Immunology

Candida albicans promotes neutrophil extracellular trap formation and leukotoxic hypercitrullination via the peptide toxin candidalysin

1. Lucas Unger
2. Emelie Backman
3. Borko Amulic
4. Fernando M. Ponce-Garcia
5. Sujan Yellagunda
6. Renate Krüger
7. Horst von Bernuth
8. Johan Bylund
9. Bernhard Hube
10. Julian R. Naglik
11. Constantin F. Urban

Reviewed by Review Commons

Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice

1. Elisa Balmas
2. Batika MJ Rana
3. Russell S Hamilton
4. Norman Shreeve
5. Jens Kieckbusch
6. Irving Aye
7. Delia A Hawkes
8. Sophie Trotter
9. Jorge López-Tello
10. Hannah EJ Yong
11. Salvatore Valenti
12. Amanda N Sferruzi-Perri
13. Francesca Gaccioli
14. Andrew NJ McKenzie
15. Francesco Colucci

• Curated by eLife

  eLife assessment

  This important study describes the protective role of group 2 innate lymphoid cells (ILC2s) in tissue physiology and contributes to immunity, inflammatory pathology, and metabolism in maintaining homeostasis during pregnancy. The authors provide convincing evidence that ILC2s have new roles distinct from parasite protection and allergy inducers. Uterine ILC2s are key immune cells during normal and complicated pregnancies.

Reviewed by eLife

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

1. Yu Li
2. Pablo Guaman Tipan
3. Hilary J Selden
4. Jayashree Srinivasan
5. Laura P Hale
6. Lauren IR Ehrlich

• Curated by eLife

  eLife assessment

  This paper will be of broad interest to immunologists that study T cell responses and formation of the peripheral T cell compartment. Using elegant live imaging approaches, the authors provide convincing evidence in support of a revised model for how positive-selected thymocytes are called to the thymus medulla to interact with distinct antigen-presenting cells. The work makes an important contribution to the field by identifying previously unappreciated complexities related to cellular movement during T cell generation.

Reviewed by eLife

Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary multiplexing and mass spectrometry imaging approaches

1. Benjamin L. Oyler
2. Jeferson A. Valencia-Dávila
3. Eirini Moysi
4. Adam Molyvdas
5. Kalliopi Ioannidou
6. Kylie March
7. David Ambrozak
8. Laurence de Leval
9. Giulia Fabozzi
10. Amina S. Woods
11. Richard A. Koup
12. Constantinos Petrovas

Reviewed by Arcadia Science

Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1

1. Kazuki Nagata
2. Sanae Araumi
3. Daisuke Ando
4. Naoto Ito
5. Miki Ando
6. Yuki Ikeda
7. Miki Takahashi
8. Sakura Noguchi
9. Yayoi Yasuda
10. Nobuhiro Nakano
11. Tomoaki Ando
12. Mutsuko Hara
13. Takuya Yashiro
14. Masakazu Hachisu
15. Chiharu Nishiyama

Reviewed by Arcadia Science

Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

1. Jie Wang
2. Amir Rattner
3. Jeremy Nathans

• Curated by eLife

  eLife assessment

  This study presents valuable findings on the changes of immune cell populations and stromal cells occurring at the CNS borders in a neonatal bacterial meningitis model, focusing on fibroblasts, macrophages and endothelial cells. The study provides solid snRNA-seq dataset and high quality immune fluorescence images of dissected brain border regions, that will be useful for the community. These observations and datasets will be of interest to the neuro-immunology community.

Reviewed by eLife

Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

1. Godfrey S Temba
2. Nadira Vadaq
3. Vesla Kullaya
4. Tal Pecht
5. Paolo Lionetti
6. Duccio Cavalieri
7. Joachim L Schultze
8. Reginald Kavishe
9. Leo AB Joosten
10. Andre J van der Ven
11. Blandina T Mmbaga
12. Mihai G Netea
13. Quirijn de Mast

• Curated by eLife

  eLife assessment

  Non-communicable diseases (NCDs) are rising rapidly in urbanizing populations in many parts of the developing world, including in sub-Saharan Africa. Temba and colleagues show important evidence that healthy Tanzanians display a pro-inflammatory phenotype with enrichment of specific immune-metabolic pathways. Dood-derived metabolites were identified as an important driver of inflammation-related molecules. These findings provide solid evidence that the dietary transition that occurs in urbanizing areas in sub-Saharan Africa may contribute significantly to the increased incidence of non communicable diseases in this part of the world.

Reviewed by eLife

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

1. Jiang Li
2. Rebecca E Ruggiero-Ruff
3. Yuxin He
4. Xinru Qiu
5. Nancy Lainez
6. Pedro Villa
7. Adam Godzik
8. Djurdjica Coss
9. Meera G Nair

• Curated by eLife

  eLife assessment

  In this study, Li and al describe valuable insights into the mechanisms underlying sex-differences diet-induced obesity in mice, with a role of macrophage-derived RELMa secretion in female-specific protection. They provide solid evidence for the impact of RELMa signaling in eosinophil recruitment for diet-induced obesity protection in female mice. Single-cell RNA-seq analysis of the stromal vascular fraction of control and RELMa deficient animals methods were used to investigate molecular mechanisms underlying the protection as a powerful method, although the analysis of this data is difficult to evaluate with incomplete methodological information.

Reviewed by eLife

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

1. Yaeko Nakajima-Takagi
2. Motohiko Oshima
3. Junichiro Takano
4. Shuhei Koide
5. Naoki Itokawa
6. Shun Uemura
7. Masayuki Yamashita
8. Shohei Andoh
9. Kazumasa Aoyama
10. Yusuke Isshiki
11. Daisuke Shinoda
12. Atsunori Saraya
13. Fumio Arai
14. Kiyoshi Yamaguchi
15. Yoichi Furukawa
16. Haruhiko Koseki
17. Tomokatsu Ikawa
18. Atsushi Iwama

• Curated by eLife

  eLife assessment

  The authors present a manuscript aiming to understand the mechanism(s) underlying myeloid bias in HSCs, specifically focused on the role of Pcgf1, and therefore PRC1.1, in the regulation of hematopoiesis. This important work is of interest to the community of researchers interested in myeloid differentiation, lineage fate decisions in hematopoietic stem cells, and the molecular mechanisms that contribute to the initiation of myeloid malignancies. The methods are rigorous and the results convincingly support the authors' conclusions.

Reviewed by eLife

Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy

1. Pedro P Cunha
2. Eleanor Minogue
3. Lena CM Krause
4. Rita M Hess
5. David Bargiela
6. Brennan J Wadsworth
7. Laura Barbieri
8. Carolin Brombach
9. Iosifina P Foskolou
10. Ivan Bogeski
11. Pedro Velica
12. Randall S Johnson

• Curated by eLife

  eLife assessment

  In the current manuscript, the authors study the effects of hypoxia or genetic and pharmacologic modulation of the hypoxic pathways on T cells. The findings about T cells sense hypoxia and how hypoxia affects T cell (and CAR T cell) differentiation and function are significant and interesting for the field. The data supporting these findings are mostly robust, yet some questions remain open and some statements seem unsupported by evidence.

Reviewed by eLife