Bioengineering

Humans optimally anticipate and compensate for an uneven step during walking

1. Osman Darici
2. Arthur D Kuo

• Curated by eLife

  Evaluation Summary:

  This study provides experimental evidence supporting an energy optimality principle for walking over uneven terrain. Using a simple rimless wheel model of human walking, the authors previously predicted speed fluctuations to emerge when a step up or down when energy is minimized over the entire walking path. New experimental evidence provides evidence that both anticipatory and reactive adjustments used by the nervous system follow the predictions of an energy minimization principle. The predictive power of an energy-minimization principle during transient, non-steady state behavior is notable. Certain issues regarding the generalizability of the results to variable step lengths and timing, alternative optimality criteria, and limitations of the modeling assumptions should be clarified.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife, preLights

Antibody Display of cell surface receptor Tetraspanin12 and SARS-CoV-2 spike protein

1. Fu-Lien Hsieh
2. Tao-Hsin Chang

Reviewed by ScreenIT

Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

1. Fangzhu Zhao
2. Meng Yuan
3. Celina Keating
4. Namir Shaabani
5. Oliver Limbo
6. Collin Joyce
7. Jordan Woehl
8. Shawn Barman
9. Alison Burns
10. Quoc Tran
11. Xueyong Zhu
12. Michael Ricciardi
13. Linghang Peng
14. Jessica Smith
15. Deli Huang
16. Bryan Briney
17. Devin Sok
18. David Nemazee
19. John R. Teijaro
20. Ian A. Wilson
21. Dennis R. Burton
22. Joseph G. Jardine

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Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

1. Laura T. Gray
2. Michal M. Raczy
3. Priscilla S. Briquez
4. Tiffany M. Marchell
5. Aaron T. Alpar
6. Rachel P. Wallace
7. Lisa R. Volpatti
8. Maria Stella Sasso
9. Shijie Cao
10. Mindy Nguyen
11. Aslan Mansurov
12. Erica Budina
13. Elyse A. Watkins
14. Ani Solanki
15. Nikolaos Mitrousis
16. Joseph W. Reda
17. Shann S. Yu
18. Andrew C. Tremain
19. Ruyi Wang
20. Vlad Nicolaescu
21. Kevin Furlong
22. Steve Dvorkin
23. Balaji Manicassamy
24. Glenn Randall
25. D. Scott Wilson
26. Marcin Kwissa
27. Melody A. Swartz
28. Jeffrey A. Hubbell

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High level production and characterization of truncated human angiotensin converting enzyme 2 in Nicotiana benthamiana plant as a potential therapeutic target in COVID-19

1. Tarlan Mamedov
2. İrem Gürbüzaslan
3. Merve Ilgin
4. Damla Yuksel
5. Gunay Mammadova
6. Aykut Ozkul
7. Gulnara Hasanova

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Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip System

1. Min Zhang
2. Peng Wang
3. Ronghua Luo
4. Yaqing Wang
5. Zhongyu Li
6. Yaqiong Guo
7. Yulin Yao
8. Minghua Li
9. Tingting Tao
10. Wenwen Chen
11. Jianbao Han
12. Haitao Liu
13. Kangli Cui
14. Xu Zhang
15. Yongtang Zheng
16. Jianhua Qin

Reviewed by ScreenIT

Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

1. Miguel Martí
2. Alberto Tuñón-Molina
3. Finn Aachmann
4. Yukiko Muramoto
5. Takeshi Noda
6. Kazuo Takayama
7. Ángel Serrano-Aroca

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Modeling SARS-CoV-2 infection in vitro with a human intestine-on-chip device

1. Yaqiong Guo
2. Ronghua Luo
3. Yaqing Wang
4. Pengwei Deng
5. Min Zhang
6. Peng Wang
7. Xu Zhang
8. Kangli Cui
9. Tingting Tao
10. Zhongyu Li
11. Wenwen Chen
12. Yongtang Zheng
13. Jianhua Qin

Reviewed by ScreenIT

RAPPID: a platform of ratiometric bioluminescent sensors for homogeneous immunoassays

1. Yan Ni
2. Bas J.H.M. Rosier
3. Eva A. van Aalen
4. Eva T.L. Hanckmann
5. Lieuwe Biewenga
6. Anna-Maria Makri Pistikou
7. Bart Timmermans
8. Chris Vu
9. Sophie Roos
10. Remco Arts
11. Wentao Li
12. Tom F.A. de Greef
13. Frank J. M. van Kuppeveld
14. Berend-Jan Bosch
15. Maarten Merkx

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Intranasal administration of SARS-CoV-2 neutralizing human antibody prevents infection in mice

1. Hongbing Zhang
2. Zhiyuan Yang
3. Jingyi Xiang
4. Ziyou Cui
5. Jianying Liu
6. Cheng Liu

Reviewed by ScreenIT