Neuroscience

Three-photon excited fluorescence microscopy enables imaging of blood flow, neural structure and inflammatory response deep into mouse spinal cord in vivo

1. Yu-Ting Cheng
2. Kawasi M. Lett
3. Chris Xu
4. Chris B. Schaffer

• Curated by eLife

  eLife assessment

  In this work, the authors put forward a valuable methodological advancement for imaging deeper in the intact spinal cord of anaesthetized mice. The authors measured blood flow across different vessel types within the spinal cord and observed the cellular responses following venule occlusion. The demonstration is solid, although, a more quantitative comparison with state-of-the-art two-photon excited fluorescence microscopy and a discussion about applicability to functional imaging (e.g., calcium imaging) would have strengthened the study.

Reviewed by eLife

Light-microscopy-based connectomic reconstruction of mammalian brain tissue

1. Mojtaba R. Tavakoli
2. Julia Lyudchik
3. Michał Januszewski
4. Vitali Vistunou
5. Nathalie Agudelo Dueñas
6. Jakob Vorlaufer
7. Christoph Sommer
8. Caroline Kreuzinger
9. Bárbara Oliveira
10. Alban Cenameri
11. Gaia Novarino
12. Viren Jain
13. Johann G. Danzl

Reviewed by preLights

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

1. Kate E. McCluskey
2. Katherine M. Stovell
3. Karen Law
4. Elina Kostyanovskaya
5. James D. Schmidt
6. Cameron R. T. Exner
7. Jeanselle Dea
8. Elise Brimble
9. Matthew W. State
10. A. Jeremy Willsey
11. Helen Rankin Willsey

Reviewed by preLights

Autism candidate gene rbm-26 ( RBM26/27 ) regulates MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment

1. Tamjid A Chowdhury
2. David A Luy
3. Garrett Scapellato
4. Dorian Farache
5. Amy SY Lee
6. Christopher C Quinn

Reviewed by Review Commons