Lopinavir-ritonavir alone or combined with arbidol in the treatment of 73 hospitalized patients with COVID-19: A pilot retrospective study
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2020.04.25.20079079: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Study Design and Participants: The protocol was approved by the Ethics Committee of Lishui Hospital of Zhejiang University (Ethical Review of Clinical Research-2020-5) and was registered in Chinese Clinical Trail Registry (ChiCTR2000030391). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS (Statistical Package for Results the Social Sciences) version 16.0 software (SPSS Inc). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: Thank you for sharing your data.
Results from Limitat…SciScore for 10.1101/2020.04.25.20079079: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Study Design and Participants: The protocol was approved by the Ethics Committee of Lishui Hospital of Zhejiang University (Ethical Review of Clinical Research-2020-5) and was registered in Chinese Clinical Trail Registry (ChiCTR2000030391). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS (Statistical Package for Results the Social Sciences) version 16.0 software (SPSS Inc). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our trial has several limitations. First, this study was a retrospective analysis with no randomized, future prospective study can overcome this defect. Second, there were only 73 COVID-19 cases in this study. According to the study data of lopinavir-ritonavir in the treatment of severe COVID-19 cases[11], we concluded that the sample size need 300 subjects to evaluate the efficacy of lopinavir-ritonavir combined with abidor was better or worse than that of the single drug treatment of lopinavir-ritonavir. Third, the age and gender of two groups were not balanced because of the small sample. However, there was no significant difference between groups after stratification of gender and age. In the future, increasing the number of research samples can improve the test efficiency and enhance the credibility of research results. Finally, the results of this study suggested that the overall treatment effect of COVID-19 was well. It was difficult to judge the antiviral effect using cure rate and virus turning negative rate as the primary endpoints. Therefore, it may be more feasible in clinical practice to find a more suitable COVID-19 population or primary endpoints for evaluating the therapeutic effect of antiviral drugs, such as evaluating whether it can reduce mortality in severely ill population. In conclusion, we found that lopinavir–ritonavir alone or combined with arbidol treatment did not significantly increase cure rate, reduce hospitalization time, raise virus negative r...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
SciScore for 10.1101/2020.04.25.20079079: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Study Design and Participants The protocol was approved by the Ethics Committee of Lishui Hospital of Zhejiang University ( Ethical Review of Clinical Research-2020-5 ) and was registered in Chinese Clinical Trail Registry ( ChiCTR2000030391) . Randomization First, this study was a retrospective analysis with no randomized, future prospective study can overcome this defect. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS ( Statistical Package for Results the Social Sciences ) version 16.0 software ( … SciScore for 10.1101/2020.04.25.20079079: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Study Design and Participants The protocol was approved by the Ethics Committee of Lishui Hospital of Zhejiang University ( Ethical Review of Clinical Research-2020-5 ) and was registered in Chinese Clinical Trail Registry ( ChiCTR2000030391) . Randomization First, this study was a retrospective analysis with no randomized, future prospective study can overcome this defect. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS ( Statistical Package for Results the Social Sciences ) version 16.0 software ( SPSS Inc) . SPSSsuggested: (SPSS, SCR_002865)COVID-19 is an acute or chronic pneumonia caused by SARS-COV-2 infection[15]. SARS-COV-2suggested: (SARS-CoV-2-Sequences, SCR_018319)Results from OddPub: Thank you for sharing your data.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.
-
