One-pot synthesis of 1,8-dioxo-decahydroacridines and 1,8-dioxo- octahydroxanthene derivatives using novel biopolymer Xanthan Perchloric Acid (XPA) catalyst

The synthesis of xanthene-1,8-dione and acridine-1,8-dione derivatives is of significant interest due to their potential applications in various fields, including pharmaceuticals and materials science. A simple, ecofriendly, and efficient green method has been developed for one-pot multicomponent synthesis of antiviral and antibacterial agent 1,8-dioxo- octahydroxanthenes. This is a reaction between 1 mole of aldehyde and 2 moles of dimedone in the presence of a solvent system, water- alcohol, under reflux conditions. Microwave-assisted acridine-1,8-diones are synthesized using three components: aryl aldehydes, dimedone, and ammonium acetate in ethanol solvent with excellent yields. The recyclable catalyst Xanthan Perchloric Acid (XPA) yields a high atom efficiency within a short time duration. The prepared acridine and xanthene derivatives are characterized by spectroscopic techniques. These innovative approaches reflect the ongoing efforts to optimize the synthesis of acridine and xanthene derivatives, making the process more efficient, cost-effective, and environmentally benign with the help of reusable catalyst.