HLA and Red Blood Cell Antigen Genotyping in SARS-CoV-2 Convalescent Plasma Donors

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Abstract

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  1. SciScore for 10.1101/2021.03.17.21253821: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: All donors gave consent to participate in this research project, which was approved by the Héma-Québec Research Ethics Committee.
    IRB: All donors gave consent to participate in this research project, which was approved by the Héma-Québec Research Ethics Committee.
    RandomizationSamples: Caucasian convalescent plasmas were randomly chosen from adult participants in the CONCOR-1 study (#NCT04348656), from the Québec cohort having received an official diagnosis of COVID-19 by the Québec Provincial Health Authority after epidemiologic investigation or confirmed by polymerase chain reaction (PCR) tests.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableThe average age of our convalescent plasma donor cohort was 40.4 ± 15.0 years and included 68% males.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04348656Active, not recruitingCONvalescent Plasma for Hospitalized Adults With COVID-19 Re…


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.