Allergy and Immunology

  1. Seroconversion stages COVID19 into distinct pathophysiological states

    1. Matthew D Galbraith
    2. Kohl T Kinning
    3. Kelly D Sullivan
    4. Ryan Baxter
    5. Paula Araya
    6. Kimberly R Jordan
    7. Seth Russell
    8. Keith P Smith
    9. Ross E Granrath
    10. Jessica R Shaw
    11. Monika Dzieciatkowska
    12. Tusharkanti Ghosh
    13. Andrew A Monte
    14. Angelo D'Alessandro
    15. Kirk C Hansen
    16. Tellen D Benett
    17. Elena WY Hsieh
    18. Joaquín M Espinosa

    • Curated by eLife

      Evaluation Summary:

      In this study, the authors use a systems immunology approach to document innate and adaptive immune responses during clincal SARS-CoV-2 infection. This general impact of this work is a better understanding of COVID19 pathobiology and more specifically, the identification of serum antibodies as a novel classification framework to understand COVID-19 disease course and associated changes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    5 evaluationsAppears in 2 listsLatest version Latest activity

  2. Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine

    1. Florian Krammer
    2. Komal Srivastava
    3. the PARIS team
    4. Viviana Simon

    Reviewed by ScreenIT, NCRC

    2 evaluationsAppears in 3 listsLatest version Latest activity

  3. Perinatal granulopoiesis and risk of pediatric asthma

    1. Benjamin A Turturice
    2. Juliana Theorell
    3. Mary Dawn Koenig
    4. Lisa Tussing-Humphreys
    5. Diane R Gold
    6. Augusto A Litonjua
    7. Emily Oken
    8. Sheryl L Rifas-Shiman
    9. David L Perkins
    10. Patricia W Finn

    • Curated by eLife

      Summary: This is a nice study that is clearly written and makes use of several datasets. It attempts to explain perinatal risk factors and the associated risk of developing pediatric asthma in the mid-childhood and early teenage years. Identified among maternal characteristics that were associated with risks of subsequent asthma development included atopy, BMI, race/ethnicity and demographics, birth characteristics, and mode of delivery. The paper then goes on to demonstrate the differences in immune response during the different time frames of pregnancy. Most notably, a gene signature associated with increased myelopoiesis in utero is associated with increased risk of pediatric asthma. Furthermore they show that cord blood serum PGLYRP -1 is associated with reduced risk of pediatric asthma and increased FEV1/FVC. Interestingly sIL6ra which is derived from neutrophils but not associated with neutrophil granules did not show any association with pulmonary outcomes. This suggests that it is the neutrophil granules rather than the neutrophils per se that are the problem association.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Distinct immune signatures discriminate SARS-CoV-2 vaccine combinations

    1. Nicolás Gonzalo Núñez
    2. Jonas Schmid
    3. Laura Power
    4. Chiara Alberti
    5. Sinduya Krishnarajah
    6. Stefanie Kreutmair
    7. Susanne Unger
    8. Sebastián Blanco
    9. Brenda Konigheim
    10. Constanza Marín
    11. Luisina Onofrio
    12. Jenny Christine Kienzler
    13. Sara da Costa Pereira
    14. Florian Ingelfinger
    15. InmunoCovidCba
    16. InViV working group
    17. Marina E. Pasinovich
    18. Juan M Castelli
    19. Carla Vizzotti
    20. Maximilian Schaefer
    21. Juan Villar-Vesga
    22. Carla Helena Merten
    23. Aakriti Sethi
    24. Tobias Wertheimer
    25. Mirjam Lutz
    26. Danusia Vanoaica
    27. Claudia Sotomayor
    28. Adriana Gruppi
    29. Christian Münz
    30. Diego Cardozo
    31. Gabriela Barbás
    32. Laura Lopez
    33. Paula Carreño
    34. Gonzalo Castro
    35. Elias Raboy
    36. Sandra Gallego
    37. Gabriel Morón
    38. Laura Cervi
    39. Eva V Acosta Rodriguez
    40. Belkys A Maletto
    41. Mariana Maccioni
    42. Burkhard Becher

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  5. Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial

    1. David A. Jolliffe
    2. Giulia Vivaldi
    3. Emma S. Chambers
    4. Weigang Cai
    5. Wenhao Li
    6. Sian E. Faustini
    7. Joseph M. Gibbons
    8. Corinna Pade
    9. Anna K. Coussens
    10. Alex G. Richter
    11. Áine McKnight
    12. Adrian R. Martineau

    Reviewed by Rapid Reviews Infectious Diseases

    4 evaluationsAppears in 1 listLatest version Latest activity
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