Ayurvedic Interventions for Lifestyle-Related Metabolic Disorders: A PRISMA-2020–Compliant Systematic Review

Background Lifestyle-related metabolic disorders, including metabolic syndrome, type 2 diabetes mellitus (T2DM), dyslipidemia, obesity, hypertension, and non-alcoholic fatty liver disease (NAFLD), constitute a major global public health challenge. Ayurveda offers a holistic and preventive framework incorporating dietary regulation, lifestyle modification, Panchakarma therapies, and herbal formulations. However, consolidated clinical evidence remains fragmented. Objective To systematically evaluate and synthesize clinical evidence on the efficacy and safety of Ayurvedic interventions in the management of lifestyle-related metabolic disorders. Methods This systematic review was conducted in accordance with the PRISMA-2020 guidelines. Electronic databases including PubMed, Google Scholar, and Ayurveda-specific peer-reviewed journals were searched for randomized controlled trials (RCTs), cohort studies, and systematic reviews evaluating Ayurvedic interventions. Data were extracted and synthesized narratively. Results One hundred studies were assessed for inclusion criteria, out of which 12 were found to be eligible. Evidence suggests that selected Ayurvedic interventions improve glycemic control, lipid profiles, anthropometric measures, blood pressure, and liver function parameters. Considerable heterogeneity in study design and methodological quality was observed. Conclusion Ayurvedic interventions appear to offer beneficial adjunctive strategies for managing lifestyle-related metabolic disorders. High-quality, standardized, multicenter RCTs are required to strengthen clinical applicability.