Bioinformatics

CIGB-300 synthetic peptide, an antagonist of CK2 kinase activity, as a treatment for Covid-19. A computational biology approach

1. Jamilet Miranda
2. Ricardo Bringas
3. Jorge Fernández-de-Cossio
4. Yasser Perera

Reviewed by ScreenIT

Evolutionary dynamics of indels in SARS-CoV-2 spike glycoprotein

1. R. Shyama Prasad Rao
2. Nagib Ahsan
3. Chunhui Xu
4. Lingtao Su
5. Jacob Verburgt
6. Luca Fornelli
7. Daisuke Kihara
8. Dong Xu

Reviewed by ScreenIT

A conditional gene-based association framework integrating isoform-level eQTL data reveals new susceptibility genes for schizophrenia

1. Xiangyi Li
2. Lin Jiang
3. Chao Xue
4. Mulin Jun Li
5. Miaoxin Li

• Curated by eLife

  Evaluation Summary:

  This manuscript describes an improved approach (MGCA) to identify risk genes for human traits and diseases using data from genome wide association studies. The authors demonstrate the utility of their approach by analyzing data from patients with schizophrenia, and narrow in meaningful biological processes and potential drug repurposing candidates. This approach will facilitate gene prioritization from large genetic datasets for downstream applications such as functional studies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SCRaPL: A Bayesian hierarchical framework for detecting technical associates in single cell multiomics data

1. Christos Maniatis
2. Catalina A. Vallejos
3. Guido Sanguinetti

Reviewed by Review Commons

CoVizu: Rapid analysis and visualization of the global diversity of SARS-CoV-2 genomes

1. Roux-Cil Ferreira
2. Emmanuel Wong
3. Gopi Gugan
4. Kaitlyn Wade
5. Molly Liu
6. Laura Muñoz Baena
7. Connor Chato
8. Bonnie Lu
9. Abayomi S Olabode
10. Art F Y Poon

Reviewed by ScreenIT

Lung Epithelial Regulation of BCL2 Related Protein A1 (BCL2A1) by Coronaviruses (SARS-CoV) and Type I Interferon Signaling

1. Chilakamarti V. Ramana

Reviewed by ScreenIT

Visualizing Amino Acid Substitutions in a Physicochemical Vector Space

1. Louis R. Nemzer

Reviewed by ScreenIT

Data-driven analysis of amino acid change dynamics timely reveals SARS-CoV-2 variant emergence

1. Anna Bernasconi
2. Lorenzo Mari
3. Renato Casagrandi
4. Stefano Ceri

Reviewed by ScreenIT

Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2

1. Adebiyi Sobitan
2. Vidhyanand Mahase
3. Raina Rhoades
4. Dejaun Williams
5. Dongxiao Liu
6. Yixin Xie
7. Lin Li
8. Qiyi Tang
9. Shaolei Teng

Reviewed by ScreenIT

Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica

1. Jose Arturo Molina-Mora

Reviewed by ScreenIT