Efficacy and Safety of Andrographis Paniculata Extract in Patients with Mild COVID-19: A Randomized Controlled Trial
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SciScore for 10.1101/2021.07.08.21259912: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This trial was approved by the Ethics Committee for Research in Human Subjects in the Fields of Thai Traditional and Alternative Medicine (No.12-2563). Sex as a biological variable Patients were excluded if they (1) had any underlying medical conditions that increase the risk of severe COVID-19; (2) had any conditions for which using A. paniculata should be avoided, i.e., history of allergy to A. paniculata, taking antihypertensive or anticoagulant drugs, or being pregnant or lactating; or (3) were receiving any antiviral drug. Randomization The patients were randomized 1:1, with six-block randomization using a computer program, to receive oral APE or placebo within 24 hours after … SciScore for 10.1101/2021.07.08.21259912: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This trial was approved by the Ethics Committee for Research in Human Subjects in the Fields of Thai Traditional and Alternative Medicine (No.12-2563). Sex as a biological variable Patients were excluded if they (1) had any underlying medical conditions that increase the risk of severe COVID-19; (2) had any conditions for which using A. paniculata should be avoided, i.e., history of allergy to A. paniculata, taking antihypertensive or anticoagulant drugs, or being pregnant or lactating; or (3) were receiving any antiviral drug. Randomization The patients were randomized 1:1, with six-block randomization using a computer program, to receive oral APE or placebo within 24 hours after admission, with similar standard supportive care in both groups following the national clinical practice guideline. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All analyses were performed by STATA version 16.0, and p-value <0.05 was considered as statistically significant. STATAsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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