Biophysics

MMGB/SA Consensus Estimate of the Binding Free Energy Between the Novel Coronavirus Spike Protein to the Human ACE2 Receptor

1. Negin Forouzesh
2. Alexey V. Onufriev

Reviewed by ScreenIT

Machine Learning Reveals the Critical Interactions for SARS-CoV-2 Spike Protein Binding to ACE2

1. Anna Pavlova
2. Zijian Zhang
3. Atanu Acharya
4. Diane L. Lynch
5. Yui Tik Pang
6. Zhongyu Mou
7. Jerry M. Parks
8. Chris Chipot
9. James C. Gumbart

Reviewed by ScreenIT

Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complex

1. Shun Sakuraba
2. Qilin Xie
3. Kota Kasahara
4. Junichi Iwakiri
5. Hidetoshi Kono

Reviewed by ScreenIT

A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

1. Barbara Storti
2. Paola Quaranta
3. Cristina Di Primio
4. Nicola Clementi
5. Nicasio Mancini
6. Elena Criscuolo
7. Pietro Giorgio Spezia
8. Vittoria Carnicelli
9. Giulia Lottini
10. Emanuele Paolini
11. Giulia Freer
12. Michele Lai
13. Mario Costa
14. Fabio Beltram
15. Alberto Diaspro
16. Mauro Pistello
17. Riccardo Zucchi
18. Paolo Bianchini
19. Giovanni Signore
20. Ranieri Bizzarri

Reviewed by ScreenIT

Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation

1. Slav A. Semerdzhiev
2. Mohammad A. A. Fakhree
3. Ine Segers-Nolten
4. Christian Blum
5. Mireille M. A. E. Claessens

Reviewed by ScreenIT

Theoretical causes of the Brazilian P.1 and P.2 lineages of the SARS-CoV-2 virus through molecular dynamics

1. Micael D. L. Oliveira
2. Kelson M. T. Oliveira
3. Jonathas N. Silva
4. Clarice Santos
5. João Bessa
6. Rosiane de Freitas

Reviewed by ScreenIT

A Modified ACE2 peptide mimic to block SARS-CoV2 entry

1. Suman Saurabh
2. Shubh Sanket Purohit

Reviewed by ScreenIT

Muscle-specific economy of force generation and efficiency of work production during human running

1. Sebastian Bohm
2. Falk Mersmann
3. Alessandro Santuz
4. Arno Schroll
5. Adamantios Arampatzis

• Curated by eLife

  Evaluation Summary:

  This paper is of interest to scientists within the field of motor control and biomechanics studying human locomotion. The work provides evidence for the optimization of muscle function during locomotion depending on the specific biomechanical constraints. The overall methodology is sound and data are properly analyzed, although the in vivo measurements required a complex experimental setup together with sophisticated modeling which on the one hand conclusively support the key claims of the paper for the experiment within this paper, on the other hand weakens the generalizability of the results.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

1. Pascal D Odermatt
2. Teemu P Miettinen
3. Joël Lemière
4. Joon Ho Kang
5. Emrah Bostan
6. Scott R Manalis
7. Kerwyn Casey Huang
8. Fred Chang

• Curated by eLife

  Evaluation Summary:

  This article contributes to the fundamental understanding of how a cell grows. It provides a broadly applicable method for dry mass measurement of single cells and, using it, it describe how cell density varies accross the cell division cycle. The key finding of this article is the fact that growth in mass and volume seem to be generally uncoupled, leading to significant density changes.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Ciliary chemosensitivity is enhanced by cilium geometry and motility

1. David Hickey
2. Andrej Vilfan
3. Ramin Golestanian

• Curated by eLife

  Evaluation Summary:

  The authors consider how the geometry and motility of cilia affect their performance in detecting chemicals in the surrounding fluid. Based on a theoretical model, the authors suggest that the distinctive elongated shape of a cilium may be coupled to its sensory function. The conjectures presented in this work are likely to be of interest to a wide readership, but whether this actually applies to real biological systems requires more careful validation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife