Genomics

Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection

1. Wei Lin
2. Longfei Hu
3. Yan Zhang
4. Joshua D. Ooi
5. Ting Meng
6. Peng Jin
7. Xiang Ding
8. Longkai Peng
9. Lei Song
10. Zhou Xiao
11. Xiang Ao
12. Xiangcheng Xiao
13. Qiaoling Zhou
14. Ping Xiao
15. Jue Fan
16. Yong Zhong

Reviewed by ScreenIT

Exploring the coronavirus pandemic with the WashU Virus Genome Browser

1. Jennifer A. Flynn
2. Deepak Purushotham
3. Mayank N. K. Choudhary
4. Xiaoyu Zhuo
5. Changxu Fan
6. Gavriel Matt
7. Daofeng Li
8. Ting Wang

Reviewed by ScreenIT

Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection

1. Xiaoqiang Chai
2. Longfei Hu
3. Yan Zhang
4. Weiyu Han
5. Zhou Lu
6. Aiwu Ke
7. Jian Zhou
8. Guoming Shi
9. Nan Fang
10. Jia Fan
11. Jiabin Cai
12. Jue Fan
13. Fei Lan

Reviewed by ScreenIT

Alternative paths to immune activation: the role of costimulatory risk genes for polygenic inflammatory disease in T helper cells

1. Alexandru-Ioan Voda
2. Kristina Correa
3. Jonathan Hamp
4. Chloe Moscrop
5. Michael Dustin
6. Luke Jostins-Dean

• Curated by eLife

  eLife assessment

  This valuable study examines the effects of different co-stimulatory pathways on gene expression and chromatin accessibility in T cells, in order to link the role of co-stimulatory proteins to genetic variants associated with inflammatory bowl disease (IBD). The work provides valuable insight into the role of alternative co-stimulatory proteins in controlling T cell responses. However, the data presented and the analyses performed are still incomplete and inconclusive with regards to IBD risk factors.

Reviewed by eLife

Identification of a non-canonical ciliate nuclear genetic code where UAA and UAG code for different amino acids

1. Jamie McGowan
2. Estelle S. Kilias
3. Elisabet Alacid
4. James Lipscombe
5. Benjamin H. Jenkins
6. Karim Gharbi
7. Gemy G. Kaithakottil
8. Iain C. Macaulay
9. Seanna McTaggart
10. Sally D. Warring
11. Thomas A. Richards
12. Neil Hall
13. David Swarbreck

Reviewed by Review Commons

Massive genome reduction occurred prior to the origin of coral algal symbionts

1. Sarah Shah
2. Katherine E. Dougan
3. Yibi Chen
4. Rosalyn Lo
5. Gemma Laird
6. Michael D. A. Fortuin
7. Subash K. Rai
8. Valentine Murigneux
9. Anthony J. Bellantuono
10. Mauricio Rodriguez-Lanetty
11. Debashish Bhattacharya
12. Cheong Xin Chan

Reviewed by Arcadia Science

The Crown Pearl V2: an improved genome assembly of the European freshwater pearl mussel Margaritifera margaritifera (Linnaeus, 1758)

1. André Gomes-dos-Santos
2. Manuel Lopes-Lima
3. André M. Machado
4. Thomas Forest
5. Guillaume Achaz
6. Amílcar Teixeira
7. Vincent Prié
8. L. Filipe C. Castro
9. Elsa Froufe

• Curated by GigaByte

  Editor’s Assessment

  Like other mollusc species, the freshwater pearl mussel (Margaritifera margaritifera) has a challenging genome to assemble owing to the large size of their genomes, heterozygosity, and repetitive sequence. The first published M. margaritifera genome was highly fragmented, but here an improved reference genome assembly was generated using PacBio CLR long reads to reduce fragmentation levels, missing and truncated genes, and chimerically assembled regions. The number of gene models predicted is a bit higher compared than other molluscan genomes, but after clarification and double checking these seem in line with some Mollusca and Bivalvia with similar and higher numbers of gene predictions. This new genome represents a new resource to start exploring the many biological, ecological, and evolutionary features of this threatened and commercially important group of organisms.

  This assessment refers to version 1 of this preprint.

Reviewed by GigaByte

Annotating Metagenomically Assembled Bacteriophage from a Unique Ecological System using Protein Structure Prediction and Structure Homology Search

1. Henry Say
2. Ben Joris
3. Daniel Giguere
4. Gregory B. Gloor

Reviewed by Arcadia Science

Genome dynamics across the evolutionary transition to endosymbiosis

1. Stefanos Siozios
2. Pol Nadal Jimenez
3. Tal Azagi
4. Hein Sprong
5. Crystal L Frost
6. Steven R Parratt
7. Graeme Taylor
8. Laura Brettell
9. Kwee Chin Liew
10. Larry Croft
11. Kayla C King
12. Michael A Brockhurst
13. Václav Hypša
14. Eva Novakova
15. Alistair C Darby
16. Gregory DD Hurst

Reviewed by Arcadia Science

Histone variants shape chromatin states in Arabidopsis

1. Bhagyshree Jamge
2. Zdravko J Lorković
3. Elin Axelsson
4. Akihisa Osakabe
5. Vikas Shukla
6. Ramesh Yelagandula
7. Svetlana Akimcheva
8. Annika Luisa Kuehn
9. Frédéric Berger

• Curated by eLife

  eLife assessment

  This study presents an important description on the dynamics of histone variant exchange controlling the organization of the chromatin state of the Arabidopsis genome, combining the analysis of histone variants, histone modification, and chromatin states. The evidence supporting the claims of the authors is compelling. This work will be of great interest to those in the field of epigenetics and chromatin biology.

Reviewed by eLife