Neuroscience

Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components

1. Mattias Horan
2. Daniel Regester
3. Cristina Mazuski
4. Thomas Jahans-Price
5. Shanice Bailey
6. Emmett Thompson
7. Zuzanna Slonina
8. Viktor Plattner
9. Elena Menichini
10. Irmak Toksöz
11. Sandra Romero Pinto
12. Mark Burrell
13. Isabella Varsavsky
14. Henry WP Dalgleish
15. Célian Bimbard
16. Anna Lebedeva
17. Marius Bauza
18. Francesca Cacucci
19. Thomas Wills
20. Athena Akrami
21. Julija Krupic
22. Marcus Stephenson-Jones
23. Caswell Barry
24. Neil Burgess
25. John O’Keefe
26. Yoh Isogai

• Curated by eLife

  eLife assessment

  This report details the creation and wide-scale utilization of "Repix", a new technique for chronic neurophysiological recordings using and re-using Neuropixels probes in freely behaving mice and rats. The authors include data and feedback from a variety of labs and researchers who have used this technique, setting an example for open science and reproducibility, and providing convincing evidence that this approach can be employed for chronic Neuropixels recordings. However, evidence is currently incomplete for claims about the advantages of this design over previous approaches and for cell yield and stability claims. This important work will have an impact on a broad range of neuroscientists seeking a straightforward methodology for chronic Neuropixels recordings and will facilitate ethologically relevant experimental designs.

Reviewed by eLife