Genetic and Genomic Medicine

  1. Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B

    1. Özkan Aydemir
    2. Jeffrey A. Bailey
    3. Daniel Agardh
    4. Åke Lernmark
    5. Janelle A. Noble
    6. Agnes Andersson Svärd
    7. Elizabeth P. Blankenhorn
    8. Hemang Parikh
    9. Anette-G. Ziegler
    10. Jorma Toppari
    11. Beena Akolkar
    12. William A. Hagopian
    13. Marian J. Rewers
    14. John P. Mordes
    15. TEDDY Study Group

    • Curated by eLife

      eLife assessment

      This study presents valuable findings on genetic risk factors for type 1 diabetes and celiac disease using a large cohort from the Environmental Determinants of Diabetes in the Young (TEDDY) study. The evidence supporting the claims of the authors is solid, although the inclusion of the genetic effect of this locus on individuals with different genetic backgrounds would have strengthened the study. The work will be of interest to population geneticists working on diabetes and celiac disease.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. PYCR1 Levels Track with Premature and Chronological Skin Aging

    1. Kortessa Sotiropoulou
    2. Saniye Yumlu
    3. Tomoko Hirano
    4. Michael Maier
    5. Abigail Loh
    6. Peh Fern Ong
    7. Onn Siong Yim
    8. Chunping Liu
    9. Emmanuel Vial
    10. Umut Altunoğlu
    11. Sheela Nampoothiri
    12. Deepthi de Silva
    13. Björn Fischer-Zirnsak
    14. Hülya Kayserili
    15. Poh San Lai
    16. Oliver Dreesen
    17. Kenji Kabashima
    18. Uwe Kornak
    19. Nathalie Escande-Beillard
    20. Bruno Reversade

    • Curated by eLife

      eLife assessment

      This manuscript uses genetic mouse modeling to delve deeper into a rare human disease of aging. The targeted approaches employed lend greater pathophysiologic insight and makes this paper valuable to the field art large. Additionally, the approaches used are rigorous and solid in supporting their conclusions. Some minor weaknesses were noted along with suggestions to add greater clarity.

    Reviewed by eLife, preLights

    4 evaluationsAppears in 3 listsLatest version Latest activity

  3. Genetic associations for two biological age measures point to distinct aging phenotypes

    1. Chia‐Ling Kuo
    2. Luke C. Pilling
    3. Zuyun Liu
    4. Janice L. Atkins
    5. Morgan E. Levine

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. SARS-CoV-2 spread across the Colombian-Venezuelan border

    1. Alberto Paniz-Mondolfi
    2. Marina Muñoz
    3. Carolina Florez
    4. Sergio Gomez
    5. Angelica Rico
    6. Lisseth Pardo
    7. Esther C. Barros
    8. Carolina Hernández
    9. Lourdes Delgado
    10. Jesús E. Jaimes
    11. Luis Pérez
    12. Aníbal A. Teherán
    13. Hala Alejel Alshammary
    14. Ajay Obla
    15. Zenab Khan
    16. Jayeeta Dutta
    17. Adriana van de Guchte
    18. Ana S. Gonzalez-Reiche
    19. Matthew M. Hernandez
    20. Emilia Mia Sordillo
    21. Viviana Simon
    22. Harm van Bakel
    23. Martin S. Llewellyn
    24. Juan David Ramírez

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Polymorphisms in the ACE2 Locus Associate with Severity of COVID-19 Infection

    1. Luke Wooster
    2. Christopher J. Nicholson
    3. Haakon H. Sigurslid
    4. Christian L. Lino Cardenas
    5. Rajeev Malhotra

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection

    1. Miroslava Cuperlovic-Culf
    2. Emma L. Cunningham
    3. Hossen Teimoorinia
    4. Anuradha Surendra
    5. Xiaobei Pan
    6. Steffany A. L. Bennett
    7. Mijin Jung
    8. Bernadette McGuiness
    9. Anthony Peter Passmore
    10. David Beverland
    11. Brian D. Green

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients

    1. Krystyna Taylor
    2. Sayoni Das
    3. Matthew Pearson
    4. James Kozubek
    5. Marcin Pawlowski
    6. Claus Erik Jensen
    7. Zbigniew Skowron
    8. Gert Lykke Møller
    9. Mark Strivens
    10. Steve Gardner

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Analysis of Genomic Characteristics and Transmission Routes of Patients With Confirmed SARS-CoV-2 in Southern California During the Early Stage of the US COVID-19 Pandemic

    1. Wenjuan Zhang
    2. John Paul Govindavari
    3. Brian D. Davis
    4. Stephanie S. Chen
    5. Jong Taek Kim
    6. Jianbo Song
    7. Jean Lopategui
    8. Jasmine T. Plummer
    9. Eric Vail

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Evaluation of sample pooling for screening of SARS CoV-2

    1. Andargachew Mulu
    2. Dawit Hailu Alemayehu
    3. Fekadu Alemu
    4. Dessalegn Abeje Tefera
    5. Sinknesh Wolde
    6. Gebeyehu Aseffa
    7. Tamrayehu Seyoum
    8. Meseret Habtamu
    9. Alemseged Abdissa
    10. Abebe Genetu Bayih
    11. Getachew Tesfaye Beyene

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome

    1. Juan Gómez
    2. Guillermo M. Albaiceta
    3. Marta García-Clemente
    4. Carlos López-Larrea
    5. Laura Amado-Rodríguez
    6. Inés Lopez-Alonso
    7. Tamara Hermida
    8. Ana I. Enriquez
    9. Pablo Herrero
    10. Santiago Melón
    11. Marta E. Alvarez-Argüelles
    12. José A. Boga
    13. Susana Rojo-Alba
    14. Elías Cuesta-Llavona
    15. Victoria Alvarez
    16. Rebeca Lorca
    17. Eliecer Coto

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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