Biochemistry

Torsion angles to map and visualize the conformational space of a protein

1. Helen Mary Ginn

Reviewed by PREreview

Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

1. Christopher H Emfinger
2. Lauren E Clark
3. Brian Yandell
4. Kathryn L Schueler
5. Shane P Simonett
6. Donnie S Stapleton
7. Kelly A Mitok
8. Matthew J Merrins
9. Mark P Keller
10. Alan D Attie

• Curated by eLife

  eLife assessment

  The authors provide a fundamental resource, detailing genetic variation of nutrient-responsive islet calcium regulation in mice through the lens of proteomics. The evidence for the mechanisms identified using this resource is compelling and strongly supported by integration with results from genome-wide association studies in humans. The construction of a streamlined and searchable web interface for the data will maximize their accessibility and utilization by the community.

Reviewed by eLife

Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy

1. Haoyan Huang
2. Meng Qian
3. Yue Liu
4. Shang Chen
5. Huifang Li
6. Zhibo Han
7. Zhong-Chao Han
8. Xiang-Mei Chen
9. Qiang Zhao
10. Zongjin Li

• Curated by eLife

  eLife assessment

  This important study combines engineered mesenchymal stem cells together with mouse models of kidney injury to determine the ability of these cells to reduce kidney damage upon acute kidney injury. The evidence supporting the claims is solid, although the inclusion of more than one type of stem cell and the use of male mice which are more prone to acute kidney injury, would strengthen the study. This work will be of interest to both basic scientists and clinicians working on mechanisms of kidney injury and repair.

Reviewed by eLife

The adherens junction proteins α-catenin, vinculin and VASP cooperate to promote actin assembly

1. Rayan Said
2. Hong Wang
3. Julien Pernier
4. Hemalatha Narassimprakash
5. Stéphane Roméro
6. Alexis M. Gautreau
7. René-Marc Mège
8. Christophe Le Clainche

Reviewed by Arcadia Science

The structural basis of itch receptor MRGPRX1 activation

1. Bing Gan
2. Leiye Yu
3. Haifeng Yang
4. Haizhan Jiao
5. Bin Pang
6. Yian Chen
7. Chen Wang
8. Rui Lv
9. Hongli Hu
10. Zhijian Cao
11. Ruobing Ren

Reviewed by Arcadia Science

Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities

1. Sabrina Ninck
2. Thomas Klaus
3. Tatiana V. Kochetkova
4. Sarah P. Esser
5. Leonard Sewald
6. Farnusch Kaschani
7. Christopher Bräsen
8. Alexander J. Probst
9. Ilya V. Kublanov
10. Bettina Siebers
11. Markus Kaiser

Reviewed by Arcadia Science

McrD binds asymmetrically to methyl-coenzyme M reductase improving active-site accessibility during assembly

1. Grayson L. Chadwick
2. Aaron M. N. Joiner
3. Sangeetha Ramesh
4. Douglas A. Mitchell
5. Dipti D. Nayak

Reviewed by Arcadia Science

Chemical factors induce aggregative multicellularity in a close unicellular relative of animals

1. Núria Ros-Rocher
2. Ria Q. Kidner
3. Catherine Gerdt
4. W. Sean Davidson
5. Iñaki Ruiz-Trillo
6. Joseph P. Gerdt

Reviewed by Arcadia Science

The mechanism of Atg15-mediated membrane disruption in autophagy

1. Yoko Kagohashi
2. Michiko Sasaki
3. Alexander I. May
4. Tomoko Kawamata
5. Yoshinori Ohsumi

Reviewed by Review Commons

Mechanistic insights into GTP-dependence and kinetic polarity of FtsZ filament assembly

1. Joyeeta Chakraborty
2. Sakshi Poddar
3. Soumyajit Dutta
4. Vaishnavi Bahulekar
5. Shrikant Harne
6. Ramanujam Srinivasan
7. Pananghat Gayathri

Reviewed by Review Commons