Prevalence and Clinical Correlates of Polycystic Ovarian Syndrome in Patients with Interstitial Cystitis/Bladder Pain Syndrome
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Introduction and Hypothesis
Polycystic Ovarian Syndrome (PCOS) occurs in 10% of women and hyperandrogenism is correlated with a symptom profile of pain and urinary dysfunction which overlaps with IC/BPS. In this study, we perform a cursory evaluation of the IC/BPS patient population to determine prevalence of PCOS and compare clinical features between patients with and without PCOS. We hypothesize that prevalence of PCOS in IC/BPS will be comparable to the general population and patients will have a unique symptom profile.
Methods
We performed a retrospective chart review of female patients (n=470) in our IC/BPS registry (IRB00018552) who underwent therapeutic hydrodistension and compared patients with PCOS diagnosis (n=15) to all other female patients (n=455) as well as an age, race, and parity matched control group (n=16). Univariate analysis was used to compare demographics and clinical features (Fisher exact test for categorical value comparison and Mann-Whitney U test for continuous variables). Variables significant on univariate analysis were then assessed with multiple logistic regression.
Results
We found that 3.19% of IC/BPS registry patients had a concurrent PCOS diagnosis. Patients were younger at initial IC/BPS diagnosis and had a higher BMI than non-PCOS patients. Patients with PCOS had similar IC/BPS features, symptom scores, and patient reported co-morbidities and non-urologic conditions to age, race, and parity match controls.
Conclusions
Further evaluation is needed of this IC/BPS subgroup to determine if low PCOS prevalence is due to a protective effect against IC/BPS and/or if hyperandrogenism contributes to the etiopathology of IC/BPS in patients with concurrent PCOS.
Brief Summary
Only 3.19% of IC/BPS patients receiving tertiary level urology care and hydrodistension treatment have concurrent PCOS. These patients are younger and have a higher BMI.
