Microbiology

Deep learning image analysis for filamentous fungi taxonomic classification: Dealing with small datasets with class imbalance and hierarchical grouping

1. Stefan Stiller
2. Juan F Dueñas
3. Stefan Hempel
4. Matthias C Rillig
5. Masahiro Ryo

Reviewed by Arcadia Science

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

1. C.R. Plumlee
2. H.W. Barrett
3. D.E. Shao
4. K.A. Lien
5. L.M. Cross
6. S.B. Cohen
7. P.T Edlefsen
8. K.B. Urdahl

Reviewed by Review Commons

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

1. Hsiao-Fan Chen
2. Wei-Jan Wang
3. Chung-Yu Chen
4. Wei-Chao Chang
5. Po-Ren Hsueh
6. Shin-Lei Peng
7. Chen-Shiou Wu
8. Yeh Chen
9. Hsin-Yu Huang
10. Wan-Jou Shen
11. Shao-Chun Wang
12. Mien-Chie Hung

• Curated by eLife

  eLife assessment

  This fundamental work provides preclinical evidence to support that natural tannins derived from grapeseed can inhibit or prevent infection by the SARS-CoV-2 viruses. The evidence provided is mostly solid to convincing and supports the conclusions. This work will be of broad interest to cell biologists and physicians.

Reviewed by eLife

Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

1. Alexander Lobanov
2. Samantha Dyckman
3. Helen Kurkjian
4. Babak Momeni

• Curated by eLife

  eLife assessment

  This important study uses computational simulations to explore how spatial structure can affect the coexistence between different microbial species, ultimately helping to explain diversity in microbial communities. The evidence supporting the conclusions is solid, although the parameter values used in the simulations were deemed to be unrealistic. Further investigation on whether the conclusions would hold under more realistic assumptions would be very interesting to microbial ecologists quite broadly.

Reviewed by eLife

Enterococcus faecalis strains with compromised CRISPR-Cas defense emerge under antibiotic selection for a CRISPR-targeted plasmid

1. Wenwen Huo
2. Valerie J. Price
3. Ardalan Sharifi
4. Michael Q. Zhang
5. Kelli L. Palmer

Reviewed by Arcadia Science

Bioactive exometabolites drive maintenance competition in simple bacterial communities

1. John L. Chodkowski
2. Ashley Shade

Reviewed by Arcadia Science

Arrive and wait: Inactive bacterial taxa contribute to perceived soil microbiome resilience after a multidecadal press disturbance

1. Samuel E. Barnett
2. Ashley Shade

Reviewed by Arcadia Science

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

1. Lukáš V. F. Novák
2. Sebastian C. Treitli
3. Jan Pyrih
4. Paweł Hałakuc
5. Shweta V. Pipaliya
6. Vojtěch Vacek
7. Ondřej Brzoň
8. Petr Soukal
9. Laura Eme
10. Joel B. Dacks
11. Anna Karnkowska
12. Marek Eliáš
13. Vladimír Hampl

Reviewed by Review Commons

Oxidative stress changes interactions between two bacterial species

1. Rita Di Martino
2. Aurore Picot
3. Sara Mitri

Reviewed by Arcadia Science

Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis

1. Jonas Maurice Holzinger
2. Martina Toelge
3. Maren Werner
4. Katharina Ursula Ederer
5. Heiko Ingo Siegmund
6. David Peterhoff
7. Stefan Helmut Blaas
8. Nicolas Gisch
9. Christoph Brochhausen
10. André Gessner
11. Sigrid Bülow

• Curated by eLife

  eLife assessment

  In this useful study, Holzinger et al. present compelling evidence that scorpionfish bactericidal/permeability-increasing protein (scoBPI) exhibits remarkable antibacterial activity against multi-drug resistant Pseudomonas aeruginosa. These findings open new avenues of research for identifying novel chemotherapies to treat Pseudomonas infections and have broader implications in developing chemotherapies against other drug-resistant Gram-negative bacterial infections. The work will be of interest to individuals investigating novel cystic fibrosis antimicrobials.

Reviewed by eLife