1. PIE-1 promotes SUMOylation and activation of HDAC1 during the C. elegans oogenesis

    This article has 7 authors:
    1. Heesun Kim
    2. Yue-He Ding
    3. Shan Lu
    4. Mei-Qing Zuo
    5. Darryl Conte
    6. Meng-Qiu Dong
    7. Craig C. Mello
    This article has been curated by 1 group:
    • Curated by eLife

      Summary: In this paper you describe experiments showing that PIE-1 is sumoylated at K68, and that K68 sumoylation plays a role in PIE-1 interaction with HDA-1 and its sumoylation, which leads to its activation. The reviewers found the sumoylation dependence of PIE-1 function in piRNA silencing to be of interest, but raised major issues that need to be addressed. In particular, more mechanistic insights into how sumoylation of PIE-1 at K68 enhances HDA-1 sumoylation and regulation are required.

      This is a co-submission with the manuscript https://www.biorxiv.org/content/10.1101/2020.08.17.254466v2

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

    This article has 7 authors:
    1. Heesun Kim
    2. Yue-He Ding
    3. Gangming Zhang
    4. Yong-Hong Yan
    5. Darryl Conte
    6. Meng-Qiu Dong
    7. Craig C Mello
    This article has been curated by 1 group:
    • Curated by eLife

      Summary: In this paper, your studies showed that sumoylation of HDA-1, a type 1 HDAC, at two C-terminal Lys residues plays a role in establishing transcriptional silencing of piRNA-regulated genes in C. elegans through enhanced NuRD complex interaction and histone H3 deacetylation. The reviewers all found the link between HDA-1 sumoylation and silencing to be interesting, but raised a number of issues that need to be addressed.

      This is a co-submission with the manuscript https://www.biorxiv.org/content/10.1101/2020.08.17.254466v2

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis

    This article has 14 authors:
    1. Huascar Pedro Ortuste Quiroga
    2. Massimo Ganassi
    3. Shingo Yokoyama
    4. Kodai Nakamura
    5. Tomohiro Yamashita
    6. Daniel Raimbach
    7. Arisa Hagiwara
    8. Oscar Harrington
    9. Jodie Breach-Teji
    10. Atsushi Asakura
    11. Yoshiro Suzuki
    12. Makoto Tominaga
    13. Peter S. Zammit
    14. Katsumasa Goto

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Basis of specificity for a conserved and promiscuous chromatin remodeling protein

    This article has 9 authors:
    1. Drake A Donovan
    2. Johnathan G Crandall
    3. Vi N Truong
    4. Abigail L Vaaler
    5. Thomas B Bailey
    6. Devin Dinwiddie
    7. Orion GB Banks
    8. Laura E McKnight
    9. Jeffrey N McKnight

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. SUV39 SET domains mediate crosstalk of heterochromatic histone marks

    This article has 8 authors:
    1. Alessandro Stirpe
    2. Nora Guidotti
    3. Sarah J Northall
    4. Sinan Kilic
    5. Alexandre Hainard
    6. Oscar Vadas
    7. Beat Fierz
    8. Thomas Schalch

    Reviewed by eLife, preLights

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  6. DHX30 Coordinates Cytoplasmic Translation and Mitochondrial Function Contributing to Cancer Cell Survival

    This article has 13 authors:
    1. Bartolomeo Bosco
    2. Annalisa Rossi
    3. Dario Rizzotto
    4. Meriem Hadjer Hamadou
    5. Alessandra Bisio
    6. Sebastiano Giorgetta
    7. Alicia Perzolli
    8. Francesco Bonollo
    9. Angeline Gaucherot
    10. Frédéric Catez
    11. Jean-Jacques Diaz
    12. Erik Dassi
    13. Alberto Inga

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Fitness landscape of a dynamic RNA structure

    This article has 4 authors:
    1. Valerie W. C. Soo
    2. Jacob B. Swadling
    3. Andre J. Faure
    4. Tobias Warnecke

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. CUT&RUN detects distinct DNA footprints of RNA polymerase II near the transcription start sites

    This article has 2 authors:
    1. Michi Miura
    2. Honglin Chen

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. Nucleus translocation of tRNA synthetase mediates late integrated stress response

    This article has 7 authors:
    1. Na Wei
    2. Haissi Cui
    3. Yi Shi
    4. Guangsen Fu
    5. Navin Rauniyar
    6. John R. Yates
    7. Xiang-Lei Yang

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. SON and SRRM2 are essential for nuclear speckle formation

    This article has 6 authors:
    1. İbrahim Avşar Ilik
    2. Michal Malszycki
    3. Anna Katharina Lübke
    4. Claudia Schade
    5. David Meierhofer
    6. Tuğçe Aktaş

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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