Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring
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Significance
Continuous, non-invasive monitoring of cardiovascular physiology provides critical information for clinical decision-making and patient care. Emerging optical sensors enable non-contact measurement of physiological parameters such as heart rate and respiratory rate, but current methods are limited in their ability to capture spatially resolved physiological waveforms.
Aim
We aimed to extend the capabilities of non-contact cardiovascular monitoring by using an imaging-based approach from which spatially resolved physiological waveforms can be extracted and cardiovascular biomarkers can be derived in vivo .
Approach
We implemented a digital holographic imaging sensor to continuously measure calibrated tissue motion for in vivo assessment of cardiovascular biomarkers in six adult male Sprague-Dawley rats, with validation against electrocardiographic and invasive arterial blood pressure measurements.
Results
Heart rate and pulse arrival time-derived pulse wave velocity calculated from digital holographic imaging demonstrate strong agreement with reference-derived metrics (concordance correlation coefficient ≥ 0.98). Heart rate variability shows moderate agreement with reference-derived metrics (concordance correlation coefficient ≥ 0.59).
Conclusions
Digital holographic imaging is a promising modality for non-contact cardiovascular monitoring, allowing for continuous measurement of tissue motion that enables assessment of key cardiovascular biomarkers.
