Developmental Biology

Mouse scalp development requires Rac1 and SRF for the maintenance of mechanosensing mesenchyme

1. Bharath H. Rathnakar
2. Alex Rackley
3. Hae Ryong Kwon
4. William L. Berry
5. Lorin E. Olson

Reviewed by Review Commons

Krüppel Regulates Cell Cycle Exit and Limits Adult Neurogenesis of Mushroom Body Neural Progenitors in Drosophila

1. Dongni Shao Chen
2. Jin Man
3. Xian Shu
4. Haoer Shi
5. Xue Xia
6. Yusanjiang Abula
7. Yuu Kimata

• Curated by eLife

  eLife Assessment

  This study provides important insights into the regulation of neuroblast lifespan and proliferation in the Drosophila mushroom body, identifying Krüppel (Kr) as a key transcription factor promoting timely termination of these neuroblasts by repressing Imp expression, and proposes an antagonistic role of Krüppel homolog 1 (Kr-h1), whose overexpression leads to prolonged mushroom body neuroblast proliferation and tumor-like expansion. The findings are impactful for researchers interested in temporal patterning and neural development, and the methods and data analysis are solid, however, the precise regulatory interactions between Kr and Kr-h1 and their modes of action remain incompletely tested. Further experiments would be required to fully elucidate the mechanistic interplay between the factors involved.

Reviewed by eLife

Different cellular and molecular mechanisms of chitin deposition contribute to the specificity of the two chitin synthases in D. melanogaster

1. Joan Bertran-Mas
2. Ettore De Giorgio
3. Nicolás Martín
4. Marta Llimargas

Reviewed by Review Commons

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

1. Soomin Cho
2. Emilia Servián-Morilla
3. Victoria Navarro Garrido
4. Beatriz Rodriguez-Gonzalez
5. Youxi Yuan
6. Raquel Cano
7. Arjun A. Rambhiya
8. Radbod Darabi
9. Robert S. Haltiwanger
10. Carmen Paradas
11. Hamed Jafar-Nejad

Reviewed by Review Commons