Ma
3. Ian R. Winship
4. Jesse Jackson
5. Allen W. Chan

Reviewed by Arcadia Science

Behavioral entrainment to rhythmic auditory stimulation can be modulated by tACS depending on the electrical stimulation field properties

1. Yuranny Cabral-Calderin
2. Daniela van Hinsberg
3. Axel Thielscher
4. Molly J Henry

• Curated by eLife

  eLife assessment

  This detailed and well powered manuscript explores auditory perception of modulated noise in the presence of transcranial alternating-current stimulation (tACS) and shows valuable results suggesting that there are subject-specific effects when the phase of 2-Hz tACS varies relative to the phase of the noise modulation. The strength of the evidence is mixed. There is convincing evidence that tACS alters perception significantly in individuals; however, the effects are inconsistent across subjects and even across sessions, frustrating attempts to draw conclusions about the underlying mechanisms of the idiosyncratic effects. Despite these limitations, the paper will be of great interest to researchers interested in determining when and how tACS influences neural processes, especially those interested in neural entrainment and its relationship to perception.

Reviewed by eLife

Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs

1. Jiatong Ji
2. Honglu Chao
3. Huimei Chen
4. Jun Liao
5. Wenqian Shi
6. Yangfan Ye
7. Tian Wang
8. Yongping You
9. Ning Liu
10. Jing Ji
11. Enrico Petretto

Reviewed by Review Commons

Characterization of Identified Dopaminergic Neurons in the Mouse Forebrain and Midbrain

1. Maggy Yu Hei Lau
2. Sana Gadiwalla
3. Susan Jones
4. Elisa Galliano

Reviewed by preLights

Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells

1. John A Gaynes
2. Samuel A Budoff
3. Michael J Grybko
4. Alon Poleg-Polsky

• Curated by eLife

  eLife assessment

  This important study uses a combination of computational modeling and glutamate imaging to show how a particular synaptic organization referred to as space-time wiring contributes minimally to a dendritic computation that occurs in the retina. The evidence supporting the claims of the authors is compelling, incorporating new findings regarding dynamic receptive field properties, an improvement over previous modeling and experimental results based on static visual stimuli. The work will be of interest to retinal neurobiologists and neurophysiologists interested in dendritic computations.

Reviewed by eLife

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

1. Lukas M Weber
2. Heena R Divecha
3. Matthew N Tran
4. Sang Ho Kwon
5. Abby Spangler
6. Kelsey D Montgomery
7. Madhavi Tippani
8. Rahul Bharadwaj
9. Joel E Kleinman
10. Stephanie C Page
11. Thomas M Hyde
12. Leonardo Collado-Torres
13. Kristen R Maynard
14. Keri Martinowich
15. Stephanie C Hicks

• Curated by eLife

  eLife assessment

  This is an important initial study of cell type and spatially resolved gene expression in and around the locus coeruleus, the primary source of the neuromodulator norepinephrine in the human brain. The data are generated with cutting-edge techniques, and the work lays the foundation for future descriptive and experimental approaches to understand the contribution of the locus coeruleus to healthy brain function and disease. The empirical support for the main conclusions is solid. This paper, and the associated web application, will be of great interest to neuroscientists working on arousal-based behaviors and neurological and neuropsychiatric phenotypes.

Reviewed by eLife

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

1. Andrew J. Crowther
2. Sakeen W. Kashem
3. Madison E. Jewell
4. Henry Le Chang
5. Mariela Rosa Casillas
6. Élora Midavaine
7. Sian Rodriguez
8. Joao M. Braz
9. Artur Kania
10. Allan I. Basbaum

Reviewed by Arcadia Science

RETRACTED: PAK3 downregulation induces cognitive impairment following cranial irradiation

1. Haksoo Lee
2. Hyunkoo Kang
3. Changjong Moon
4. BuHyun Youn

• Curated by eLife

  eLife assessment

  The study investigates the functional impact of cranial irradiation in mouse and proposes PAK3 as molecular element involved in radiation-induced cognitive decrement. The significance of the findings is useful for fields covering radiation, brain tumor and cognition. The strength of evidence is solid, although the referees expressed divergent views on the manuscript.

Reviewed by eLife