1. Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI

    This article has 6 authors:
    1. Fan Nils Yang
    2. Dante Picchioni
    3. Jacco A de Zwart
    4. Yicun Wang
    5. Peter van Gelderen
    6. Jeff H Duyn
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work, leveraging state-of-the-art whole-night sleep EEG-fMRI methods, advances our understanding of the brain states underlying sleep and wakefulness. Despite a small sample size, the authors present convincing evidence for substates within N2 and REM sleep stages, with reliable transition structure, supporting the perspective that there are more than the five canonical sleep/wake states.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Predictive models for secondary epilepsy within 1 year in patients with acute ischemic stroke: a multicenter retrospective study

    This article has 10 authors:
    1. Jinxin Liu
    2. Haoyue He
    3. Yanglingxi Wang
    4. Jun Du
    5. Kaixin Liang
    6. Jun Xue
    7. Yidan Liang
    8. Peng Chen
    9. Shanshan Tian
    10. Yongbing Deng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study reports machine learning models derived from large-scale data to predict the risk of post-stroke epilepsy. The evidence supporting the conclusions is, however, incomplete, as many critical methodological aspects have been omitted or described too briefly, the analysis of the results is not complete, and the dataset and code have not been disclosed, which represents an obstacle to reproducibility. The study may be of some interest in the field of clinical neurology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA

    This article has 11 authors:
    1. Aurelie Carabalona
    2. Henna Kallo
    3. Maryanne Gonzalez
    4. Liliia Andriichuk
    5. Ellinoora Elomaa
    6. Florence Molinari
    7. Christiana Fragkou
    8. Pekka Lappalainen
    9. Marja W Wessels
    10. Juha Saarikangas
    11. Claudio Rivera
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable study, the authors examine the role of the cytoskeletal regulatory protein Abba in governing the process of cell genesis in the developing cortex. This study provides insights into the mechanisms of microcephaly, a developmental malformation. The evidence supporting the study was felt to be solid, but the reviewers did note some technical weaknesses that limit the strength of some of the interpretations.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Predicting the causal relationship between polyunsaturated fatty acids and cerebral aneurysm risk from a Mendelian randomization study

    This article has 12 authors:
    1. Weijie Yu
    2. Yunyun Mei
    3. Chongfei Li
    4. Zhenwei Lu
    5. Xiaoyu Chen
    6. Hao Yu
    7. Xiaoyan Chen
    8. Qionghui Huang
    9. Zhangyu Li
    10. Deyong Xiao
    11. Liwei Zhou
    12. Zhanxian Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Yu and colleagues used two-sample MR to test the effect of PUFA on cerebral aneurysms. They found that genetically predicted omega-3 and DHA decreased the risk for Intracranial Aneurysm and Subarachnoid Haemorrhage. This work is useful, although the evidence is incomplete as it lacks a robust set of analyses to provide credibility to the findings.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Plasma extracellular vesicle synaptic proteins as biomarkers of clinical progression in patients with Parkinson’s disease

    This article has 4 authors:
    1. Chien-Tai Hong
    2. Chen-Chih Chung
    3. Ruan-Ching Yu
    4. Lung Chan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study presents data regarding the presence of synaptic proteins in the extracellular vesicle pool present in the blood of Parkinson's patients and non-parkinson neurological outpatients, trying to correlate changes in such levels with the progression of Parkinson's symptoms. The results are semi-quantitative and preliminary, suggesting that these biomarkers could be used in the follow up of a specific group of Parkinson patients. The evidence is incomplete at this point, and more quantitative approaches are required to propose this correlation. The isolation of extracellular vesicles was appropriate as revealed by their sizes, but they are not exclusively from neuronal origin. The presented approach is not ready to be used in the clinical setting.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning

    This article has 26 authors:
    1. Matthew F Wipperman
    2. Allen Z Lin
    3. Kaitlyn M Gayvert
    4. Benjamin Lahner
    5. Selin Somersan-Karakaya
    6. Xuefang Wu
    7. Joseph Im
    8. Minji Lee
    9. Bharatkumar Koyani
    10. Ian Setliff
    11. Malika Thakur
    12. Daoyu Duan
    13. Aurora Breazna
    14. Fang Wang
    15. Wei Keat Lim
    16. Gabor Halasz
    17. Jacek Urbanek
    18. Yamini Patel
    19. Gurinder S Atwal
    20. Jennifer D Hamilton
    21. Samuel Stuart
    22. Oren Levy
    23. Andreja Avbersek
    24. Rinol Alaj
    25. Sara C Hamon
    26. Olivier Harari
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable dataset and tool that can aid in arthropathies' assessment, potentially enabling such evaluation to be done outside the lab. There is solid evidence supporting the comparison between the force plate and insole data, which can be strengthened by improvements in cross-validation, but the evidence for distinguishing disease signatures and elimination of walking speed as a factor is inconclusive and would need further analysis. This work will be of interest to physical therapists, clinicians, and researchers in the field of ankle/knee/hip osteoporosis and other lower limb joint diseases.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Symptom persistence and biomarkers in post-COVID-19/chronic fatigue syndrome – results from a prospective observational cohort

    This article has 13 authors:
    1. A. F. Legler
    2. L. Meyer-Arndt
    3. L. Mödl
    4. C. Kedor
    5. H. Freitag
    6. E. Stein
    7. U. Hoppmann
    8. R. Rust
    9. Frank Konietschke
    10. A. Thiel
    11. F. Paul
    12. C. Scheibenbogen
    13. J. Bellmann-Strobl

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Sleep quality, mental health and circadian rhythms during COVID lockdown – Results from the SleepQuest Study

    This article has 8 authors:
    1. Neil Carrigan
    2. Alfie Wearn
    3. Saba Meky
    4. James Selwood
    5. Hugh D. Piggins
    6. Nicholas Turner
    7. Rosemary Greenwood
    8. Elizabeth Coulthard

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Meningoencephalitis associated with COVID-19: a systematic review

    This article has 7 authors:
    1. Ritwick Mondal
    2. Upasana Ganguly
    3. Shramana Deb
    4. Gourav Shome
    5. Subhasish Pramanik
    6. Deebya Bandyopadhyay
    7. Durjoy Lahiri

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. The clinical spectrum of encephalitis in COVID-19 disease: the ENCOVID multicentre study

    This article has 29 authors:
    1. Andrea Pilotto
    2. Stefano Masciocchi
    3. Irene Volonghi
    4. Elisabetta del Zotto
    5. Eugenio Magni
    6. Valeria De Giuli
    7. Francesca Caprioli
    8. Nicola Rifino
    9. Maria Sessa
    10. Michele Gennuso
    11. Maria Sofia Cotelli
    12. Marinella Turla
    13. Ubaldo Balducci
    14. Sara Mariotto
    15. Sergio Ferrari
    16. Alfonso Ciccone
    17. Fabrizio Fiacco
    18. Alberto Imarisio
    19. Barbara Risi
    20. Alberto Benussi
    21. Enrico Premi
    22. Emanuele Focà
    23. Francesca Caccuri
    24. Matilde Leonardi
    25. Roberto Gasparotti
    26. Francesco Castelli
    27. Gianluigi Zanusso
    28. Alessandro Pezzini
    29. Alessandro Padovani

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity