Allergy and Immunology

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

1. Marianna Santopaolo
2. Michaela Gregorova
3. Fergus Hamilton
4. David Arnold
5. Anna Long
6. Aurora Lacey
7. Elizabeth Oliver
8. Alice Halliday
9. Holly Baum
10. Kristy Hamilton
11. Rachel Milligan
12. Olivia Pearce
13. Lea Knezevic
14. Begonia Morales Aza
15. Alice Milne
16. Emily Milodowski
17. Eben Jones
18. Rajeka Lazarus
19. Anu Goenka
20. Adam Finn
21. Nicholas Maskell
22. Andrew D Davidson
23. Kathleen Gillespie
24. Linda Wooldridge
25. Laura Rivino

• Curated by eLife

  eLife assessment

  This valuable paper uses a cohort of SARS-CoV-2 infected people to link immune signatures 3 months post-infection with persistent, long COVID-19 symptoms. The strength of the evidence presented is solid based on a wide array of immunologic assays and a strategically designed cohort, with some claims that are incomplete based on a lack of specifically designed endpoints, lack of analysis of regulatory signals, and incomplete use of control samples. A couple of findings are novel and will be of interest to clinicians and immunologists, particularly that degree of inflammation at 3 months does not impair the generation of SARS-CoV-2 humoral and cellular memory responses and that cellular immune signatures are only somewhat correlated with long COVID-19 symptoms.

Reviewed by eLife

Human influenza virus infection elicits distinct patterns of monocyte and dendritic cell mobilization in blood and the nasopharynx

1. Sindhu Vangeti
2. Sara Falck-Jones
3. Meng Yu
4. Björn Österberg
5. Sang Liu
6. Muhammad Asghar
7. Klara Sondén
8. Clare Paterson
9. Penn Whitley
10. Jan Albert
11. Niclas Johansson
12. Anna Färnert
13. Anna Smed-Sörensen

• Curated by eLife

  eLife assessment

  This study presents a careful evaluation of the distribution of monocytes and dendritic cells in the the blood and nasopharyngeal aspirates of patients with mild respiratory tract infections. There are some interesting differences between monocytes and dendritic cells and variations with patient age. This is an important contribution to understanding monocyte and DC subset specific functions in dependency on the tissue microenvironment.

Reviewed by eLife

CMV seropositivity in older adults changes the T cell repertoire, but does not prevent antibody or cellular responses to SARS-CoV-2 vaccination

1. Jessica A. Breznik
2. Angela Huynh
3. Ali Zhang
4. Lucas Bilaver
5. Hina Bhakta
6. Hannah D. Stacey
7. Jann C. Ang
8. Jonathan L. Bramson
9. Ishac Nazy
10. Matthew S. Miller
11. Judah Denburg
12. Andrew P. Costa
13. Dawn M. E. Bowdish
14. other members of the COVID-in-LTC Investigator Group

Reviewed by ScreenIT

Cross-sectional analysis of the humoral response after SARS-CoV-2 vaccination in Sardinian multiple sclerosis patients, a follow-up study

1. Maria Laura Idda
2. Maristella Pitzalis
3. Valeria Lodde
4. Annalisa Loizedda
5. Jessica Frau
6. Monia Lobina
7. Magdalena Zoledziewska
8. Francesca Virdis
9. Giuseppe Delogu
10. Maria Giuseppina Marini
11. Maura Mingoia
12. Marco Masala
13. Lorena Lorefice
14. Marzia Fronza
15. Daniele Carmagnini
16. Elisa Carta
17. Silvy Pilotto
18. Paolo Castiglia
19. Paola Chessa
20. Sergio Uzzau
21. Gabriele Farina
22. Paolo Solla
23. Maristella Steri
24. Marcella Devoto
25. Edoardo Fiorillo
26. Matteo Floris
27. Roberto Ignazio Zarbo
28. Eleonora Cocco
29. Francesco Cucca

Reviewed by ScreenIT

B cells, BAFF and interferons in MIS-C

1. Adam Klocperk
2. Marketa Bloomfield
3. Zuzana Parackova
4. Ludovic Aillot
5. Jiri Fremuth
6. Lumir Sasek
7. Jan David
8. Filip Fencl
9. Aneta Skotnicova
10. Katerina Rejlova
11. Martin Magner
12. Ondrej Hrusak
13. Anna Sediva

Reviewed by ScreenIT

Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands

1. Lotus Leonie van den Hoogen
2. Mardi Boer
3. Abigail Postema
4. Lia de Rond
5. Mary-lène de Zeeuw-Brouwer
6. Inge Pronk
7. Alienke Jentien Wijmenga-Monsuur
8. Elske Bijvank
9. Caitlyn Kruiper
10. Lisa Beckers
11. Marjan Bogaard-van Maurik
12. Ilse Zutt
13. Jeffrey van Vliet
14. Rianne van Bergen
15. Marjan Kuijer
16. Gaby Smits
17. W. M. Monique Verschuren
18. H. Susan J. Picavet
19. Fiona Regina Maria van der Klis
20. Gerco den Hartog
21. Robert Samuel van Binnendijk
22. Anne-Marie Buisman

Reviewed by ScreenIT

Machine-Learning-Assisted Analysis of TCR Profiling Data Unveils Cross-Reactivity between SARS-CoV-2 and a Wide Spectrum of Pathogens and Other Diseases

1. Georgios K. Georgakilas
2. Achilleas P. Galanopoulos
3. Zafeiris Tsinaris
4. Maria Kyritsi
5. Varvara A. Mouchtouri
6. Matthaios Speletas
7. Christos Hadjichristodoulou

Reviewed by ScreenIT

Effectiveness of COVID-19 Vaccines against SARS-CoV-2 Omicron Variant (B.1.1.529): A Systematic Review with Meta-Analysis and Meta-Regression

1. Nando Reza Pratama
2. Ifan Ali Wafa
3. David Setyo Budi
4. Henry Sutanto
5. Tri Pudy Asmarawati
6. Gema Barlian Effendi
7. Citrawati Dyah Kencono Wungu

Reviewed by ScreenIT

Evidence for Aerosol Transfer of SARS-CoV2-specific Humoral Immunity

1. Ross M. Kedl
2. Elena Hsieh
3. Thomas E. Morrison
4. Gabriela Samayoa-Reyes
5. Siobhan Flaherty
6. Conner L. Jackson
7. Rosemary Rochford

Reviewed by ScreenIT

Effects of boosted mRNA and adenoviral‐vectored vaccines on immune responses to omicron BA.1 and BA.2 following the heterologous CoronaVac/AZD1222 vaccination

1. Nungruthai Suntronwong
2. Sitthichai Kanokudom
3. Chompoonut Auphimai
4. Suvichada Assawakosri
5. Thanunrat Thongmee
6. Preeyaporn Vichaiwattana
7. Thaneeya Duangchinda
8. Warangkana Chantima
9. Pattarakul Pakchotanon
10. Jira Chansaenroj
11. Jiratchaya Puenpa
12. Pornjarim Nilyanimit
13. Donchida Srimuan
14. Thaksaporn Thatsanatorn
15. Natthinee Sudhinaraset
16. Nasamon Wanlapakorn
17. Juthathip Mongkolsapaya
18. Yong Poovorawan

Reviewed by ScreenIT