Neuroscience

BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase–9 activity

1. Diana Legutko
2. Lukasz Bijoch
3. Grzegorz Olszak
4. Bożena Kuźniewska
5. Katarzyna Kalita
6. Ryohei Yasuda
7. Leszek Kaczmarek
8. Piotr Michaluk

Reviewed by Review Commons

Single-cell RNA sequencing of iPSC-derived brain organoids reveals Treponema pallidum infection inhibiting neurodevelopment

1. Qiu-Yan Xu
2. Yong-Jing Wang
3. Yun He
4. Xin-Qi Zheng
5. Man-Li Tong
6. Yu Lin
7. Tian-Ci Yang

• Curated by eLife

  eLife assessment

  This is a valuable study that describes the effects of T. pallidum on neural development by applying single-cell RNA sequencing to an iPSC-derived brain organoid model. The evidence supporting the claims of the authors is solid, although further evidence to understand the differences in infection rates would strengthen the conclusions of the study. In particular, the conclusions would be strengthened by validating infection efficiency as this can impact the interpretation of single-cell sequencing results, and how these metrics affect organoid size as well as comparison with additional infectious agents. Furthermore, additional functional validations of downstream effectors could be insightful.

Reviewed by eLife

Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models

1. Wing Hei Au
2. Leonor Miller-Fleming
3. Alvaro Sanchez-Martinez
4. James AK Lee
5. Madeleine J Twyning
6. Hiran A Prag
7. Laura Raik
8. Scott P Allen
9. Pamela J Shaw
10. Laura Ferraiuolo
11. Heather Mortiboys
12. Alexander J Whitworth

Reviewed by Review Commons