The Role of Procalcitonin in Early Differential Diagnosis of Suspected Children with COVID-19

  1. Denggao Peng

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Abstract

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  1. Version published to 10.26717/bjstr.2021.34.005560
  2. ScreenIT

    SciScore for 10.1101/2020.04.07.20057315: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.
    Cell Line AuthenticationContamination: Based on laboratory pathogen identification results including 2019 novel coronavirus, influenza A, B (INF A, INF B), respiratory syncytial virus (RSV), mycoplasma pneumoniae (MP), and bacteria, all cases were divided into the COVID-19 confirmed group and the non-COVID-19 group.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    SPSS Inc, Chicago, IL).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    However, this method had its limitations, such as false positive or false negative results, time consuming, false sampling, inconsistence of sample collections and preparations. Most importantly, the inaccuracy of RT-PCR method caused problems in timely triage, isolating the source of infection, the following reasonable treatment, early removal of isolation, and improvement of psychological stress in children. In addition, CT changes in novel coronaviral pneumonia are nonspecific and difficult to differentiate from other viral infections [6,11]. Therefore, it is necessary to start from other clinical features and laboratory data, independent of nucleic acid detection and chest CT, to provide a basis for early differential diagnosis. As a viral infection, it is obvious that children are especially susceptible to COVID-19. Most of the infected children we observed are asymptomatic or mildly febrile and or symptoms of ARI [3,15]. However, the changes of chest CT are very typical of viral pneumonia [11], which is consistent with the results of other relevant reports. Also, from the COVID-19 cases with coinfection, they all had fever and symptoms of ARI, chest CT findings of viral pneumonia were also typical. Therefore, COVID-19 with other viral coinfections may be more common in children [6]. Pediatric patients should be alert to the possibility of coinfection if severe symptoms appear. Compared with other non-bacterial pathogens, COVID-19 has more family cluster infections, whic...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  3. Version published to 10.1101/2020.04.07.20057315v3 on medRxiv
  4. Version published to 10.1101/2020.04.07.20057315v2 on medRxiv
  5. Version published to 10.1101/2020.04.07.20057315v1 on medRxiv