Genetics

Oligogenic heterozygous inheritance of sperm abnormalities in mouse

1. Guillaume Martinez
2. Charles Coutton
3. Corinne Loeuillet
4. Caroline Cazin
5. Jana Muroňová
6. Magalie Boguenet
7. Emeline Lambert
8. Magali Dhellemmes
9. Geneviève Chevalier
10. Jean-Pascal Hograindleur
11. Charline Vilpreux
12. Yasmine Neirijnck
13. Zine-Eddine Kherraf
14. Jessica Escoffier
15. Serge Nef
16. Pierre F Ray
17. Christophe Arnoult

• Curated by eLife

  Evaluation Summary:

  Oligogenic inheritance is likely to be an important mode of disease risk for many male infertility traits, but few validated examples exist. This clear documentation of oligogenic effects on mouse sperm is significant for both the sperm abnormality field and for the broader male infertility community.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Human Genetic Variants Associated with COVID-19 Severity are Enriched in Immune and Epithelium Regulatory Networks

1. Zhanying Feng
2. Xianwen Ren
3. Zhana Duren
4. Yong Wang

Reviewed by ScreenIT

History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure

1. Yuta Koganezawa
2. Miki Umetani
3. Moritoshi Sato
4. Yuichi Wakamoto

• Curated by eLife

  Evaluation Summary:

  This paper presents results showing the temporal relationships between deletion of a resistance gene, introduction of antibiotic, and cell growth that are intriguing and novel. It will be of interest to researchers studying heterogeneity in antibiotic tolerance and the origins of drug resistance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Functional profiling of long intergenic non-coding RNAs in fission yeast

1. Maria Rodriguez-Lopez
2. Shajahan Anver
3. Cristina Cotobal
4. Stephan Kamrad
5. Michal Malecki
6. Clara Correia-Melo
7. Mimoza Hoti
8. StJohn Townsend
9. Samuel Marguerat
10. Sheng Kai Pong
11. Mary Y Wu
12. Luis Montemayor
13. Michael Howell
14. Markus Ralser
15. Jürg Bähler

Reviewed by Review Commons

SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication

1. John Kee
2. Samuel Thudium
3. David Renner
4. Karl Glastad
5. Katherine Palozola
6. Zhen Zhang
7. Yize Li
8. Joseph Cesare
9. Yemin Lan
10. Rachel Truitt
11. Fabian L. Cardenas-Diaz
12. Darrell N. Kotton
13. Konstantinos D. Alysandratos
14. Xianwen Zhang
15. Xuping Xie
16. Pei-Yong Shi
17. Wenli Yang
18. Edward Morrisey
19. Benjamin A. Garcia
20. Shelley L. Berger
21. Susan R. Weiss
22. Erica Korb

Reviewed by ScreenIT

STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific super-enhancer in association with systemic lupus erythematosus

1. Yanfeng Zhang
2. Kenneth Day
3. Devin M Absher

• Curated by eLife

  Evaluation Summary:

  Zhang and colleagues have conduced extensive multi-omic data analyses and functional assays, aiming to identify novel risk variants and to then explore the potential mechanisms with which the identified variants mediate risk of systemic lupus erythematosus. The findings could advance the understanding of the genetic susceptibility and biology of systemic lupus erythematosus.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Mutating novel interaction sites in NRP1 reduces SARS-CoV-2 spike protein internalization

1. Debjani Pal
2. Kuntal De
3. Timothy B. Yates
4. Jaydeep Kolape
5. Wellington Muchero

Reviewed by ScreenIT

Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations

1. Rudra Kumar Pandey
2. Anshika Srivastava
3. Prajjval Pratap Singh
4. Gyaneshwer Chaubey

Reviewed by ScreenIT

Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing

1. Kärt Tomberg
2. Liliana Antunes
3. YangYang Pan
4. Jacob Hepkema
5. Dimitrios A. Garyfallos
6. Ahmed Mahfouz
7. Allan Bradley

Reviewed by ScreenIT

Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort

1. Xu Gao
2. Ninghao Huang
3. Xinbiao Guo
4. Tao Huang

Reviewed by ScreenIT