Cardiovascular Medicine

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: a safety study

1. Gansheng Tan
2. Anna L Huguenard
3. Kara M Donovan
4. Phillip Demarest
5. Xiaoxuan Liu
6. Ziwei Li
7. Markus Adamek
8. Kory Lavine
9. Ananth K Vellimana
10. Terrance T Kummer
11. Joshua W Osbun
12. Gregory J Zipfel
13. Peter Brunner
14. Eric C Leuthardt

• Curated by eLife

  eLife assessment

  This study evaluated the role of transcutaneous auricular vagal nerve stimulation (taVNS) in patients with subarachnoid hemorrhage (SAH) randomized to taVNS vs sham, finding that those with active taVNS exhibited increased parasympathetic activity. The findings are important and cross-disciplinary, while the level of evidence is solid.

Reviewed by eLife

Associations of age at diagnosis of breast cancer with incident myocardial infarction and heart failure: A prospective cohort study

1. Jie Liang
2. Yang Pan
3. Wenya Zhang
4. Darui Gao
5. Yongqian Wang
6. Wuxiang Xie
7. Fanfan Zheng

• Curated by eLife

  eLife assessment

  In this valuable study, the authors sought to investigate the associations of age at breast cancer onset with the incidence of myocardial infarction and heart failure. Based on results from a series of compelling statistical analyses, the authors conclude that a younger onset age of breast cancer is associated with myocardial infarction and heart failure, highlighting the need to carefully monitor the cardiovascular status of women who have been diagnosed with breast cancer.

Reviewed by eLife

Derivation and Internal Validation of Prediction Models for Pulmonary Hypertension Risk Assessment in a Cohort Inhabiting Tibet, China

1. Junhui Tang
2. Rui Yang
3. Hui Li
4. Xiaodong Wei
5. Zhen Yang
6. Wenbin Cai
7. Yao Jiang
8. Ga Zhuo
9. Li Meng
10. Yali Xu

• Curated by eLife

  eLife assessment

  This study retrospectively analyzed clinical data to develop a risk prediction model for pulmonary hypertension in high-altitude populations. The evidence is solid and the findings are useful and hold clinical significance as the model can be used for intuitive and individualized prediction of pulmonary hypertension risk in these populations.

Reviewed by eLife

Evaluation of Clonal Hematopoiesis and Mosaic Loss of Y Chromosome in Cardiovascular Risk: an analysis in prospective studies

1. S Fawaz
2. S Marti
3. M Dufossée
4. Y Pucheu
5. A Gaufroy
6. J Broitman
7. A Bidet
8. A Soumaré
9. G Munsch
10. C Tzourio
11. S Debette
12. DA Trégouët
13. C James
14. O Mansier
15. T Couffinhal

• Curated by eLife

  eLife assessment

  In this small-scale study, Fawaz et al. report a significant prevalence of somatic mutations such as Clonal Hematopoiesis of Indeterminate Potential (CHIP) and mosaic loss of Y chromosome (mLOY), but lack of their association with a history of myocardial infarction (MI). The study utilized sensitive techniques, including targeted high-throughput sequencing and digital PCR. The valuable findings by the authors present a contrast to earlier reports, yet they align somewhat with some studies that have demonstrated little or no link between clonal hematopoiesis and atherothrombotic events. Although the study offers convincing results, its limited sample size and brief follow-up period preclude drawing definitive conclusions.

Reviewed by eLife

Identification of EPHB4 variants in dilated cardiomyopathy patients

1. Guillermo Luxán
2. Marion Muhly-Reinholz
3. Simone F. Glaser
4. Johannes Trebing
5. Christoph Reich
6. Jan Haas
7. Farbod Sedaghat-Hamedani
8. Benjamin Meder
9. Stefanie Dimmeler

Reviewed by Review Commons

Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins

1. Yingnan Zhang
2. Kelly Zhang
3. Adityo Prakosa
4. Cynthia James
5. Stefan L Zimmerman
6. Richard Carrick
7. Eric Sung
8. Alessio Gasperetti
9. Crystal Tichnell
10. Brittney Murray
11. Hugh Calkins
12. Natalia A Trayanova

• Curated by eLife

  eLife assessment

  This important study brings together a clear application of the digital twin approach to make predictions using patient specific models with different genotypes. The data are compelling and go beyond the current state-of-the-art to support proof-of-principle evidence. Given the low subject numbers, further studies will be required going forward to support the veracity of the data and its translational utility.

Reviewed by eLife

Early Diagnosis and Clinical Significance of Acute Cardiac Injury - Under the Iceberg: A Retrospective Cohort Study of 619 Non-critically Ill Hospitalized COVID-19 Pneumonia Patients

1. Yang Xie
2. Sichun Chen
3. Xueli Wang
4. Baige Li
5. Tianlu Zhang
6. Xingwei He
7. Ningling Sun
8. Luyan Wang
9. Hesong Zeng
10. Yin Shen

Reviewed by ScreenIT

Impact of congestive heart failure and role of cardiac biomarkers in COVID-19 patients: A systematic review and meta-analysis

1. Tarun Dalia
2. Shubham Lahan
3. Sagar Ranka
4. Prakash Acharya
5. Archana Gautam
6. Amandeep Goyal
7. Ioannis Mastoris
8. Andrew Sauer
9. Zubair Shah

Reviewed by ScreenIT

Excess of cardiovascular deaths during the COVID-19 pandemic in Brazilian capital cities

1. Luisa Campos Caldeira Brant
2. Bruno Ramos Nascimento
3. Renato Azeredo Teixeira
4. Marcelo Antônio Cartaxo Queiroga Lopes
5. Deborah Carvalho Malta
6. Glaucia Maria Moraes Oliveira
7. Antonio Luiz Pinho Ribeiro

Reviewed by ScreenIT

Chloroquine, but not hydroxychlorquine, prolongs the QT interval in a primary care population

1. Jonas L. Isaksen
2. Anders G. Holst
3. Adrian Pietersen
4. Jonas B. Nielsen
5. Claus Graff
6. Jørgen K. Kanters

Reviewed by ScreenIT