1. Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning

    This article has 6 authors:
    1. Gemma E May
    2. Christina Akirtava
    3. Matthew Agar-Johnson
    4. Jelena Micic
    5. John Woolford
    6. Joel McManus
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Protein abundance is the result of many layers of regulation, including at the levels of transcription, mRNA stability, translation and protein degradation. Many transcripts contain short upstream ORFs (uORFS), but their effects on the translation of the main ORFs are difficult to predict as they are sometimes negative, positive and of different magnitudes. Here, the authors identify features of uORFs using massively parallel reporter assays, and these features help predict uORF effects on translation of main ORFs. The results will be an important resource for the community of researchers using this model organism and for the molecular and cell biology community in general as they allow to better understand how genes are regulated. There are also areas in which the authors' claims or conclusions are not fully justified and require either additional statistical analysis or new experimentation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiation

    This article has 14 authors:
    1. Borja Gomez Ramos
    2. Jochen Ohnmacht
    3. Nikola de Lange
    4. Aurélien Ginolhac
    5. Elena Valceschini
    6. Aleksandar Rakovic
    7. Rashi Halder
    8. François Massart
    9. Christine Klein
    10. Roland Krause
    11. Marcel H. Schulz
    12. Thomas Sauter
    13. Rejko Krüger
    14. Lasse Sinkkonen

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. The Australasian dingo archetype: De novo chromosome-length genome assembly, DNA methylome, and cranial morphology

    This article has 16 authors:
    1. J. William O. Ballard
    2. Matt A. Field
    3. Richard J. Edwards
    4. Laura A.B. Wilson
    5. Loukas G. Koungoulos
    6. Benjamin D. Rosen
    7. Barry Chernoff
    8. Olga Dudchenko
    9. Arina Omer
    10. Jens Keilwagen
    11. Ksenia Skvortsova
    12. Ozren Bogdanovic
    13. Eva Chan
    14. Robert Zammit
    15. Vanessa Hayes
    16. Erez Lieberman Aiden

    Reviewed by GigaScience

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome

    This article has 5 authors:
    1. Yiwang Chen
    2. Qi Jiang
    3. Mijiti Peierdun
    4. Howard E Takiff
    5. Qian Gao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this useful study, a GWAS-type analysis is applied to clinical Mycobacterium tuberculosis isolates to discover genetic polymorphisms linked to poor tuberculosis outcomes. The evidence for the detected associations is still incomplete, as the corresponding polymorphisms are not adequate to power a prediction model for infection outcome, although key host factors - including patient age, sex, and duration of diagnostic delay (which have stronger predictive value) - appear to enhance predictive capacity.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Genome assembly of the deep-sea coral Lophelia pertusa

    This article has 2 authors:
    1. Santiago Herrera
    2. Erik E. Cordes

    Reviewed by GigaByte

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. The first genome assembly of the amphibian nematode parasite ( Aplectana chamaeleonis )

    This article has 4 authors:
    1. Lei Han
    2. Tianlu Liu
    3. Fengping He
    4. Zhijun Hou

    Reviewed by GigaByte

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Whole-genome sequencing of Chinese native goat offers biological insights into cashmere fiber formation

    This article has 21 authors:
    1. Hu Han
    2. Man-Man Yang
    3. Jiang Dan
    4. Xing-Ju Zhang
    5. Qiang Wei
    6. Tao Chen
    7. Qi-Ju Wang
    8. Cheng-Ye Yang
    9. Bater Wulan
    10. Ting-Ting Zhang
    11. Gang Gen
    12. Mengkedala
    13. Bin Li
    14. Wei-Dong Deng
    15. Ze-Pu Miao
    16. Ran Wang
    17. Qing-Feng Zhang
    18. Lin Li
    19. Sheng-Yu Chao
    20. Ming Fang
    21. Yong Li

    Reviewed by GigaScience

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

    This article has 11 authors:
    1. Benjamin Guinet
    2. David Lepetit
    3. Sylvain Charlat
    4. Peter N Buhl
    5. David G Notton
    6. Astrid Cruaud
    7. Jean-Yves Rasplus
    8. Julia Stigenberg
    9. Damien M de Vienne
    10. Bastien Boussau
    11. Julien Varaldi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important manuscript employs a rigorous and multi-pronged comparative genomics approach to unravel how lifestyle modulates the acquisition and domestication of viral genetic elements in the genomes of hymenopteran insects. Using an extensive dataset of over 120 hymenopteran genomes, the authors provide convincing evidence that endoparasitism (where parasite development occurs within hosts) facilitates the uptake and domestication of double-stranded DNA viral elements.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK

    This article has 15 authors:
    1. William Matlock
    2. Samuel Lipworth
    3. Kevin K Chau
    4. Manal AbuOun
    5. Leanne Barker
    6. James Kavanagh
    7. Monique Andersson
    8. Sarah Oakley
    9. Marcus Morgan
    10. Derrick W Crook
    11. Daniel S Read
    12. Muna Anjum
    13. Liam P Shaw
    14. Nicole Stoesser
    15. REHAB Consortium
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents valuable findings on the dissemination of plasmids. In an analysis of five major Enterobacterales genera, the authors convincingly demonstrate that similar plasmids are shared between genera, species, and clones, both within and between ecological niches. Given the size of the dataset and the very detailed level of analysis this study importantly contributes to insights into to the flow of plasmids, including those carrying antimicrobial resistance genes, across niches.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

    This article has 6 authors:
    1. Jeff Jiajing Zhou
    2. Jin Sun Cho
    3. Han Han
    4. Ira L Blitz
    5. Wenqi Wang
    6. Ken WY Cho
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this manuscript, the authors investigate the role of histone deacetylases in the spatial epigenetic control of zygotic gene expression in early gastrulation. They discover HDAC1 binding is maternally-controlled and that inhibition of histone acetylation blocks gastrulation and disrupts cell lineage integrity, tied to both positive and negative regulatory effects on gene transcription in space and time. The study contributes to a growing body of evidence that highlights a central role of histone acetylation-deacetylation dynamics in epigenetic regulation of gene expression and cell fating in early tissue patterning of the embryo.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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