Biophysics

Biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivity

1. Ratul Chowdhury
2. Costas D. Maranas

Reviewed by ScreenIT

In-Silico evidence for two receptors based strategy of SARS-CoV-2

1. Edoardo Milanetti
2. Mattia Miotto
3. Lorenzo Di Rienzo
4. Michele Monti
5. Giorgio Gosti
6. Giancarlo Ruocco

Reviewed by ScreenIT

Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS-CoV-2 spike protein

1. Cecylia S. Lupala
2. Xuanxuan Li
3. Jian Lei
4. Hong Chen
5. Jianxun Qi
6. Haiguang Liu
7. Xiao-dong Su

Reviewed by ScreenIT

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

1. Zhe Li
2. Xin Li
3. Yi-You Huang
4. Yaoxing Wu
5. Runduo Liu
6. Lingli Zhou
7. Yuxi Lin
8. Deyan Wu
9. Lei Zhang
10. Hao Liu
11. Ximing Xu
12. Kunqian Yu
13. Yuxia Zhang
14. Jun Cui
15. Chang-Guo Zhan
16. Xin Wang
17. Hai-Bin Luo

Reviewed by ScreenIT

A Multiscale and Comparative Model for Receptor Binding of 2019 Novel Coronavirus and the Implication of its Life Cycle in Host Cells

1. Zhaoqian Su
2. Yinghao Wu

Reviewed by ScreenIT

Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor

1. Jun Lan
2. Jiwan Ge
3. Jinfang Yu
4. Sisi Shan
5. Huan Zhou
6. Shilong Fan
7. Qi Zhang
8. Xuanling Shi
9. Qisheng Wang
10. Linqi Zhang
11. Xinquan Wang

Reviewed by ScreenIT

Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

1. Robert N. Kirchdoerfer
2. Mahesh Bhandari
3. Olnita Martini
4. Leigh M. Sewall
5. Sandhya Bangaru
6. Kyoung-Jin Yoon
7. Andrew B. Ward

Reviewed by ScreenIT

Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host–microbe associations

1. Janna C Nawroth
2. Christoph Giez
3. Alexander Klimovich
4. Eva Kanso
5. Thomas CG Bosch

• Curated by eLife

  eLife assessment

  This important work studies the spontaneous contractions (SC) of the Hydra body wall and presents a mathematical model of nutrient transport to hypothesize the role of SC on maintaining the microbiota. The solid evidence presented yields insights on the functional implications of the SC and the increased nutrient update obtained from mixing the local fluid environment through body wall contractions. The main result represents an important observation about the role of hydrodynamics on organism behavior and its relation to diffusive chemical transport processes.

Reviewed by eLife

Agonist efficiency links binding and gating in a nicotinic receptor

1. Dinesh C Indurthi
2. Anthony Auerbach

• Curated by eLife

  eLife assessment

  This valuable work investigates the fundamental concept of how the energy of agonist binding is converted into the energy of the conformational change that opens the pore of a ligand-gated ion channel. The conclusions are based on analysis of solid data in terms of a mechanistic model, but adequate statistical analysis is lacking and the uniqueness of the proposed model is not discussed. The findings will be interesting to biophysicists working on ligand-gated ion channels and, more generally, to enzymologists focused on allosteric enzyme regulation.

Reviewed by eLife

EMT induces cell-cycle-dependent changes of Rho GTPases and downstream effectors

1. Kamran Hosseini
2. Annika Frenzel
3. Elisabeth Fischer-Friedrich

Reviewed by Arcadia Science