Green synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/­triazolobenzodiazepine derivatives via isocyanide-based multicomponent reactions

An efficient and facile synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/ triazolobenzodiazepine derivatives were developed through the isocyanide-based multicomponent reaction of isocyanides, gem-diactivated olefins and cyclic imines such as dibenzoxazepine, dibenzothiazepine and triazolobenzodiazepine under solvent- and catalyst-free conditions. Purposefully, this approach produced various biological scaffolds using environmentally friendly, mild, and simple conditions. Due to their bioactive moieties, these compounds with exclusive fluorescence properties may attract great attention in biomedical applications, clinical diagnostics, and conjugate materials.