Trends and Disparities in cerebrovascular disease mortality among patients with bronchus and lung cancer in the United States, 1999-2020: A Population-Based Retrospective Study

Background Bronchus and lung cancer are highly prevalent and fatal malignant tumors worldwide. Cerebrovascular disease is a leading cause of years of life lost among bronchus and lung cancer patients. However, previous studies have mostly been single-center and small-sample, lacking population-level mortality trends and population differences analysis. Methods A retrospective study was conducted based on the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database to analyze the cerebrovascular disease-related mortality data of bronchus and lung cancer patients aged ≥ 25 years in the United States from 1999 to 2020. The Joinpoint regression model was used to analyze the trend of age-adjusted mortality rate and subgroup differences. Results Of the 3.5987 million bronchus and lung cancer-related deaths, 10,970 (0.3%) were attributed to cerebrovascular disease. The overall age-adjusted mortality rate decreased from 0.34 to 0.20 (Average Annual Percent Change =-2.44, p < 0.001), and slightly rebounded after 2014. Unspecified stroke as the main subtype, cerebral infarction shows a non-significant upward trend. Men aged 65 and above, non-Hispanic blacks and rural residents have higher age-adjusted mortality rate, with significant interstate differences. Conclusion From 1999 to 2020, the mortality rate of bronchus and lung cancer combined with cerebrovascular disease decreased overall but has stabilized in recent years. There are obvious group differences. Targeted optimization of cardio-cerebrovascular oncology management strategies is needed to mitigate health inequalities.