Developmental Biology

The mRNA decapping machinery targets LBD3/ASL9 to mediate apical hook and lateral root development in Arabidopsis

1. Zhangli Zuo
2. Milena Edna Roux
3. Jonathan Renaud Chevalier
4. Yasin F. Dagdas
5. Takafumi Yamashino
6. Søren Diers Højgaard
7. Emilie Knight
8. Lars Østergaard
9. Eleazar Rodriguez
10. Morten Petersen

Reviewed by Review Commons

Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease

1. Jos GA Smits
2. Dulce Lima Cunha
3. Maryam Amini
4. Marina Bertolin
5. Camille Laberthonnière
6. Jieqiong Qu
7. Nicholas Owen
8. Lorenz Latta
9. Berthold Seitz
10. Lauriane N Roux
11. Tanja Stachon
12. Stefano Ferrari
13. Mariya Moosajee
14. Daniel Aberdam
15. Nora Szentmary
16. Simon J. van Heeringen
17. Huiqing Zhou

Reviewed by Review Commons

Paracrine regulation of neural crest EMT by placodal MMP28

1. Nadège Gouignard
2. Anne Bibonne
3. João F. Mata
4. Fernanda Bajanca
5. Bianka Berki
6. Elias H. Barriga
7. Jean-Pierre Saint-Jeannet
8. Eric Theveneau

Reviewed by Review Commons

Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals

1. Zhipeng Wang
2. Cheng Jin
3. Pengyu Li
4. Yiran Li
5. Jielin Tang
6. Zhixin Yu
7. Tao Jiao
8. Jinhuan Ou
9. Han Wang
10. Dingfeng Zou
11. Mengzhen Li
12. Xinyu Mang
13. Jun Liu
14. Yan Lu
15. Kai Li
16. Ning Zhang
17. Jia Yu
18. Shiying Miao
19. Linfang Wang
20. Wei Song

• Curated by eLife

  eLife assessment

  This important study reports that Foxc2+ cells in the testis represent the quiescent spermatogonial stem cells (SSCs). The data supporting this claim are solid. The finding is of great significance to reproductive and stem-cell biology as male fertility depends on the fine balance between self-renewal and differentiation activities of the male germline stem cells, i.e., SSCs.

Reviewed by eLife

Kinetics of blood cell differentiation during hematopoiesis revealed by quantitative long-term live imaging

1. Kevin Yueh Lin Ho
2. Rosalyn Leigh Carr
3. Alexandra Dmitria Dvoskin
4. Guy Tanentzapf

• Curated by eLife

  eLife assessment

  This important study develops a new technical advancement in ex vivo live imaging of hematopoietic tissues to monitor blood cells in their native microenvironment. The new method for live imaging and tracking is compelling, and the strength and breadth of hematopoietic analysis are convincing. This work provides a very useful new system for immunologists and cell biologists, which will supply new perspectives on the system-level mechanisms of cell differentiation and innate immunity.

Reviewed by eLife

Three-dimensional imaging of vascular development in the mouse epididymis

1. Christelle Damon-Soubeyrand
2. Antonino Bongiovanni
3. Areski Chorfa
4. Chantal Goubely
5. Nelly Pirot
6. Luc Pardanaud
7. Laurence Piboin-Fragner
8. Caroline Vachias
9. Stephanie Bravard
10. Rachel Guiton
11. Jean-Leon Thomas
12. Fabrice Saez
13. Ayhan Kocer
14. Meryem Tardivel
15. Joël R Drevet
16. Joelle Henry-Berger

• Curated by eLife

  eLife assessment

  There are many strengths in this paper that examines patterns of epididymal blood and lymphatic vasculature, supported by quantitative methods, and well-conducted 3D imaging studies (graphics and videos). Minor weaknesses include the lack of higher magnification images and the organization of image panels in some figures. Overall, this is a very important contribution to the epididymis research field.

Reviewed by eLife

Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors

1. Dulama Richani
2. Anne Poljak
3. Baily Wang
4. Saabah B. Mahbub
5. Joanna Biazik
6. Jared M. Campbell
7. Abbas Habibalahi
8. William A. Stocker
9. Maria B. Marinova
10. Brett Nixon
11. Sonia Bustamante
12. David Skerrett-Byrne
13. Craig A. Harrison
14. Ewa Goldys
15. Robert B. Gilchrist

Reviewed by Review Commons

Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

1. Jaydeep Sidhaye
2. Philipp Trepte
3. Natalie Sepke
4. Maria Novatchkova
5. Michael Schutzbier
6. Gerhard Dürnberger
7. Karl Mechtler
8. Jürgen A Knoblich

• Curated by eLife

  eLife assessment

  The study integrates proteomic and transcriptomic analyses of human stem cell-derived cortical brain organoids, uncovering posttranscriptional regulatory mechanisms for a specific gene module enriched in ribosomal genes. The data analysis is robust and the evidence supporting the conclusions is compelling. The work provides a valuable resource to developmental neurobiologists and highlights a new level of regulation that may be important in cortical development.

Reviewed by eLife

Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

1. Valeria Scagliotti
2. Maria Lillina Vignola
3. Thea Willis
4. Mark Howard
5. Eugenia Marinelli
6. Carles Gaston-Massuet
7. Cynthia Andoniadou
8. Marika Charalambous

• Curated by eLife

  eLife assessment

  This important study uses elegant in vivo experiments combined with expression data on an imprinted gene, Dlk1, to demonstrate its role in pituitary gland size in mice. The evidence supporting the claims of the authors is solid, although the inclusion of both sexes and a rescue model would have strengthened the study. The work will be of interest to developmental biologists working on the pituitary and hypothalamus.

Reviewed by eLife

Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells

1. Deepti Prasad
2. Katharina Illek
3. Friedericke Fischer
4. Katrin Holstein
5. Anne-Kathrin Classen

• Curated by eLife

  eLife assessment

  This is an interesting study investigating a mechanism for the elimination of aberrant cells from epithelial tissues dependent on the contractility of the interface between cells with different fates regulated by JNK activity. This work offers insights into robustness and error correction mechanisms that help understand cell-cell competition and the origin of tumors. The study should be relevant for cell, developmental and cancer biologists.

Reviewed by eLife