Cancer Biology

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

1. Deborah Fanfone
2. Zhichong Wu
3. Jade Mammi
4. Kevin Berthenet
5. David Neves
6. Kathrin Weber
7. Andrea Halaburkova
8. François Virard
9. Félix Bunel
10. Catherine Jamard
11. Hector Hernandez-Vargas
12. Stephen WG Tait
13. Ana Hennino
14. Gabriel Ichim

• Curated by eLife

  Evaluation Summary:

  The study proposes that confined migration renders breast cancer cells resistant to apoptosis via NFkappaB-dependent mechanisms. The technical aspects of the study are impressive and experiments are very well performed and demonstrate the value of mimetic bioengineering approaches, but the postulated central premise would require more rigorous support.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

1. Shreoshi Sengupta
2. Mainak Mondal
3. Kaval Reddy Prasasvi
4. Arani Mukherjee
5. Prerna Magod
6. Serge Urbach
7. Dinorah Friedmann-Morvinski
8. Philippe Marin
9. Kumaravel Somasundaram

• Curated by eLife

  Evaluation Summary:

  The authors shed light on the role that non-cancer stem cell exerts in promoting cancer progression, revealing that non-cancer stem cell-secreted fibromodulin is crucial in mediating angiogenesis in glioma via integrin-dependent Notch signaling. The logic is smooth and clear and the results are solid, and the findings should be interesting for those who are expertized in the field of cancer biology and cancer stem cell.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

1. Ngoc Lan Tran
2. Lorena Maria Ferreira
3. Blanca Alvarez-Moya
4. Valentina Buttiglione
5. Barbara Ferrini
6. Paola Zordan
7. Andrea Monestiroli
8. Claudio Fagioli
9. Eugenia Bezzecchi
10. Giulia Maria Scotti
11. Antonio Esposito
12. Riccardo Leone
13. Chiara Gnasso
14. Andrea Brendolan
15. Luca G Guidotti
16. Giovanni Sitia

Reviewed by Review Commons

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

1. James Boot
2. Gabriel Rosser
3. Dailya Kancheva
4. Claire Vinel
5. Yau Mun Lim
6. Nicola Pomella
7. Xinyu Zhang
8. Loredana Guglielmi
9. Denise Sheer
10. Michael Barnes
11. Sebastian Brandner
12. Sven Nelander
13. Kiavash Movahedi
14. Silvia Marino

• Curated by eLife

  Evaluation Summary:

  Glioblastoma is a challenging disease with a high level of heterogeneity. Here the authors use global methylation profiling of tumor-initiating cells and matched iNSCs and identify a subgroup of hypomethylated tumors with an astrocytic phenotype. Understanding heterogeneity in glioblastoma is a major challenge, and the identification of alterations of functional and clinical impact is of importance to the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple‐negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

1. Yunting Jian
2. Lingzhi Kong
3. Hongyi Xu
4. Yawei Shi
5. Xinjian Huang
6. Wenjing Zhong
7. Shumei Huang
8. Yue Li
9. Dongni Shi
10. Yunyun Xiao
11. Muwen Yang
12. Siqi Li
13. Xiangfu Chen
14. Ying Ouyang
15. Yameng Hu
16. Xin Chen
17. Libing Song
18. Runyi Ye
19. Weidong Wei

• Curated by eLife

  Evaluation Summary:

  The manuscript presents data that high expression of Protein Phosphatase 1 (PP1) inhibitor in triple-negative breast cancer contributes to poor outcomes by downregulation of an important kinase, GSK3β. The study clearly demonstrates that changes in PPP1R14C expression alter the behaviour of the studied cancer cells and mouse models and proposes a mechanism linking PP1 inhibitor to GSK3β. If this mechanism were substantiated, this would enhance our understanding of the pathophysiology of this important disease and might suggest new treatment options.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis

1. Limin Jiang
2. Hui Yu
3. Scott Ness
4. Peng Mao
5. Fei Guo
6. Jijun Tang
7. Yan Guo

• Curated by eLife

  Evaluation Summary:

  This paper provides a comprehensive co-mutation analysis of over 30 thousand cancer patients and 1700+ cancer cell lines to identify associations with prognosis and drug resistance that could have translational value for clinical practice. Once validated, it would provide a useful framework for precision oncology.

  “(This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.”.)

Reviewed by eLife

Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

1. Laura M Doherty
2. Caitlin E Mills
3. Sarah A Boswell
4. Xiaoxi Liu
5. Charles Tapley Hoyt
6. Benjamin Gyori
7. Sara J Buhrlage
8. Peter K Sorger

• Curated by eLife

  Evaluation Summary:

  To better understand proteins and pathways regulated by deubiquitinating enzymes (DUBs), this study has assembled a database that integrates existing datasets with additional knock-out experiments. Co-dependent genes as well as protein-protein interactions and co-expression were taken into account. The combined data confirms known functions and highlights potential new functions of DUBs. This will be a useful resource for investigators aiming to elucidate DUB functions, as well as for research efforts to develop therapies for the treatment of different cancer types through targeting DUBs.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

1. Stefania Monterisi
2. Johanna Michl
3. Alzbeta Hulikova
4. Jana Koth
5. Esther M Bridges
6. Amaryllis E Hill
7. Gulnar Abdullayeva
8. Walter F Bodmer
9. Pawel Swietach

• Curated by eLife

  Evaluation Summary:

  This work shows that spontaneous mutations in cancer cells affecting metabolic pathways do not necessarily result in functional defects, as affected cells may be able to be rescued by gap junction-mediated exchange of metabolites. This is verified in three specific examples, although some of the "quantitative" methods of measuring gap junctional coupling are actually only qualitative in nature. In addition, more experiments are needed to address the effect of Cx31 and Cx43 KD. This paper is of potential interest to a broad readership in cancer biology as well as colleagues studying metabolic pathways.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The network of SARS-CoV-2—cancer molecular interactions and pathways

1. Pau Erola
2. Richard M. Martin
3. Tom R. Gaunt

Reviewed by ScreenIT

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation

1. Mark Borris D. Aldonza
2. Junghwa Cha
3. Insung Yong
4. Jayoung Ku
5. Dabin Lee
6. Pavel Sinitcyn
7. Ryeong-Eun Cho
8. Roben D. Delos Reyes
9. Dongwook Kim
10. Hye-Jin Sung
11. Soyeon Kim
12. Minjeong Kang
13. Yongsuk Ku
14. Geonho Park
15. Han Suk Ryu
16. Sukki Cho
17. Tae Min Kim
18. Pilnam Kim
19. Je-Yoel Cho
20. Yoosik Kim

• Curated by eLife

  Evaluation Summary:

  This manuscript provides a comprehensive unbiased analysis of the fucosylation secretome and correlates with drug response in cancer. It uses a combination of bioinformatic based analyses of multiple datasets and cell based data to identify changes in the secretome and correlates this to drug responses to several targeted therapies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife