A Simplified Computational Framework for Modeling Exosome-Mediated Local Drug Delivery

Objective Exosome-based nanocarriers have attracted increasing attention as potential vehicles for localized drug delivery due to their biocompatibility and nanoscale transport properties. However, early-stage evaluation of their distribution and release behavior remains experimentally demanding. This study presents a simplified computational framework to explore the theoretical dynamics of exosome-mediated local drug delivery. Results A minimal compartmental model was developed to simulate exosome distribution, drug release, local accumulation, clearance, and a generic concentration–effect relationship. Simulations illustrate parameter-dependent trends in local drug concentration and systemic exposure. While the framework does not aim to provide quantitative physiological predictions, it offers a transparent and reproducible structure for hypothesis generation and early-stage nanocarrier design exploration.