The impact of shifting demographics, variants of concern and vaccination on outcomes during the first 3 COVID-19 waves in Alberta and Ontario: a retrospective cohort study
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Abstract
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SciScore for 10.1101/2021.08.27.21261857: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics: Ethical approval for this study was granted by the University of Alberta Health Ethics Research Board (Pro00101096), with waiver of individual patient signed informed consent for Alberta data as we analyzed de-identified healthcare administrative data within the secure environment of the Alberta Strategy for Patient Oriented Research Support Unit.
Consent: Ethics: Ethical approval for this study was granted by the University of Alberta Health Ethics Research Board (Pro00101096), with waiver of individual patient signed informed consent for Alberta data as we analyzed de-identified healthcare administrative data within the secure environment of the Alberta Strategy for Patient …SciScore for 10.1101/2021.08.27.21261857: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics: Ethical approval for this study was granted by the University of Alberta Health Ethics Research Board (Pro00101096), with waiver of individual patient signed informed consent for Alberta data as we analyzed de-identified healthcare administrative data within the secure environment of the Alberta Strategy for Patient Oriented Research Support Unit.
Consent: Ethics: Ethical approval for this study was granted by the University of Alberta Health Ethics Research Board (Pro00101096), with waiver of individual patient signed informed consent for Alberta data as we analyzed de-identified healthcare administrative data within the secure environment of the Alberta Strategy for Patient Oriented Research Support Unit.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A limitation of our analysis is that it is largely based on Alpha variant infections and additional research is needed to determine whether other VOC exert similar risk.[3,6,7] In particular, given emerging evidence that the Delta variant replicates faster and Delta-infected individuals have much higher viral loads (over 1,200 fold in a recent preprint)[8], there is an urgent need to define the phenotype of Delta variant disease. As with other studies comparing VOC and non-VOC infections, our sampling frame may result in overestimates of absolute risks since minimally symptomatic patients are less likely to be tested. However, we examined all positive community cases, which is less biased than studying only hospitalized cases (which prior studies have done) and sample positivity rates were similar in all 3 waves (approximately 5%). Unfortunately, the duration of the pre-symptomatic stage (and the frequency of asymptomatic cases) with different SARS-CoV-2 clades are not yet described and cannot be assessed using our dataset. Finally, although we do not have data on vaccination status in our dataset, initial vaccine roll-out in Canada in January and February 2021 focused on long term care residents, the very elderly, indigenous adults, and front line health care workers only and it was not until mid-March that vaccination eligibility criteria expanded to include other groups in both provinces.[9,10] While genomic monitoring for the evolution of SARS-CoV-2 VOCs is crucial,[11] w...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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