Microbiology

A lung-on-chip model reveals an essential role for alveolar epithelial cells in controlling bacterial growth during early tuberculosis

1. Vivek V. Thacker
2. Neeraj Dhar
3. Kunal Sharma
4. Riccardo Barrile
5. Katia Karalis
6. John D. McKinney

Reviewed by eLife, preLights

A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites

1. David W. Cobb
2. Heather M. Kudyba
3. Alejandra Villegas
4. Michael R. Hoopmann
5. Rodrigo P. Baptista
6. Baylee Bruton
7. Michelle Krakowiak
8. Robert L. Moritz
9. Vasant Muralidharan

Reviewed by eLife

Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats

1. Anitha D. Jayaprakash
2. Adam J. Ronk
3. Abhishek N. Prasad
4. Michael F. Covington
5. Kathryn R. Stein
6. Toni M. Schwarz
7. Saboor Hekmaty
8. Karla A. Fenton
9. Thomas W. Geisbert
10. Christopher F. Basler
11. Alexander Bukreyev
12. Ravi Sachidanandam

Reviewed by Review Commons

Functional reconstitution of a bacterial CO ₂ concentrating mechanism in E. coli

1. Avi I. Flamholz
2. Eli Dugan
3. Cecilia Blikstad
4. Shmuel Gleizer
5. Roee Ben-Nissan
6. Shira Amram
7. Niv Antonovsky
8. Sumedha Ravishankar
9. Elad Noor
10. Arren Bar-Even
11. Ron Milo
12. David F. Savage

Reviewed by eLife

Second messenger control of mRNA translation by dynamic ribosome modification

1. Lucia Grenga
2. Richard Howard Little
3. Govind Chandra
4. Stuart Daniel Woodcock
5. Gerhard Saalbach
6. Richard James Morris
7. Jacob George Malone

Reviewed by Review Commons

Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

1. Jun Kurushima
2. Nathalie Campo
3. Renske van Raaphorst
4. Guillaume Cerckel
5. Patrice Polard
6. Jan-Willem Veening

Reviewed by eLife

Proline catabolism is key to facilitating Candida albicans pathogenicity

1. Fitz Gerald S. Silao
2. Tong Jiang
3. Biborka Bereczky-Veress
4. Andreas Kühbacher
5. Kicki Ryman
6. Nathalie Uwamohoro
7. Sabrina Jenull
8. Filomena Nogueira
9. Meliza Ward
10. Thomas Lion
11. Constantin F. Urban
12. Steffen Rupp
13. Karl Kuchler
14. Changbin Chen
15. Christiane Peuckert
16. Per O. Ljungdahl

Reviewed by Review Commons

Influenza virus transcription and progeny production are poorly correlated in single cells

1. David J Bacsik
2. Bernadeta Dadonaite
3. Andrew Butler
4. Allison J Greaney
5. Nicholas S Heaton
6. Jesse D Bloom

• Curated by eLife

  eLife assessment

  This important paper reports a novel, compelling method, based on barcoding viral genes and next-generation sequencing, to quantify both viral transcription levels and progeny virus production in influenza virus-infected cells at the single-cell level. The authors show that viral transcription and progeny virus production are unexpectedly poorly correlated, and that cells in which viral RNAs are transcribed at high levels are not necessarily those producing the most progeny virions. Because of its novelty, the study will be of interest to the broader virology community.

Reviewed by eLife

Spatial and temporal dynamics of SAR11 marine bacteria sampled across a nearshore to offshore transect in the tropical Pacific Ocean

1. Sarah J. Tucker
2. Kelle C. Freel
3. Elizabeth A. Monaghan
4. Clarisse E.S. Sullivan
5. Oscar Ramfelt
6. Yoshimi M. Rii
7. Michael S. Rappé

Reviewed by PeerJ

A single laccase acts as a key component of environmental sensing in a broad host range fungal pathogen

1. Nathaniel M. Westrick
2. Eddie G. Dominguez
3. Madeline Bondy
4. Christina M. Hull
5. Damon L. Smith
6. Mehdi Kabbage

Reviewed by preLights