Molecular Biology

  1. SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India

    1. Sarah Cherian
    2. Varsha Potdar
    3. Santosh Jadhav
    4. Pragya Yadav
    5. Nivedita Gupta
    6. Mousumi Das
    7. Partha Rakshit
    8. Sujeet Singh
    9. Priya Abraham
    10. Samiran Panda
    11. NIC Team

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. One-pot Detection of COVID-19 with Real-time Reverse-transcription Loop-mediated Isothermal Amplification (RT-LAMP) Assay and Visual RT-LAMP Assay

    1. Deguo Wang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. A Rapid, Highly Sensitive and Open-Access SARS-CoV-2 Detection Assay for Laboratory and Home Testing

    1. Max J. Kellner
    2. James J. Ross
    3. Jakob Schnabl
    4. Marcus P. S. Dekens
    5. Martin Matl
    6. Robert Heinen
    7. Irina Grishkovskaya
    8. Benedikt Bauer
    9. Johannes Stadlmann
    10. Luis Menéndez-Arias
    11. Andrew D. Straw
    12. Robert Fritsche-Polanz
    13. Marianna Traugott
    14. Tamara Seitz
    15. Alexander Zoufaly
    16. Manuela Födinger
    17. Christoph Wenisch
    18. Johannes Zuber
    19. Vienna COVID-19 Detection Initiative (VCDI)
    20. Andrea Pauli
    21. Julius Brennecke

    Reviewed by ScreenIT

    2 evaluationsAppears in 1 listLatest version Latest activity

  4. A Scalable, Easy-to-Deploy Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material

    1. Jennifer N. Rauch
    2. Eric Valois
    3. Sabrina C. Solley
    4. Friederike Braig
    5. Ryan S. Lach
    6. Morgane Audouard
    7. Jose Carlos Ponce-Rojas
    8. Michael S. Costello
    9. Naomi J. Baxter
    10. Kenneth S. Kosik
    11. Carolina Arias
    12. Diego Acosta-Alvear
    13. Maxwell Z. Wilson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

    1. Ilhame Diboun
    2. Sachin Wani
    3. Stuart H Ralston
    4. Omar ME Albagha

    • Curated by eLife

      Evaluation Summary:

      Paget disease of bone (PDB) results in focal areas of disorganized bone, leading to bone deformities and fragility. There is substantial interest in finding circulating biomarkers that might be of use for possible diagnostic applications and towards this end, these authors identified novel DNA methylation patterns in peripheral blood mononuclear cells that are able to differentiate PDB cases from controls with a high level of accuracy. This prediction model has functional relevance as these candidate methylation sites and regions are associated with osteological and immunologic processes and in the longer term, has future clinical potential.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Targeting circPTPN12/miR-21-5p/ΔNp63α pathway as a therapeutic strategy for human endometrial fibrosis

    1. Minmin Song
    2. Guangfeng Zhao
    3. Haixiang Sun
    4. Simin Yao
    5. Zhenhua Zhou
    6. Peipei Jiang
    7. Qianwen Wu
    8. Hui Zhu
    9. Huiyan Wang
    10. Chenyan Dai
    11. Jingmei Wang
    12. Ruotian Li
    13. Yun Cao
    14. Haining lv
    15. Dan Liu
    16. Jianwu Dai
    17. Yan Zhou
    18. Yali Hu

    • Curated by eLife

      Evaluation Summary:

      The study by Song and colleagues explores the role of circRNAs in fibrosis of the endometrium. The paper is of interest for scientists working in the field of endometrial fibrosis and most likely can have implications for other endometrial disorders characterised by fibrotic tissues. The study unravel the molecular mechanism underlying the disease and the thorough experimental part fully support the author's claim.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry

    1. Christine E Cucinotta
    2. Rachel H Dell
    3. Keean CA Braceros
    4. Toshio Tsukiyama

    • Curated by eLife

      Evaluation Summary:

      Cucinotta et al. describe mechanisms that support an intense burst of transcription from many genes within minutes of nutrient repletion as Saccharomyces cerevisiae cells emerge from quiescence. They focus primarily on the role of the nucleosome remodeler RSC in managing chromatin architecture over promoters during quiescence and as cells re-enter the cell cycle using a broad range of genome-wide measurements that strongly support the conclusions. This important process of cell cycle re-entry from quiescence is understudied but impacts areas as diverse as development and carcinogenesis in multicellular organisms to long-term survival and adaptation of microorganisms to environmental cues, so the results will be of interest to a broad audience.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. The trypanosome Variant Surface Glycoprotein mRNA is stabilized by an essential unconventional RNA-binding protein

    1. Larissa Melo do Nascimento
    2. Franziska Egler
    3. Katharina Arnold
    4. Nina Papavisiliou
    5. Christine Clayton
    6. Esteban Erben

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    1. Yang Zhang
    2. Gerd Bobe
    3. Cristobal L Miranda
    4. Malcolm B Lowry
    5. Victor L Hsu
    6. Christiane V Lohr
    7. Carmen P Wong
    8. Donald B Jump
    9. Matthew M Robinson
    10. Thomas J Sharpton
    11. Claudia S Maier
    12. Jan F Stevens
    13. Adrian F Gombart

    • Curated by eLife

      Evaluation Summary:

      This is a comprehensive study of the effect of xanthohumol and TXN, a xanthohumol derivative, on different pathologies related to the metabolic syndrome. It clearly shows the therapeutic potential of these substances, which has a high translational potential since currently, there are is a lack of effective therapies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. No Evidence of Coronaviruses or Other Potentially Zoonotic Viruses in Sunda pangolins (Manis javanica) Entering the Wildlife Trade via Malaysia

    1. Jimmy Lee
    2. Tom Hughes
    3. Mei-Ho Lee
    4. Hume Field
    5. Jeffrine Japning Rovie-Ryan
    6. Frankie Thomas Sitam
    7. Symphorosa Sipangkui
    8. Senthilvel K. S. S. Nathan
    9. Diana Ramirez
    10. Subbiah Vijay Kumar
    11. Helen Lasimbang
    12. Jonathan H. Epstein
    13. Peter Daszak

    Reviewed by ScreenIT, NCRC

    3 evaluationsAppears in 2 listsLatest version Latest activity
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