Genomics

Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

1. Corbin SC Johnson
2. Carol A Shively
3. Kristofer T Michalson
4. Amanda J Lea
5. Ryne J DeBo
6. Timothy D Howard
7. Gregory A Hawkins
8. Susan E Appt
9. Yongmei Liu
10. Charles E McCall
11. David M Herrington
12. Edward H Ip
13. Thomas C Register
14. Noah Snyder-Mackler

• Curated by eLife

  Evaluation Summary:

  This is an interesting study aiming to link the evolutionary effects of dietary mismatch in humans to increased inflammatory responses and risk of chronic diseases. To uncover more insights into the causal links, the study used a non-human primate (macaque) model to show that the dietary switch from a Mediterranean to a modern Western diet leads to the polarisation of monocyte cell populations toward a more pro-inflammatory state, which in addition to increasing the chronic health risk can also impose behavioural changes such as anxiety and social isolation. The results of this study are convincing, interesting, and have fundamental importance in evolutionary biology, immunology and psychology. The extent to which these findings can be extrapolated to human populations remains to be established.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Unsupervised classification of SARS-CoV-2 genomic sequences uncovers hidden genetic diversity and suggests an efficient strategy for genomic surveillance

1. Matteo Chiara
2. David S. Horner
3. Erika Ferrandi
4. Carmela Gissi
5. Graziano Pesole

Reviewed by ScreenIT

Mapping the host protein interactome of non-coding regions in SARS-CoV-2 genome

1. Liuyiqi Jiang
2. Mu Xiao
3. Qing-Qing Liao
4. Luqian Zheng
5. Chunyan Li
6. Yuemei Liu
7. Bing Yang
8. Aiming Ren
9. Chao Jiang
10. Xin-Hua Feng

Reviewed by ScreenIT

Genetic diversity and evolution of SARS-CoV-2 in Belgium during the first wave outbreak

1. Tony Wawina-Bokalanga
2. Joan Martí-Carreras
3. Bert Vanmechelen
4. Mandy Bloemen
5. Elke Wollants
6. Lies Laenen
7. Lize Cuypers
8. Kurt Beuselinck
9. Katrien Lagrou
10. Emmanuel André
11. Marc Van Ranst
12. Piet Maes

Reviewed by ScreenIT

Predicting gene regulatory networks from multi-omics to link genetic risk variants and neuroimmunology to Alzheimer’s disease phenotypes

1. Saniya Khullar
2. Daifeng Wang

Reviewed by ScreenIT

Visual and Quantitative Analyses of Virus Genomic Sequences using a Metric-based Algorithm

1. Alexandra Belinsky
2. Guennadi A. Kouzaev

Reviewed by ScreenIT

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020—March 2021) Using a Statistical Learning Strategy

1. Lue Ping Zhao
2. Terry P. Lybrand
3. Peter B. Gilbert
4. Thomas R. Hawn
5. Joshua T. Schiffer
6. Leonidas Stamatatos
7. Thomas H. Payne
8. Lindsay N. Carpp
9. Daniel E. Geraghty
10. Keith R. Jerome

Reviewed by ScreenIT

Stepwise Evolution and Exceptional Conservation of ORF1a/b Overlap in Coronaviruses

1. Han Mei
2. Sergei Kosakovsky Pond
3. Anton Nekrutenko

Reviewed by ScreenIT

Identification of ACE2 modifiers by CRISPR screening

1. Emily J. Sherman
2. Carmen Mirabelli
3. Vi T. Tang
4. Taslima G. Khan
5. Andrew A. Kennedy
6. Sarah E. Graham
7. Cristen J. Willer
8. Andrew W. Tai
9. Jonathan Z. Sexton
10. Christiane E. Wobus
11. Brian T. Emmer

Reviewed by ScreenIT

Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome

1. Yu-Sheng Chen
2. Shuaiyao Lu
3. Bing Zhang
4. Tingfu Du
5. Wen-Jie Li
6. Meng Lei
7. Yanan Zhou
8. Yong Zhang
9. Penghui Liu
10. Yong-Qiao Sun
11. Yong-Liang Zhao
12. Ying Yang
13. Xiaozhong Peng
14. Yun-Gui Yang

Reviewed by ScreenIT