Neuroscience

A stochastic world model on gravity for stability inference

1. Taicheng Huang
2. Jia Liu

• Curated by eLife

  eLife assessment

  In this valuable study, the authors present findings that suggest that people do not faithfully replicate the physics of the real world but rather have a stochastic world model, specifically a stochastic representation of gravity. This contrasts with prior accounts that suggested a potentially noisy Newtonian model where the noise arises from perceptual uncertainty or (inferred) external perturbations. The experimental evidence is generally solid, with all experiments and model simulations being consistent with the proposed account. In the revision, the authors also added a number of control experiments that address some of the most pressing concerns of the original submission.

Reviewed by eLife

Neurofeedback training can modulate task-relevant memory replay rate in rats

1. Anna K Gillespie
2. Daniela Astudillo Maya
3. Eric L Denovellis
4. Sachi Desse
5. Loren M Frank

• Curated by eLife

  eLife assessment

  This study tests the effects of using neurofeedback, in the form of reward delivery when large sharp wave-ripples (SWRs) are detected, on neurophysiological and behavioral measures. The results are important, and the authors provide convincing evidence that the rate of SWRs increased prior to reward delivery and decreased in the period after reward delivery, with no significant effect on memory performance. The ability to manipulate SWR rate in a naturalistic way is an exciting new tool for studies that seek to understand the function of SWRs.

Reviewed by eLife

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

1. Bohan Zhu
2. Richard I Ainsworth
3. Zengmiao Wang
4. Zhengzhi Liu
5. Salvador Sierra
6. Chengyu Deng
7. Luis F Callado
8. J Javier Meana
9. Wei Wang
10. Chang Lu
11. Javier González-Maeso

• Curated by eLife

  eLife assessment

  The study by Zhu et al. provides important insights into cell-specific genome-wide histone modifications in the frontal cortex of individuals with schizophrenia, as well as shedding light on the role of age and antipsychotic treatment in these associations. The evidence supporting the conclusions is solid.

Reviewed by eLife

Plastic vasomotion entrainment

1. Daichi Sasaki
2. Ken Imai
3. Yoko Ikoma
4. Ko Matsui

• Curated by eLife

  eLife assessment

  This manuscript presents important results indicating a plastic enhancement in the vasomotion response of pial cortical arterioles to external stimulation in awake mice using a wide range of external visual stimulation paradigms. The evidence for this interesting effect, with broad potential applications, is solid. These results are relevant for scientists and clinicians interested in the regulation of blood flow in the brain.

Reviewed by eLife

Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

1. Evan D Vickers
2. David A McCormick

• Curated by eLife

  eLife assessment

  This important paper presents a thoroughly detailed methodology for mesoscale-imaging of extensive areas of the cortex, either from a top or lateral perspective, in behaving mice. The examples of scientific results to be derived with this method offer promising and stimulating insights. Overall, the method and results presented are convincing and will be of interest to neuroscientists focused on cortical processing in rodents and beyond.

Reviewed by eLife

Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

1. Blake J Laham
2. Isha R Gore
3. Casey J Brown
4. Elizabeth Gould

• Curated by eLife

  eLife assessment

  This paper reports a valuable set of new results. The main result is that the projection from adult-born granule cells in the dentate gyrus to the hippocampal subfield CA2 is necessary for the retrieval of a social memory formed during development, and solid evidence is provided to support this conclusion.

Reviewed by eLife

Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

1. Alyssa D Huff
2. Marlusa Karlen-Amarante
3. Luiz M Oliveira
4. Jan-Marino Ramirez

• Curated by eLife

  eLife assessment

  This important study represents a follow-up of previous papers by Huff et al. (2023) in which the authors further investigate a specific medullary region named the Postinspiratory Complex (PiCo) involved in the control of swallow behaviour and its coordination with breathing. In the present work, they tested the impact of chronic intermittent hypoxia on the swallow motor pattern evoked by optogenetic stimulation of the same medullary area in transgenic mice. These solid results indicate that in chronic intermittent hypoxia-exposed mice PiCo stimulation triggers atypical swallow motor patterns. The experimental procedures are rigorous and technically remarkable. The work will be of interest in the field of respiratory physiology and pathophysiology since a disruption of swallowing and possibly discoordination with breathing may be involved in diseases characterized by the presence of hypoxic conditions such as obstructive sleep apnea.

Reviewed by eLife

Spontaneous activity of striatal projection neurons supports maturation of striatal inputs to substantia nigra dopaminergic neurons

1. Bojana Kokinovic
2. Patricia Seja
3. Angelica Donati
4. Maria Ryazantseva
5. Alban de Kerchove d’Exaerde
6. Serge N. Schiffmann
7. Tomi Taira
8. Svetlana M. Molchanova

• Curated by eLife

  eLife assessment

  This valuable study describes early postnatal compartmental differences in the functional maturation of striatal projection neurons. It explores how the postnatal activity of these neurons may determine the GABAergic innervation of dopaminergic neurons in the adult substantia nigra pars compacta. While the functional characterization of striatal neuron development is solid, analysis of how early postnatal activity of striatal projection neurons shapes their functional innervation of dopaminergic neurons is incomplete.

Reviewed by eLife

Microglia contact cerebral vasculature through gaps between astrocyte endfeet

1. Gary P Morris
2. Catherine G Foster
3. Brad A Sutherland
4. Søren Grubb

Reviewed by Arcadia Science

Unveiling the cell biology of hippocampal neurons with dendritic axon origin

1. Yuhao Han
2. Daniela Hacker
3. Bronte Catharina Donders
4. Christopher Parperis
5. Roland Thuenauer
6. Christophe Leterrier
7. Kay Grünewald
8. Marina Mikhaylova

Reviewed by Review Commons