8-(Dichloromethylene)-3,4,7,8-tetrahydro-6 H -imidazo[5,1- c ][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation

  1. Oleh V Shablykin
  2. Yurii Eu Kornii
  3. Kateryna R Bondarenko
  4. Svitlana V Shishkina
  5. Andrii V Kozytskyi
  6. Olga V Shablykina
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Abstract

Through cyclization of 4-(dichloromethylene)-5-(aminosulfonylimino)imidazolidin-2-ones by formaldehyde action series of 8-(dichloromethylene)-3,4,7,8-tetrahydro-6 H -imidazo[5,1- c ][1,2,4,6]thiatriazin-6-one 2,2-dioxides were synthesized. Their structure parameters were discovered by NMR experiments and X-Ray analysis. The separate products (with allyl, carbethoxymethyl, 2- N -Boc-aminoethyl, 2-( N -Boc- N -isopropoxymethylamino)ethyl substituents in position 3) demonstrated high antiproliferative activity

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  1. Version published to 10.3762/bxiv.2026.7.v1