Genetics

Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

1. Laxmi Rathor
2. Shayla Curry
3. Youngyong Park
4. Taylor McElroy
5. Briana Robles
6. Yi Sheng
7. Wei-Wen Chen
8. Kisuk Min
9. Rui Xiao
10. Myon Hee Lee
11. Sung Min Han

• Curated by eLife

  eLife assessment

  This study interrogates cell non-autonomous signaling between GABAergic neurons and somatic tissues in the nematode C. elegans. The authors report that mitochondrial stress in only GABAergic neurons extends lifespan and improves healthspan, phenotypes that are dependent on the transcription factor daf-16/FOXO3a. However, while the findings may be valuable to furthering our understanding of neuronal control of aging and health, the current evidence is incomplete and additional experiments are needed to support their claims.

Reviewed by eLife

Functional dissection of complex trait variants at single-nucleotide resolution

1. Layla Siraj
2. Rodrigo I. Castro
3. Hannah B. Dewey
4. Susan Kales
5. John C. Butts
6. Thanh Thanh L. Nguyen
7. Masahiro Kanai
8. Daniel Berenzy
9. Kousuke Mouri
10. Qingbo S. Wang
11. Petko P. Fiziev
12. Kristin Tsuo
13. Zachary R. McCaw
14. Sager J. Gosai
15. François Aguet
16. Ran Cui
17. Irfahan Kassam
18. Jeremy McRae
19. Christopher M. Vockley
20. Caleb A. Lareau
21. Sergey Abramov
22. Alexandr Boystov
23. Jeff Vierstra
24. Yukinori Okada
25. Alexander Gusev
26. Thouis R. Jones
27. Eric S. Lander
28. Pardis C. Sabeti
29. Hilary K. Finucane
30. Steven K. Reilly
31. Jacob C. Ulirsch
32. Ryan Tewhey

Reviewed by Arcadia Science

The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

1. Nasim Saadat
2. Rhys N. Colson
3. Acadia L. Grimme
4. Uri Seroussi
5. Joshua W. Anderson
6. Julie M. Claycomb
7. Matthew C. J. Wilce
8. Katherine McJunkin
9. Jacqueline A. Wilce
10. Peter R. Boag

• Curated by eLife

  eLife assessment

  This useful study identifies amino acid residues in the C. elegans RNA-binding protein NHL-2 that are required for RNA binding in vitro and NHL-2 function in vivo. The evidence in support of the authors' mechanistic model is currently incomplete, as data implicating specific NHL-2 amino acids in RNA binding per se in vivo are not presented. This manuscript will be of interest to scientists working in the area of gene regulation.

Reviewed by eLife

Natural variation in infection specificity of Caenorhabditis briggsae isolates by two RNA viruses

1. Cigdem Alkan
2. Gautier Brésard
3. Lise Frézal
4. Aurélien Richaud
5. Albane Ruaud
6. Gaotian Zhang
7. Marie-Anne Félix

Reviewed by Review Commons

Lack of evidence supporting transgenerational effects of non-transmitted paternal alleles on the murine transcriptome

1. Rodrigo Gularte-Mérida
2. Carole Charlier
3. Michel Georges

• Curated by eLife

  eLife assessment

  This important article presents the results of a large screen for non-genetic transgenerational effects that may influence gene expression and other phenotypes in mice. An extraordinary amount of mouse breeding, phenotyping, and RNA sequencing data provide compelling evidence that, for the phenotypes and genomic regions interrogated in these mouse strains, non-genetic transgenerational effects of appreciable magnitude are likely to be extremely rare. This paper will be of broad interest to geneticists and of particular interest to those studying epigenetic inheritance.

Reviewed by eLife

Exploring functional conservation in silico : a new machine learning approach to RNA-editing

1. Michał Zawisza-Álvarez
2. Jesús Peñuela-Melero
3. Esteban Vegas
4. Ferran Reverter
5. Jordi Garcia-Fernàndez
6. Carlos Herrera-Úbeda

Reviewed by Review Commons