Microbiology

Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera

1. Xuping Xie
2. Jing Zou
3. Camila R. Fontes-Garfias
4. Hongjie Xia
5. Kena A. Swanson
6. Mark Cutler
7. David Cooper
8. Vineet D. Menachery
9. Scott Weaver
10. Philip R. Dormitzer
11. Pei-Yong Shi

Reviewed by ScreenIT, Rapid Reviews Infectious Diseases, NCRC

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

1. E.I. Patterson
2. G. Elia
3. A. Grassi
4. A. Giordano
5. C. Desario
6. M. Medardo
7. S.L. Smith
8. E.R. Anderson
9. T. Prince
10. G.T. Patterson
11. E. Lorusso
12. M.S. Lucente
13. G. Lanave
14. S. Lauzi
15. U. Bonfanti
16. A. Stranieri
17. V. Martella
18. F. Solari Basano
19. V.R. Barrs
20. A.D. Radford
21. U. Agrimi
22. G. L. Hughes
23. S. Paltrinieri
24. N. Decaro

Reviewed by ScreenIT, NCRC

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

1. Leonid Yurkovetskiy
2. Xue Wang
3. Kristen E. Pascal
4. Christopher Tomkins-Tinch
5. Thomas P. Nyalile
6. Yetao Wang
7. Alina Baum
8. William E. Diehl
9. Ann Dauphin
10. Claudia Carbone
11. Kristen Veinotte
12. Shawn B. Egri
13. Stephen F. Schaffner
14. Jacob E. Lemieux
15. James B. Munro
16. Ashique Rafique
17. Abhi Barve
18. Pardis C. Sabeti
19. Christos A. Kyratsous
20. Natalya V. Dudkina
21. Kuang Shen
22. Jeremy Luban

Reviewed by ScreenIT, NCRC

Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection

1. Conrad M. Freuling
2. Angele Breithaupt
3. Thomas Müller
4. Julia Sehl
5. Anne Balkema-Buschmann
6. Melanie Rissmann
7. Antonia Klein
8. Claudia Wylezich
9. Dirk Höper
10. Kerstin Wernike
11. Andrea Aebischer
12. Donata Hoffmann
13. Virginia Friedrichs
14. Anca Dorhoi
15. Martin H. Groschup
16. Martin Beer
17. Thomas C. Mettenleiter

Reviewed by ScreenIT, NCRC

Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa

1. Stuart D. Woodcock
2. Karl Syson
3. Richard H. Little
4. Despoina Sifouna
5. James K.M. Brown
6. Stephen Bornemann
7. Jacob G. Malone

Reviewed by Review Commons

A mobile genetic element increases bacterial host fitness by manipulating development

1. Joshua M. Jones
2. Ilana Grinberg
3. Avigdor Eldar
4. Alan D. Grossman

• Curated by eLife

  Evaluation Summary:

  All the reviewers were in agreement that this is an exceptionally rigorous paper that sets an important precedent for how mobile genetic elements can influence host biology.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

1. Thomas P. Burke
2. Patrik Engström
3. Cuong J. Tran
4. Dustin R. Glasner
5. Diego A. Espinosa
6. Eva Harris
7. Matthew D. Welch

Reviewed by Review Commons

Differential response of macrophages and neutrophils to trypanosome infections in zebrafish: occurrence of foamy macrophages

1. Sem H. Jacobs
2. Éva Dóró
3. Ffion R. Hammond
4. Mai E. Nguyen-Chi
5. Georges Lutfalla
6. Geert F. Wiegertjes
7. Maria Forlenza

• Curated by eLife

  Summary: This study investigates the role of the innate immune response in controlling bloodstream trypanosome infection in the zebrafish infection model recently developed by the authors. The study found that an innate immune response, characterized by controlled inflammatory response was sufficient to control infection in some individuals, while failure to control infection was associated with a strong inflammatory response characterized by expansion of foamy macrophages. The findings highlight the importance of a balanced immune response in controlling bloodstream trypanosome infections that are likely relevant to mammalian infections.

  Reviewer #1 and Reviewer #2 opted to reveal their name to the authors in the decision letter after review.

Reviewed by eLife

Collateral Sensitivity Associated with Antibiotic Resistance Plasmids

1. Cristina Herencias
2. Jerónimo Rodríguez-Beltrán
3. Ricardo León-Sampedro
4. Aida Alonso-del Valle
5. Jana Palkovičová
6. Rafael Cantón
7. Álvaro San Millán

Reviewed by eLife

The Clostridioides difficile species problem: global phylogenomic analysis uncovers three ancient, toxigenic, genomospecies

1. Daniel R. Knight
2. Korakrit Imwattana
3. Brian Kullin
4. Enzo Guerrero-Araya
5. Daniel Paredes-Sabja
6. Xavier Didelot
7. Kate E. Dingle
8. David W. Eyre
9. César Rodríguez
10. Thomas V. Riley

• Curated by eLife

  Summary: We appreciate this study and find that the conclusions that reclassify Clostridiodes are largely justified by the data/analysis. The major concern is that the work represents the application of standard approaches to refine species classification, as opposed to either proposing a novel approach to classify species or defining a split that might be more surprising and/or clinically significant (e.g. Kumar et al. Nature Genetics, 2019). Consequently, despite being a useful contribution to the literature we believe it is more suitable for a specialized audience.

  Reviewer #1 opted to reveal their name to the authors in the decision letter after review.

Reviewed by eLife