Genomics

  1. Improving oligo-conjugated antibody signal in multimodal single-cell analysis

    1. Terkild B Buus
    2. Alberto Herrera
    3. Ellie Ivanova
    4. Eleni Mimitou
    5. Anthony Cheng
    6. Ramin S Herati
    7. Thales Papagiannakopoulos
    8. Peter Smibert
    9. Niels Odum
    10. Sergei B Koralov

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells

    1. Juan Carlos Jado
    2. Michelle Dow
    3. Krypton Carolino
    4. Adam Klie
    5. Gregory J. Fonseca
    6. Trey Ideker
    7. Hannah Carter
    8. Elizabeth A. Winzeler

    • Curated by eLife

      Summary: The authors examined the genomic basis of resistance evolution in human chronic myelogenous leukemia (CML) near-haploid cell lines to 5 separate chemotherapeutic agents.

      Using either whole genome or whole exome analysis, they found numerous instances of single nucleotide polymorphisms and copy number variants, including amplifications and deletions, among lines. They then used subsequent knockdown or knockout experiments to confirm that these variants, in fact, lead to increased resistance in these lines.

      The work is interesting, timely, and has potential clinical implications. For example, the resistance alleles identified here could be closely examined in future studies in order to develop treatment strategies. However, the experimental design has certain limitations, advances in understanding chemotherapy resistance mechanisms is currently modest, and the presentation of results can be improved. We feel overall that these could be addressed, but that they will require significant extra experimental work.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes

    1. Andrew D Skol
    2. Segun C Jung
    3. Ana Marija Sokovic
    4. Siquan Chen
    5. Sarah Fazal
    6. Olukayode Sosina
    7. Poulami P Borkar
    8. Amy Lin
    9. Maria Sverdlov
    10. Dingcai Cao
    11. Anand Swaroop
    12. Ionut Bebu
    13. DCCT/EDIC Study group
    14. Barbara E Stranger
    15. Michael A Grassi

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Gene expression variability in human and chimpanzee populations share common determinants

    1. Benjamin Jung Fair
    2. Lauren E Blake
    3. Abhishek Sarkar
    4. Bryan J Pavlovic
    5. Claudia Cuevas
    6. Yoav Gilad

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia

    1. Eilis Hannon
    2. Emma L Dempster
    3. Georgina Mansell
    4. Joe Burrage
    5. Nick Bass
    6. Marc M Bohlken
    7. Aiden Corvin
    8. Charles J Curtis
    9. David Dempster
    10. Marta Di Forta
    11. Timothy G Dinan
    12. Gary Donohoe
    13. Fiona Gaughran
    14. Michael Gill
    15. Amy Gillespie
    16. Cerisse Gunasinghe
    17. Hilleke E Hulshoff
    18. Christina M Hultman
    19. Viktoria Johansson
    20. Rene S Kahn
    21. Jaakko Kaprio
    22. Gunter Kenis
    23. Kaarina Kowalec
    24. James MacCabe
    25. Colm McDonald
    26. Andew McQuillin
    27. Derek W Morris
    28. Kieran C Murphy
    29. Collette Mustard
    30. Igor Nenadic
    31. Michael C O’Donovan
    32. Diego Quattrone
    33. Alexander L Richards
    34. Bart PF Rutten
    35. David St Clair
    36. Sebastian Therman
    37. Timothea Toulopoulou
    38. Jim Van Os
    39. John L Waddington
    40. Wellcome Trust Case Control Consortium 2
    41. CREeTable AR consortium
    42. Patrick Sullivan
    43. Evangelos Vassos
    44. Gerome Breen
    45. David Andrew Collier
    46. Robin Murray
    47. Leonard S Schalkwyk
    48. Jonathan Mill

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

    1. Jun Yao
    2. Douglas C Wu
    3. Ryan M Nottingham
    4. Alan M Lambowitz

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  7. Insights on early mutational events in SARS-CoV-2 virus reveal founder effects across geographical regions

    1. Carlos Farkas
    2. Francisco Fuentes-Villalobos
    3. Jose Luis Garrido
    4. Jody Haigh
    5. María Inés Barría

    Reviewed by ScreenIT, PeerJ

    4 evaluationsAppears in 2 listsLatest version Latest activity

  8. RdRp mutations are associated with SARS-CoV-2 genome evolution

    1. Doğa Eskier
    2. Gökhan Karakülah
    3. Aslı Suner
    4. Yavuz Oktay

    Reviewed by PeerJ, ScreenIT

    3 evaluationsAppears in 2 listsLatest version Latest activity

  9. Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    1. Lei Yang
    2. Michael Emerman
    3. Harmit S Malik
    4. Richard N McLaughlin

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Genomic features of parthenogenetic animals

    1. Kamil S. Jaron
    2. Jens Bast
    3. Reuben W. Nowell
    4. T. Rhyker Ranallo-Benavidez
    5. Marc Robinson-Rechavi
    6. Tanja Schwander

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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