Immunology

Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling

1. Rafaela M Guimarães
2. Conceição E Aníbal-Silva
3. Marcela Davoli-Ferreira
4. Francisco Isaac F Gomes
5. Atlante Mendes
6. Maria CM Cavallini
7. Miriam M Fonseca
8. Samara Damasceno
9. Larissa P Andrade
10. Marco Colonna
11. Cyril Rivat
12. Fernando Q Cunha
13. José C Alves-Filho
14. Thiago M Cunha

• Curated by eLife

  Evaluation Summary:

  Guimaraes et al address the origin of the macrophage increase in sensory ganglia after peripheral nerve injury. The authors show that there is no major influx by blood-derived monocytes into ganglia after injury and that resident macrophages proliferate, which is dependent on CX3CR1 signaling. Overall the work is clear and sound and should be of interest to immunologists and neurobiologists.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

The Nucleocapsid Protein Of SARS-CoV-2, Combined With ODN-39M, Is A Potential Component For An Intranasal Bivalent Pancorona Vaccine

1. Yadira Lobaina
2. Rong Chen
3. Edith Suzarte
4. Panchao Ai
5. Vivian Huerta
6. Alexis Musacchio
7. Ricardo Silva
8. Changyuan Tan
9. Alejandro Martin
10. Laura Lazo
11. Gerardo Guillén
12. Ke Yang
13. Yasser Perera
14. Lisset Hermida

Reviewed by ScreenIT

Antiviral immune responses, cellular metabolism and adhesion are differentially modulated by SARS-CoV-2 ORF7a or ORF7b

1. Tránsito García-García
2. Raúl Fernández-Rodríguez
3. Natalia Redondo
4. Ana de Lucas-Rius
5. Sara Zaldívar-López
6. Blanca Dies López-Ayllón
7. José M. Suárez-Cárdenas
8. Ángeles Jiménez-Marín
9. María Montoya
10. Juan J. Garrido

Reviewed by ScreenIT

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

1. Florian Gaertner
2. Hellen Ishikawa-Ankerhold
3. Susanne Stutte
4. Wenwen Fu
5. Chenglong Guo
6. Jutta Weitz
7. Anne Dueck
8. Zhe Zhang
9. Dominic van den Heuvel
10. Valeria Fumagalli
11. Michael Lorenz
12. Louisa von Baumgarten
13. Konstantin Stark
14. Tobias Straub
15. Saskia von Stillfried
16. Peter Boor
17. Marco Colonna
18. Christian Schulz
19. Thomas Brocker
20. Barbara Walzog
21. Christoph Scheiermann
22. Stefan Engelhardt
23. William C. Aird
24. Tobias Petzold
25. Michael Sixt
26. Martina Rudelius
27. Claus Nerlov
28. Matteo Iannacone
29. Robert A. J. Oostendorp
30. Steffen Massberg

Reviewed by ScreenIT

Potentiating the cross-reactive IFN-γ T cell and polyfunctional T cell responses by heterologous GX-19N DNA booster in mice primed with either a COVID-19 mRNA vaccine or inactivated vaccine

1. Yong Bok Seo
2. Ara Ko
3. Duckhyang Shin
4. Junyoung Kim
5. You Suk Suh
6. Juyoung Na
7. Ji In Ryu
8. Young Chul Sung

Reviewed by ScreenIT

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

1. Si Sun
2. Entao Li
3. Gan Zhao
4. Jie Tang
5. Qianfei Zuo
6. Larry Cai
7. Chuanfei Xu
8. Cheng Sui
9. Yangxue Ou
10. Chang Liu
11. Haibo Li
12. Yuan Ding
13. Chao Li
14. Dongshui Lu
15. Weijun Zhang
16. Ping Luo
17. Ping Cheng
18. Yuwei Gao
19. Changchun Tu
20. Bruno Pitard
21. Joseph Rosenecker
22. Bin Wang
23. Yan Liu
24. Quanming Zou
25. Shan Guan

Reviewed by ScreenIT

Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

1. Yuexin Wang
2. Hui Yang
3. Anna Jia
4. Yufei Wang
5. Qiuli Yang
6. Yingjie Dong
7. Yueru Hou
8. Yejin Cao
9. Lin Dong
10. Yujing Bi
11. Guangwei Liu

• Curated by eLife

  Evaluation Summary:

  Wang and colleagues report that the expression of Piezo1 (an ion channel and mechanical sensor) is upregulated on dendritic cells (DC) under conditions of inflammation/high environmental stiffness resulting in DC activation, maturation, and skewing in DC functional polarity and metabolism. They show that Piezo1 knockout results in faster tumor progression and accumulation of more regulatory T cells, and that Smad3 and STAT4 are involved in DC-mediated differentiation of Th1 and Treg. Overall this represents a mechanistic advance in our understanding of DC biology as it relates to cancer and other human pathologies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

1. Valentina Stolz
2. Rafael de Freitas e Silva
3. Ramona Rica
4. Ci Zhu
5. Teresa Preglej
6. Patricia Hamminger
7. Daniela Hainberger
8. Marlis Alteneder
9. Lena Müller
10. Monika Waldherr
11. Darina Waltenberger
12. Anastasiya Hladik
13. Benedikt Agerer
14. Michael Schuster
15. Tobias Frey
16. Thomas Krausgruber
17. Sylvia Knapp
18. Clarissa Campbell
19. Klaus Schmetterer
20. Michael Trauner
21. Andreas Bergthaler
22. Christoph Bock
23. Nicole Boucheron
24. Wilfried Ellmeier

• Curated by eLife

  Evaluation Summary:

  The study shows that the LXRbeta - NCOR1 axis restricts the terminal differentiation of Treg cells into effector Tregs. It also suggests that, in addition to an impact on effector Treg differentiation, loss of NCOR1 leads to impaired suppression function in Treg cells. The results may contribute to our understanding of Treg cell differentiation and function.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

1. Jacob A Van Winkle
2. Stefan T Peterson
3. Elizabeth A Kennedy
4. Michael J Wheadon
5. Harshad Ingle
6. Chandni Desai
7. Rachel Rodgers
8. David A Constant
9. Austin P Wright
10. Lena Li
11. Maxim N Artyomov
12. Sanghyun Lee
13. Megan T Baldridge
14. Timothy J Nice

• Curated by eLife

  Evaluation Summary:

  The paper provides information about the relative importance of the type I and type III interferon-driven gene expression and anti-viral responses, particularly focused on the role of the Intestinal microbiota to maintain background levels of type III (interferon lambda) signaling. Type III-driven gene expression is highly discontinuous in the epithelial layer and mainly at the villous tips with consequent effects on the kinetics of rotavirus model infections.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.)

Reviewed by eLife

Towards a unified model of naive T cell dynamics across the lifespan

1. Sanket Rane
2. Thea Hogan
3. Edward Lee
4. Benedict Seddon
5. Andrew J Yates

• Curated by eLife

  Evaluation Summary:

  This paper is of broad interest to cellular biologists and immunologists. It offers new insights into how T cell compartments are regulated in vivo defining a new perspective on how the T cell compartment is regulated to maintain immune homeostasis and afford long-term immune protection. By assessing data from a range of mouse model systems, the key deduction is that a simple hypothesis, one which notably does not have complex feedback regulation of cell numbers, provides a remarkably good explanation of the data.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife