Electrospun poly(vinyl alcohol)-chitosan nanofibers integrated with mangiferin: fabrication and properties
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Mangiferin, a natural antioxidant with demonstrated therapeutic potential against a range of serious diseases, faces significant limitations in clinical application due to its extremely low water solubility and poor bioavailability. To address these challenges, this study reports the fabrication and characterization of a novel nanofiber drug delivery system that integrates mangiferin into a biocompatible polymer matrix composed of poly (vinyl alcohol) (PVA) and chitosan (CS). Using a three-component solvent system, the electrospun solution achieved a mangiferin content 5 to 10 times higher than its aqueous solubility, resulting in nanofibers containing 6.7 to 12.5% mangiferin by weight. Optimization of electrospinning parameters identified 4% PVA, 3% CS, 0.5% mangiferin, 45% CH 3 COOH, and 15% C 2 H 5 OH as the optimal formulation, with a 150mm needle-collector distance, 0.2 mL/h feed rate, and 28 kV voltage, yielding uniform nanofibers with an average diameter of 332 ± 84 nm. UV-Vis spectra confirmed the stability of mangiferin in solution for at least 40 days at room temperature, while IR spectra indicated strong interactions between mangiferin and the polymer matrix. Increasing mangiferin loading slightly reduced overall crystallinity and increased cell size, influencing the glass transition, melting behavior, thermal decomposition, and mechanical properties of the nanofibers. These findings demonstrate that PVA–CS–mangiferin nanofibers are a promising platform for enhancing the solubility, stability, and controlled release of mangiferin, supporting their potential application in advanced drug delivery systems.
